TR732_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TR732_YEAST
• UniProt AC: Q03496
• Protein Name: tRNA (cytidine(32)-2'-O)-methyltransferase non-catalytic subunit TRM732
• Gene Name: TRM732
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 1420
• Subcellular Localization: Cytoplasm .
• Protein Description: Required together with TRM7 for the methylation of the 2'-O-ribose of cytidine at position 32 of the tRNA anticodon loop of tRNA(Phe) and tRNA(Leu(UAA))..
• Protein Sequence: MTTDVQFSSQEIELFRVKEFLIANNPAKINNENKDAVLTQIEHDFRYLIQYIKDGLPNLNESTRLIFPDTFSICLLRSHQIIASKKIDSQEFLSAVKEQLLTEANANIIFEYVLDFWADGGAPLMNALRDLFSKLLNLLKITYPMSTLKDVLFNWMNEILEVPSTLRVQYYLIDALSSDFDLYYIIEKKPHFIDNSFSLMNSDLLANSVGKCIVSLLLNIYEKHFKKNESFVQEWIQLWKSCALKYIHDKQYTKSINLYIMIPLFKNMPNSAFTLFLECMSNKDPSLLLSLLKIGQELGIEEEPFCDNKYTTVDSVNKLIEQDEYKLQVFEILTFSTKKSKPIRPFVFKTIKQYLYVFFVDTELERRNYFCSSMKHFIFRTRDCAYSLARDARKLKKAEKFPDEQREKLAQVEEARAFLVWLCNFIKYNLAPGTLYQANVTSLKLMHILIKSGVDKSTPQKFLDNQNKREYPFSIPILQDVTFLRLLIDLLVSNYADVRELSKEMLFIMISADESRGLFLDTLDANALKWTATSLLSDYEKGDAGATVYEFIFTVMGSQRSFIDQTIDILAQMVQNLQNDSIGCAENSIGPHFAALSLILNKFNSEENHQDTSKIISKLINLVLKSWEATRNVVCHDSAHGILPEKYANCGVPDQVIISHAFRAIKEASYLLETILKKYPLTRDQLDSIGDLFIVQLSTIRHSGAFQAVLPGLKAFCIRCQLEFPAILEELLSKSVKSLKSKTQHITRRSGGLPFLVTTVLSAEVTKGRPLLQKTFENLLLVARLPIPPHQDEFDLPQVNAINCINAIFVEPKLSVHCTSFVSEALELALLNFDCDIWALRNCSIMLFTSLQNRIFGKVGRSVSAKLFFTKYSGLRQLLLNILNSSIAQYSGSERKSYQIESIFLVLNVLLRLRPTAGYTGLKEFNVSVYECLSNENWKIRDMASRVLHMLSENFEEEIRKLLDLASIAKQNQLHGHLLALQQLVPQYLSGTRDMELIQRILEKKRMLLLENKCFITKKAYLKLTCCILETCDIPDSILKDYISTLRNTFIAENNEYVVDGSKQLYLAQILDMLLKYEDSIYLDDICLLGLYSPFYEAQLSTLQYMNTNFHWETTRNSEFLEQLQLLLRVPDLLPMAKALVVKILSRKKNTLSLTTCTDLLKTNNSEDTKLAAVSSLSAKLSSQTFHQVWNLLQGFFADSCSKDFRLASLECLTAYPESCKNSRILLQLYNFLWDDDSEIREKASFYLNKNFIQTADWEYNRNTSVTALIFTKKFVDVFTSSEVVEELCLQLFQYLNEYDMFAAEESAKNCLFTIEKDNQFINELQKAMHILNMIKLTGRDISKCYKDQIHHLKSALLEHFNTEDFKDSPLGWCSNAEIFSRITLLKELIQHYSPSDYENFINVLTKHSVHPLIISYSQL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
669	Phosphorylation	FRAIKEASYLLETIL HHHHHHHHHHHHHHH		27214570
674	Phosphorylation	EASYLLETILKKYPL HHHHHHHHHHHHCCC		27214570
871	Acetylation	SAKLFFTKYSGLRQL HHHHHCCCCHHHHHH		24489116
967	Phosphorylation	RKLLDLASIAKQNQL HHHHHHHHHHHHCCC		28152593
1148	Acetylation	VVKILSRKKNTLSLT HHHHHHCCCCEEEEE		24489116
1170	Ubiquitination	TNNSEDTKLAAVSSL HCCCHHHHHHHHHHH		23749301
1221	Ubiquitination	TAYPESCKNSRILLQ HHCCHHHCCCHHHHH		23749301
1338	Phosphorylation	ILNMIKLTGRDISKC HHHHHHHHCCCHHHH		27017623
1343	Phosphorylation	KLTGRDISKCYKDQI HHHCCCHHHHHHHHH		27017623

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TR732_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TR732_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TR732_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TRM7_YEAST	TRM7	physical	16554755
ATR_YEAST	MEC1	physical	16554755
LSB3_YEAST	LSB3	physical	16554755
CG21_YEAST	CLB1	physical	16554755
G3P2_YEAST	TDH2	physical	16554755
UTP21_YEAST	UTP21	physical	16554755
CUE5_YEAST	CUE5	physical	16554755
HSP71_YEAST	SSA1	physical	19536198
SSB1_YEAST	SSB1	physical	19536198
WDR6_YEAST	RTT10	genetic	22912484

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.