FES1_YEAST - dbPTM
FES1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID FES1_YEAST
UniProt AC P38260
Protein Name Hsp70 nucleotide exchange factor FES1
Gene Name FES1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 290
Subcellular Localization Cytoplasm .
Protein Description Involved in protein translation, propagation of [PSI+] prions, and polyamine tolerance. Functions as a nucleotide exchange factor (NEF), which accelerates the release of ADP, for the cytosolic Hsp70 chaperone SSA1 and the ribosome-associated Hsp70 chaperone SSB1. Required for fully efficient Hsp70-mediated folding of proteins..
Protein Sequence MEKLLQWSIANSQGDKEAMARAGQPDPKLLQQLFGGGGPDDPTLMKESMAVIMNPEVDLETKLVAFDNFEMLIENLDNANNIENLKLWEPLLDVLVQTKDEELRAAALSIIGTAVQNNLDSQNNFMKYDNGLRSLIEIASDKTKPLDVRTKAFYALSNLIRNHKDISEKFFKLNGLDCIAPVLSDNTAKPKLKMRAIALLTAYLSSVKIDENIISVLRKDGVIESTIECLSDESNLNIIDRVLSFLSHLISSGIKFNEQELHKLNEGYKHIEPLKDRLNEDDYLAVKYVL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
3Ubiquitination-----MEKLLQWSIA
-----CHHHHHHHHH		53.8824961812
12PhosphorylationLQWSIANSQGDKEAM
HHHHHHCCCCCHHHH		26.9025752575
16AcetylationIANSQGDKEAMARAG
HHCCCCCHHHHHHCC		54.9524489116
16UbiquitinationIANSQGDKEAMARAG
HHCCCCCHHHHHHCC		54.9523749301
28UbiquitinationRAGQPDPKLLQQLFG
HCCCCCHHHHHHHHC		70.0323749301
45SulfoxidationGPDDPTLMKESMAVI
CCCCCHHHHHHCCHH		5.0831806703
49SulfoxidationPTLMKESMAVIMNPE
CHHHHHHCCHHCCCC		3.4631806703
53SulfoxidationKESMAVIMNPEVDLE
HHHCCHHCCCCCCCC		5.7131806703
142AcetylationLIEIASDKTKPLDVR
HHHHHCCCCCCCCHH		56.8224489116
143PhosphorylationIEIASDKTKPLDVRT
HHHHCCCCCCCCHHH		42.7728889911
151AcetylationKPLDVRTKAFYALSN
CCCCHHHHHHHHHHH		26.4024489116
157PhosphorylationTKAFYALSNLIRNHK
HHHHHHHHHHHHCCC		22.7819779198
169AcetylationNHKDISEKFFKLNGL
CCCCHHHHHHHHCCC		49.6724489116
225PhosphorylationRKDGVIESTIECLSD
HHCCCCHHHHHHCCC		24.4628889911
231PhosphorylationESTIECLSDESNLNI
HHHHHHCCCCCCCHH		51.4928889911
234PhosphorylationIECLSDESNLNIIDR
HHHCCCCCCCHHHHH		52.1628889911
263AcetylationFNEQELHKLNEGYKH
CCHHHHHHHCCCCCC		66.6824489116
269AcetylationHKLNEGYKHIEPLKD
HHHCCCCCCCCCHHH		49.3024489116
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of FES1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of FES1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of FES1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
HSP42_YEASTHSP42physical
11805826
HSP71_YEASTSSA1physical
12052876
HSP71_YEASTSSA1genetic
15082786
LYS2_YEASTLYS2physical
16554755
SSB2_YEASTSSB2physical
17132105
SSB1_YEASTSSB1physical
17132105
CND3_YEASTYCG1physical
18467557
HSP71_YEASTSSA1physical
18719252
HSP71_YEASTSSA1physical
18706386
HSP71_YEASTSSA1physical
19536198
SSB1_YEASTSSB1physical
22635919
HSP71_YEASTSSA1physical
22635919
HSP72_YEASTSSA2physical
22635919
HSP7F_YEASTSSE1genetic
23530227
RPOM_YEASTRPO41physical
23530227
SIS1_YEASTSIS1physical
23530227
HSP74_YEASTSSA4physical
23530227
SNL1_YEASTSNL1genetic
23530227
HSP7F_YEASTSSE1genetic
24671421
HSP71_YEASTSSA1physical
