| UniProt ID | ROY1_YEAST | |
|---|---|---|
| UniProt AC | Q04847 | |
| Protein Name | Non-SCF-type F-box protein ROY1 | |
| Gene Name | ROY1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 553 | |
| Subcellular Localization |
Cytoplasm. Nucleus. Cytoplasmic vesicle membrane Peripheral membrane protein. |
|
| Protein Description | Non-SCF-type F-box protein involved in the endocytic with the vacuolar sorting pathway. Acts as a repressor of YPT52 by inhibiting the formation of active, GTP-bound, YPT52. Involved in the defense mechanism against methylmercury toxicity.. | |
| Protein Sequence | MAFQDQDIFIVFSHASLFLNQNDLLSLSLTSKKMHDMIAIPRLYSNIHITKNPVLRTNKWFLDGGKTYVSGYRSVLKTGDKNDIFLYDRIERLLETSHLKCIKQLTIDEDLFHNREEGLQLLQRLVNEITDLDVIESLDIKDPTLFELCSAKYYRLSSLKKRVVYGETGFDGIKLWQNFKSLKWQLPESLDLQNVIIPEVGVMLMKQLNGGELEIKDEAYSSLRVFEYFDSLNLRFKNLRRLKLNHVHKQGDGSATSMRLSSRAFKDVVNLSNLKALELEFSCEVDDCECDDDFLQDITGNLVSLTSLGFIEKTFTKKGYHYMDEKWDLVVNKFILNLPNVSKDLRLLSIRHDPPLNGKGIDTVDGNLLRRKKLYEKVLPKLTSLETIIAPTVLQSITSYEMYACDLLWNGCKCAFCSKYLPLFDKYIMNHQYFSTPDARYLDIIPIVFAAYTGKSLAKRFDPQKNWDLDLLQYAPEDTTWNFHGFERIHHFASYECYFDESSFEPLATIISHFFYPYMNYLIKILPNLRQTMLSGIYFSVSPELHTYETIYD | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 256 | Phosphorylation | KQGDGSATSMRLSSR CCCCCCHHHHHHHHH | 25.42 | 28889911 | |
| 257 | Phosphorylation | QGDGSATSMRLSSRA CCCCCHHHHHHHHHH | 11.13 | 28889911 | |
| 377 | Acetylation | RRKKLYEKVLPKLTS HHHHHHHHHHHHCCC | 35.20 | 24489116 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of ROY1_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of ROY1_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of ROY1_YEAST !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| SKP1_YEAST | SKP1 | physical | 16554755 | |
| YPT52_YEAST | YPT52 | physical | 16554755 | |
| SKP1_YEAST | SKP1 | physical | 16429126 | |
| YPT52_YEAST | YPT52 | physical | 16429126 | |
| YPT52_YEAST | YPT52 | physical | 21389113 | |
| SKP1_YEAST | SKP1 | physical | 21389113 | |
| SEC7_YEAST | SEC7 | genetic | 27708008 | |
| CDC48_YEAST | CDC48 | genetic | 27708008 | |
| SC61G_YEAST | SSS1 | genetic | 27708008 | |
| ERF3_YEAST | SUP35 | genetic | 27708008 | |
| ORC1_YEAST | ORC1 | genetic | 27708008 | |
| MED11_YEAST | MED11 | genetic | 27708008 | |
| MED10_YEAST | NUT2 | genetic | 27708008 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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