FRE8_YEAST - dbPTM
FRE8_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID FRE8_YEAST
UniProt AC Q12209
Protein Name Probable ferric reductase transmembrane component 8
Gene Name FRE8
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 686
Subcellular Localization Membrane
Multi-pass membrane protein.
Protein Description Required for the uptake of Fe(3+) ions. May participate in the transport of electrons from cytoplasm to an extracellular substrate (Fe(3+) ion) via FAD and heme intermediates (By similarity). Involved in iron homeostasis..
Protein Sequence MNLKSIVSWFKEHLPSFDVDVDKHFRTLRVRKYSQICLLISFIIICVIIPLMNYLLLTDKFFKICHHLKHHVFNRRSWVHKTHMYHKQSLQLCLICFVFTSFFVIQGANGDLLEITKRMGRISVALMPPLLFLTLRPSPLPHTLYLALLPLHKWISRIVVLESILHTWFYLYYMYINDTLYVKMRKLPNIYGVIALGLFLLIAITSVRYARRWSYRVFYYVHYVSTWLILVFLHYHARPGISYYTTLNVLILTGQIVYRLHITNVTRVTIVPISSSLSLLEFPLTDLPKKPILPGGHLRINIYHRNFLRRFFSHLIPFQHPFTIASIPSDNLVRLIIRNGHFPLRTNEKYYITGAFEPELSFISKPTVPFNITTKSSKNPFRNNSSALINSPLNFLIKAQRVFMCVGGSGISFGLPLLRILNFNGVNVRLLWVSRDYKDLEVLNHFKNNFEGMEIYISGTEGNEQDIEIDYIDYHDCAADINDEVRSISSSGRVSELGDNSMLSDGNPQPTEPNENTALLSKKSTLRNHHPPKTSDIPDINADDEIDFTYAFSRSKSRKNTAQGTLTTHSSFNGSSVFRQPKIIEPPAQDPCLEAAPKKIRIPAGVKVFFGRPTLGDKDYEWCLQTECDAETDSIQCCRWANQGRDHAEYLSQVWVLAAGPRGLIESTKRWATDGGLHFHGESFAL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
371N-linked_GlycosylationSKPTVPFNITTKSSK
CCCCCCCCCCCCCCC		25.32-
383N-linked_GlycosylationSSKNPFRNNSSALIN
CCCCCCCCCCCHHHC		53.79-
384N-linked_GlycosylationSKNPFRNNSSALINS
CCCCCCCCCCHHHCC		32.84-
385PhosphorylationKNPFRNNSSALINSP
CCCCCCCCCHHHCCH		22.1224961812
386PhosphorylationNPFRNNSSALINSPL
CCCCCCCCHHHCCHH		29.2624961812
487PhosphorylationDINDEVRSISSSGRV
CCCHHHHHHHCCCCC		31.8128889911
561PhosphorylationRSKSRKNTAQGTLTT
CCCCCCCCCCEEEEE		24.3219823750
565PhosphorylationRKNTAQGTLTTHSSF
CCCCCCEEEEECCCC		14.6219823750
567PhosphorylationNTAQGTLTTHSSFNG
CCCCEEEEECCCCCC		23.4619823750
568PhosphorylationTAQGTLTTHSSFNGS
CCCEEEEECCCCCCC		23.9121440633
570PhosphorylationQGTLTTHSSFNGSSV
CEEEEECCCCCCCCC		34.2424961812
571PhosphorylationGTLTTHSSFNGSSVF
EEEEECCCCCCCCCC		18.3521440633
575PhosphorylationTHSSFNGSSVFRQPK
ECCCCCCCCCCCCCC		25.1624961812
576PhosphorylationHSSFNGSSVFRQPKI
CCCCCCCCCCCCCCC		27.0319823750
582UbiquitinationSSVFRQPKIIEPPAQ
CCCCCCCCCCCCCCC		48.2323749301
598UbiquitinationPCLEAAPKKIRIPAG
CHHHCCCCCCEECCC		56.9823749301
634PhosphorylationECDAETDSIQCCRWA
CCCCCCCCHHHHHHH		23.2125704821
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of FRE8_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of FRE8_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of FRE8_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
RAD1_YEASTRAD1genetic
27708008
UBC4_YEASTUBC4genetic
27708008
SGF29_YEASTSGF29genetic
27708008
THRC_YEASTTHR4genetic
27708008
PEX19_YEASTPEX19genetic
27708008
RLA4_YEASTRPP2Bgenetic
27708008
UBP3_YEASTUBP3genetic
27708008
ODPA_YEASTPDA1genetic
27708008
PEX14_YEASTPEX14genetic
27708008
VPS53_YEASTVPS53genetic
27708008
YKC3_YEASTYKL023Wgenetic
27708008
SHE2_YEASTSHE2genetic
27708008
SPO14_YEASTSPO14genetic
27708008
PAM17_YEASTPAM17genetic
27708008
BRE5_YEASTBRE5genetic
27708008
RMI1_YEASTRMI1genetic
27708008
SUR1_YEASTSUR1genetic
27708008
ELP3_YEASTELP3genetic
27708008
HSP7F_YEASTSSE1genetic
27708008
AIM44_YEASTAIM44genetic
27708008
MED1_YEASTMED1genetic
27708008
YP089_YEASTYPR089Wgenetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of FRE8_YEAST

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Related Literatures of Post-Translational Modification

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