| UniProt ID | LSG1_YEAST | |
|---|---|---|
| UniProt AC | P53145 | |
| Protein Name | Large subunit GTPase 1 | |
| Gene Name | LSG1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 640 | |
| Subcellular Localization | Cytoplasm . | |
| Protein Description | GTPase required for the nuclear export of the 60S ribosomal subunit. Acts by mediating the release of NMD3 from the 60S ribosomal subunit after export into the cytoplasm.. | |
| Protein Sequence | MPPKEAPKKWKAPKGPKPTHRKNKNKLELGRAIKYARQKENAIEYLPDGEMRFTTDKHEANWVKLRSVTQESALDEFLSTAALADKDFTADRHSNVKIIRMDSGNDSATSQGFSMTNEQRGNLNAKQRALAKDLIVPRRPEWNEGMSKFQLDRQEKEAFLEWRRKLAHLQESNEDLLLTPFERNIEVWKQLWRVVERSDLVVQIVDARNPLLFRSVDLERYVKESDDRKANLLLVNKADLLTKKQRIAWAKYFISKNISFTFYSALRANQLLEKQKEMGEDYREQDFEEADKEGFDADEKVMEKVKILSIDQLEELFLSKAPNEPLLPPLPGQPPLINIGLVGYPNVGKSSTINSLVGAKKVSVSSTPGKTKHFQTIKLSDSVMLCDCPGLVFPNFAYNKGELVCNGVLPIDQLRDYIGPAGLVAERIPKYYIEAIYGIHIQTKSRDEGGNGDIPTAQELLVAYARARGYMTQGYGSADEPRASRYILKDYVNGKLLYVNPPPHLEDDTPYTREECEEFNKDLYVFDRLPDTRKEQVQNAAKAKGIDIVDLARDLNQLTFSAHTGGDTQKEAKSVTHGGKQAALYNAAEDLDRDFFKMNNVEGRLSTPFHKVQNSSAGKRHNKKNKSKNAKSKVFSIENN | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 64 | Acetylation | KHEANWVKLRSVTQE HHHCCCEECCCCCHH | 29.78 | 24489116 | |
| 67 | Phosphorylation | ANWVKLRSVTQESAL CCCEECCCCCHHHHH | 39.70 | 21440633 | |
| 69 | Phosphorylation | WVKLRSVTQESALDE CEECCCCCHHHHHHH | 28.06 | 21440633 | |
| 72 | Phosphorylation | LRSVTQESALDEFLS CCCCCHHHHHHHHHH | 25.06 | 21551504 | |
| 89 | Phosphorylation | ALADKDFTADRHSNV HHCCCCCCCCCCCCC | 37.47 | 19779198 | |
| 103 | Phosphorylation | VKIIRMDSGNDSATS CEEEEECCCCCCCHH | 30.10 | 21551504 | |
| 107 | Phosphorylation | RMDSGNDSATSQGFS EECCCCCCCHHCCCC | 37.13 | 21440633 | |
| 109 | Phosphorylation | DSGNDSATSQGFSMT CCCCCCCHHCCCCCC | 26.07 | 23749301 | |
| 110 | Phosphorylation | SGNDSATSQGFSMTN CCCCCCHHCCCCCCH | 28.20 | 29136822 | |
| 114 | Phosphorylation | SATSQGFSMTNEQRG CCHHCCCCCCHHHCC | 31.36 | 29136822 | |
| 116 | Phosphorylation | TSQGFSMTNEQRGNL HHCCCCCCHHHCCCC | 34.11 | 29136822 | |
| 132 | Acetylation | AKQRALAKDLIVPRR HHHHHHHHHCCCCCC | 54.65 | 24489116 | |
| 148 | Acetylation | EWNEGMSKFQLDRQE HHCCCCCHHCCCHHH | 28.39 | 24489116 | |
| 172 | Phosphorylation | KLAHLQESNEDLLLT HHHHHHHCCCCCCCC | 32.34 | 30377154 | |
| 251 | Acetylation | KQRIAWAKYFISKNI HHHHHHHHHHHHCCC | 29.96 | 24489116 | |
| 363 | Phosphorylation | LVGAKKVSVSSTPGK HCCCEEEEECCCCCC | 25.76 | 27738172 | |
| 367 | Phosphorylation | KKVSVSSTPGKTKHF EEEEECCCCCCCCCC | 28.67 | 23749301 | |
| 484 | Phosphorylation | SADEPRASRYILKDY CCCCCHHHHHHHHHH | 27.22 | 19779198 | |
| 489 | Acetylation | RASRYILKDYVNGKL HHHHHHHHHHCCCEE | 37.14 | 24489116 | |
| 489 | Succinylation | RASRYILKDYVNGKL HHHHHHHHHHCCCEE | 37.14 | 23954790 | |
| 544 | Acetylation | VQNAAKAKGIDIVDL HHHHHHHCCCCHHHH | 56.55 | 24489116 | |
| 576 | Phosphorylation | QKEAKSVTHGGKQAA HHHHHHCCCHHHHHH | 23.15 | 28889911 | |
| 606 | Phosphorylation | NNVEGRLSTPFHKVQ CCCCCCCCCCHHHHC | 32.45 | 21440633 | |
| 607 | Phosphorylation | NVEGRLSTPFHKVQN CCCCCCCCCHHHHCC | 34.27 | 29136822 | |
| 632 | Phosphorylation | NKSKNAKSKVFSIEN CCCCCCHHHCEEEEC | 31.47 | 28889911 | |
| 636 | Phosphorylation | NAKSKVFSIENN--- CCHHHCEEEECC--- | 31.79 | 21440633 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of LSG1_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of LSG1_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of LSG1_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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