| UniProt ID | NU116_YEAST | |
|---|---|---|
| UniProt AC | Q02630 | |
| Protein Name | Nucleoporin NUP116/NSP116 | |
| Gene Name | NUP116 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 1113 | |
| Subcellular Localization |
Nucleus, nuclear pore complex. Nucleus membrane Peripheral membrane protein Cytoplasmic side. Nucleus membrane Peripheral membrane protein Nucleoplasmic side. Biased towards cytoplasmic side. |
|
| Protein Description | Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. Active directional transport is assured by both, a Phe-Gly (FG) repeat affinity gradient for these transport factors across the NPC and a transport cofactor concentration gradient across the nuclear envelope (GSP1 and GSP2 GTPases associated predominantly with GTP in the nucleus, with GDP in the cytoplasm). NUP116 plays an important role in several nuclear export and import pathways including poly(A)+ RNA, tRNA, pre-ribosome, and protein transport.. | |
| Protein Sequence | MFGVSRGAFPSATTQPFGSTGSTFGGQQQQQQPVANTSAFGLSQQTNTTQAPAFGNFGNQTSNSPFGMSGSTTANGTPFGQSQLTNNNASGSIFGGMGNNTALSAGSASVVPNSTAGTSIKPFTTFEEKDPTTGVINVFQSITCMPEYRNFSFEELRFQDYQAGRKFGTSQNGTGTTFNNPQGTTNTGFGIMGNNNSTTSATTGGLFGQKPATGMFGTGTGSGGGFGSGATNSTGLFGSSTNLSGNSAFGANKPATSGGLFGNTTNNPTNGTNNTGLFGQQNSNTNGGLFGQQQNSFGANNVSNGGAFGQVNRGAFPQQQTQQGSGGIFGQSNANANGGAFGQQQGTGALFGAKPASGGLFGQSAGSKAFGMNTNPTGTTGGLFGQTNQQQSGGGLFGQQQNSNAGGLFGQNNQSQNQSGLFGQQNSSNAFGQPQQQGGLFGSKPAGGLFGQQQGASTFASGNAQNNSIFGQNNQQQQSTGGLFGQQNNQSQSQPGGLFGQTNQNNNQPFGQNGLQQPQQNNSLFGAKPTGFGNTSLFSNSTTNQSNGISGNNLQQQSGGLFQNKQQPASGGLFGSKPSNTVGGGLFGNNQVANQNNPASTSGGLFGSKPATGSLFGGTNSTAPNASSGGIFGSNNASNTAATTNSTGLFGNKPVGAGASTSAGGLFGNNNNSSLNNSNGSTGLFGSNNTSQSTNAGGLFQNNTSTNTSGGGLFSQPSQSMAQSQNALQQQQQQQRLQIQNNNPYGTNELFSKATVTNTVSYPIQPSATKIKADERKKASLTNAYKMIPKTLFTAKLKTNNSVMDKAQIKVDPKLSISIDKKNNQIAISNQQEENLDESILKASELLFNPDKRSFKNLINNRKMLIASEEKNNGSQNNDMNFKSKSEEQETILGKPKMDEKETANGGERMVLSSKNDGEDSATKHHSRNMDEENKENVADLQKQEYSEDDKKAVFADVAEKDASFINENYYISPSLDTLSSYSLLQLRKVPHLVVGHKSYGKIEFLEPVDLAGIPLTSLGGVIITFEPKTCIIYANLPNRPKRGEGINVRARITCFNCYPVDKSTRKPIKDPNHQLVKRHIERLKKNPNSKFESYDADSGTYVFIVNHAAEQT | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 152 | Phosphorylation | MPEYRNFSFEELRFQ CHHHCCCCHHHHEEC | 34.98 | 22890988 | |
| 239 | Phosphorylation | NSTGLFGSSTNLSGN CCCCCCCCCCCCCCC | 27.01 | 21551504 | |
| 241 | Phosphorylation | TGLFGSSTNLSGNSA CCCCCCCCCCCCCCC | 41.71 | 21551504 | |
| 357 | Phosphorylation | LFGAKPASGGLFGQS CCCCEECCCCCCCCC | 41.75 | 27214570 | |
| 755 | Phosphorylation | NELFSKATVTNTVSY HHHCCCCEEEEEECC | 31.44 | 27017623 | |
| 757 | Phosphorylation | LFSKATVTNTVSYPI HCCCCEEEEEECCCC | 22.33 | 27017623 | |
| 767 | Phosphorylation | VSYPIQPSATKIKAD ECCCCCCCCCCCCHH | 31.99 | 27017623 | |
| 769 | Phosphorylation | YPIQPSATKIKADER CCCCCCCCCCCHHHH | 37.33 | 27017623 | |
| 796 | Acetylation | PKTLFTAKLKTNNSV CHHHHEEECCCCCCC | 47.67 | 23572591 | |
| 814 | Acetylation | AQIKVDPKLSISIDK HHEECCCCCEEEEEC | 50.86 | 24489116 | |
| 816 | Phosphorylation | IKVDPKLSISIDKKN EECCCCCEEEEECCC | 22.03 | 28889911 | |
| 818 | Phosphorylation | VDPKLSISIDKKNNQ CCCCCEEEEECCCCE | 22.74 | 24961812 | |
| 852 | Acetylation | ELLFNPDKRSFKNLI HHHHCCCHHHHHHHH | 51.72 | 24489116 | |
| 875 | Phosphorylation | SEEKNNGSQNNDMNF ECCCCCCCCCCCCCC | 31.68 | 30377154 | |
| 884 | Phosphorylation | NNDMNFKSKSEEQET CCCCCCCCCCHHHHH | 36.96 | 27214570 | |
| 886 | Phosphorylation | DMNFKSKSEEQETIL CCCCCCCCHHHHHHC | 54.15 | 29136822 | |
| 921 | Phosphorylation | SKNDGEDSATKHHSR ECCCCCCHHHHHHCC | 33.27 | 24930733 | |
| 923 | Phosphorylation | NDGEDSATKHHSRNM CCCCCHHHHHHCCCC | 34.56 | 24961812 | |
| 927 | Phosphorylation | DSATKHHSRNMDEEN CHHHHHHCCCCCHHH | 25.68 | 27717283 | |
| 947 | Phosphorylation | DLQKQEYSEDDKKAV HHHHHHCCHHHHHHH | 33.52 | 21440633 | |
| 970 | Phosphorylation | ASFINENYYISPSLD HHHCCCCCEECCCHH | 8.94 | 28132839 | |
| 971 | Phosphorylation | SFINENYYISPSLDT HHCCCCCEECCCHHH | 13.40 | 28132839 | |
| 1091 | Acetylation | LKKNPNSKFESYDAD HHHCCCCCCCEEECC | 60.84 | 24489116 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of NU116_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of NU116_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of NU116_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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