ALDH4_YEAST - dbPTM
ALDH4_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ALDH4_YEAST
UniProt AC P46367
Protein Name Potassium-activated aldehyde dehydrogenase, mitochondrial
Gene Name ALD4
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 519
Subcellular Localization Mitochondrion matrix .
Protein Description Potassium-activated aldehyde dehydrogenase involved in acetate formation during anaerobic growth on glucose..
Protein Sequence MFSRSTLCLKTSASSIGRLQLRYFSHLPMTVPIKLPNGLEYEQPTGLFINNKFVPSKQNKTFEVINPSTEEEICHIYEGREDDVEEAVQAADRAFSNGSWNGIDPIDRGKALYRLAELIEQDKDVIASIETLDNGKAISSSRGDVDLVINYLKSSAGFADKIDGRMIDTGRTHFSYTKRQPLGVCGQIIPWNFPLLMWAWKIAPALVTGNTVVLKTAESTPLSALYVSKYIPQAGIPPGVINIVSGFGKIVGEAITNHPKIKKVAFTGSTATGRHIYQSAAAGLKKVTLELGGKSPNIVFADAELKKAVQNIILGIYYNSGEVCCAGSRVYVEESIYDKFIEEFKAASESIKVGDPFDESTFQGAQTSQMQLNKILKYVDIGKNEGATLITGGERLGSKGYFIKPTVFGDVKEDMRIVKEEIFGPVVTVTKFKSADEVINMANDSEYGLAAGIHTSNINTALKVADRVNAGTVWINTYNDFHHAVPFGGFNASGLGREMSVDALQNYLQVKAVRAKLDE
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
52AcetylationTGLFINNKFVPSKQN
CEEEECCEECCCCCC		43.1624489116
96PhosphorylationQAADRAFSNGSWNGI
HHHHHHHHCCCCCCC		39.0222369663
99PhosphorylationDRAFSNGSWNGIDPI
HHHHHCCCCCCCCCC		22.9422369663
154PhosphorylationLVINYLKSSAGFADK
HHHHHHHHCCCCCCE		23.8728889911
1612-HydroxyisobutyrylationSSAGFADKIDGRMID
HCCCCCCEECCEEEE		38.99-
208PhosphorylationKIAPALVTGNTVVLK
HHHHHHHCCCEEEEE		26.0919823750
211PhosphorylationPALVTGNTVVLKTAE
HHHHCCCEEEEEECC		17.2119823750
216PhosphorylationGNTVVLKTAESTPLS
CCEEEEEECCCCCCH		31.3428889911
260AcetylationEAITNHPKIKKVAFT
HHHHCCCCEEEEEEE		60.6524489116
263AcetylationTNHPKIKKVAFTGST
HCCCCEEEEEEECCC		42.1222865919
267PhosphorylationKIKKVAFTGSTATGR
CEEEEEEECCCCCCH		22.0822369663
269PhosphorylationKKVAFTGSTATGRHI
EEEEEECCCCCCHHH		16.2922369663
270PhosphorylationKVAFTGSTATGRHIY
EEEEECCCCCCHHHH		29.5922369663
272PhosphorylationAFTGSTATGRHIYQS
EEECCCCCCHHHHHH		34.5322369663
2862-HydroxyisobutyrylationSAAAGLKKVTLELGG
HHHCCCCEEEEECCC		45.56-
3062-HydroxyisobutyrylationVFADAELKKAVQNII
EEECHHHHHHHHHHH		30.14-
306AcetylationVFADAELKKAVQNII
EEECHHHHHHHHHHH		30.1424489116
345AcetylationDKFIEEFKAASESIK
HHHHHHHHHHHCCCC		46.4522865919
367PhosphorylationSTFQGAQTSQMQLNK
HHCCCCCCHHHHHHH		22.0128889911
374AcetylationTSQMQLNKILKYVDI
CHHHHHHHHHHHHCC		58.9924489116
377AcetylationMQLNKILKYVDIGKN
HHHHHHHHHHCCCCC		46.8624489116
3772-HydroxyisobutyrylationMQLNKILKYVDIGKN
HHHHHHHHHHCCCCC		46.86-
383AcetylationLKYVDIGKNEGATLI
HHHHCCCCCCCCEEE		52.7624489116
398PhosphorylationTGGERLGSKGYFIKP
ECCCCCCCCCEEECC		27.7421440633
399AcetylationGGERLGSKGYFIKPT
CCCCCCCCCEEECCE		56.6924489116
404AcetylationGSKGYFIKPTVFGDV
CCCCEEECCEEECCH		25.4124489116
412AcetylationPTVFGDVKEDMRIVK
CEEECCHHHHHHHHH		53.3824489116
419AcetylationKEDMRIVKEEIFGPV
HHHHHHHHHHHHCCE		47.4624489116
431AcetylationGPVVTVTKFKSADEV
CCEEEEEECCCHHHH		46.5924489116
500PhosphorylationSGLGREMSVDALQNY
CCCCCCCCHHHHHHH		16.4628889911
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ALDH4_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ALDH4_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ALDH4_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
ALDH6_YEASTALD6genetic
10919763
IMB2_YEASTKAP104physical
16554755
ODPA_YEASTPDA1genetic
20093466
IMP2_YEASTIMP2genetic
20093466
ATP14_YEASTATP14genetic
21623372
COX7_YEASTCOX7genetic
21623372
QCR9_YEASTQCR9genetic
21623372
TPS2_YEASTTPS2genetic
21623372
ALDH4_YEASTALD4physical
22940862
VMA21_YEASTVMA21genetic
27708008
YJ24_YEASTKCH1genetic
27708008
GPR1_YEASTGPR1genetic
27708008
INO2_YEASTINO2genetic
27708008
GOSR1_YEASTGOS1genetic
27708008
IMP2_YEASTIMP2genetic
27708008
MUB1_YEASTMUB1genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ALDH4_YEAST

loading...

Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Profiling phosphoproteins of yeast mitochondria reveals a role ofphosphorylation in assembly of the ATP synthase.";
Reinders J., Wagner K., Zahedi R.P., Stojanovski D., Eyrich B.,van der Laan M., Rehling P., Sickmann A., Pfanner N., Meisinger C.;
Mol. Cell. Proteomics 6:1896-1906(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-216 AND SER-500, ANDMASS SPECTROMETRY.

TOP
© 2024 Institute of Bioinformatics and Systems Biology, NYCU | Designed by : BiOmics Laboratory