24671421
HSP72_YEASTSSA2physical
24671421
SSB1_YEASTSSB1physical
24671421
SSB2_YEASTSSB2physical
24671421
ACT_YEASTACT1genetic
27708008
CDC20_YEASTCDC20genetic
27708008
ZPR1_YEASTZPR1genetic
27708008
RRN7_YEASTRRN7genetic
27708008
AAKG_YEASTSNF4genetic
27708008
SLX9_YEASTSLX9genetic
27708008
YIH7_YEASTYIL077Cgenetic
27708008
CDC27_YEASTCDC27genetic
27708008
PRP9_YEASTPRP9genetic
27708008
RPN6_YEASTRPN6genetic
27708008
UAP1_YEASTQRI1genetic
27708008
KIN28_YEASTKIN28genetic
27708008
DAD1_YEASTDAD1genetic
27708008
DBF4_YEASTDBF4genetic
27708008
RLI1_YEASTRLI1genetic
27708008
CDC37_YEASTCDC37genetic
27708008
SP110_YEASTSPC110genetic
27708008
SYF1_YEASTSYF1genetic
27708008
RMRP_YEASTSNM1genetic
27708008
SMC1_YEASTSMC1genetic
27708008
MOB2_YEASTMOB2genetic
27708008
PMM_YEASTSEC53genetic
27708008
PSB7_YEASTPRE4genetic
27708008
ERG26_YEASTERG26genetic
27708008
PRS8_YEASTRPT6genetic
27708008
HSF_YEASTHSF1genetic
27708008
NUP57_YEASTNUP57genetic
27708008
RRP4_YEASTRRP4genetic
27708008
PRS7_YEASTRPT1genetic
27708008
CLF1_YEASTCLF1genetic
27708008
HAS1_YEASTHAS1genetic
27708008
PRP2_YEASTPRP2genetic
27708008
SGT1_YEASTSGT1genetic
27708008
PSA7_YEASTPRE10genetic
27708008
RDS3_YEASTRDS3genetic
27708008
PSB5_YEASTPRE2genetic
27708008
RPN7_YEASTRPN7genetic
27708008
HSP71_YEASTSSA1genetic
27708008
RBG1_YEASTRBG1genetic
27708008
STE50_YEASTSTE50genetic
27708008
NHP10_YEASTNHP10genetic
27708008
GET3_YEASTGET3genetic
27708008
GCST_YEASTGCV1genetic
27708008
TPS2_YEASTTPS2genetic
27708008
MNN10_YEASTMNN10genetic
27708008
RLA4_YEASTRPP2Bgenetic
27708008
RV167_YEASTRVS167genetic
27708008
GET2_YEASTGET2genetic
27708008
RIM15_YEASTRIM15genetic
27708008
FAR7_YEASTFAR7genetic
27708008
GET1_YEASTGET1genetic
27708008
YGY5_YEASTYGL235Wgenetic
27708008
NPR3_YEASTNPR3genetic
27708008
OCA5_YEASTOCA5genetic
27708008
PIH1_YEASTPIH1genetic
27708008
COX23_YEASTCOX23genetic
27708008
MRX5_YEASTYJL147Cgenetic
27708008
YJ24_YEASTKCH1genetic
27708008
PTK2_YEASTPTK2genetic
27708008
DOHH_YEASTLIA1genetic
27708008
MOG1_YEASTMOG1genetic
27708008
HOC1_YEASTHOC1genetic
27708008
LHS1_YEASTLHS1genetic
27708008
SAC1_YEASTSAC1genetic
27708008
NU133_YEASTNUP133genetic
27708008
UBR2_YEASTUBR2genetic
27708008
SWI6_YEASTSWI6genetic
27708008
COA4_YEASTCOA4genetic
27708008
ARV1_YEASTARV1genetic
27708008
MUB1_YEASTMUB1genetic
27708008
SCS7_YEASTSCS7genetic
27708008
AEP2_YEASTAEP2genetic
27708008
MAS5_YEASTYDJ1genetic
27708008
COQ2_YEASTCOQ2genetic
27708008
IRA2_YEASTIRA2genetic
27708008
STI1_YEASTSTI1genetic
27708008
NAT5_YEASTNAT5genetic
27708008
BEM4_YEASTBEM4genetic
27708008
COX10_YEASTCOX10genetic
27708008
YP225_YEASTYPL225Wgenetic
27708008
AP1G1_YEASTAPL4genetic
27708008
HSP7C_HUMANHSPA8physical
27107014
CCDB1_HUMANCCNDBP1physical
27107014
TRIM1_HUMANMID2physical
27107014
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of FES1_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-12, AND MASSSPECTROMETRY.

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