| UniProt ID | BAR1_YEAST | |
|---|---|---|
| UniProt AC | P12630 | |
| Protein Name | Barrierpepsin | |
| Gene Name | BAR1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 587 | |
| Subcellular Localization | Secreted. | |
| Protein Description | This protein called "barrier activity" is excreted by yeast cells mating type a. It is probably a protease that cleaves alpha-factor and thus acts as an antagonist of this mating pheromone and establishes optimal pheromone concentration for conjugation.. | |
| Protein Sequence | MSAINHLCLKLILASFAIINTITALTNDGTGHLEFLLQHEEEMYYATTLDIGTPSQSLTVLFDTGSADFWVMDSSNPFCLPNSNTSSYSNATYNGEEVKPSIDCRSMSTYNEHRSSTYQYLENGRFYITYADGTFADGSWGTETVSINGIDIPNIQFGVAKYATTPVSGVLGIGFPRRESVKGYEGAPNEYYPNFPQILKSEKIIDVVAYSLFLNSPDSGTGSIVFGAIDESKFSGDLFTFPMVNEYPTIVDAPATLAMTIQGLGAQNKSSCEHETFTTTKYPVLLDSGTSLLNAPKVIADKMASFVNASYSEEEGIYILDCPVSVGDVEYNFDFGDLQISVPLSSLILSPETEGSYCGFAVQPTNDSMVLGDVFLSSAYVVFDLDNYKISLAQANWNASEVSKKLVNIQTDGSISGAKIATAEPWSTNEPFTVTSDIYSSTGCKSRPFLQSSTASSLIAETNVQSRNCSTKMPGTRSTTVLSKPTQNSAMHQSTGAVTQTSNETKLELSSTMANSGSVSLPTSNSIDKEFEHSKSQTTSDPSVAEHSTFNQTFVHETKYRPTHKTVITETVTKYSTVLINVCKPTY | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | O-linked_Glycosylation | ------MSAINHLCL ------CCHHHHHHH | 37.54 | OGP | |
| 21 | O-linked_Glycosylation | ASFAIINTITALTND HHHHHHHHHHHHCCC | 14.86 | OGP | |
| 48 | O-linked_Glycosylation | EEMYYATTLDIGTPS HHEEEEEEECCCCCC | 17.79 | OGP | |
| 57 | O-linked_Glycosylation | DIGTPSQSLTVLFDT CCCCCCCCEEEEEEC | 30.28 | 7559601 | |
| 74 | O-linked_Glycosylation | ADFWVMDSSNPFCLP CCEEEECCCCCEECC | 17.58 | 7559601 | |
| 75 | O-linked_Glycosylation | DFWVMDSSNPFCLPN CEEEECCCCCEECCC | 44.23 | OGP | |
| 83 | O-linked_Glycosylation | NPFCLPNSNTSSYSN CCEECCCCCCCCCCC | 39.27 | OGP | |
| 84 | N-linked_Glycosylation | PFCLPNSNTSSYSNA CEECCCCCCCCCCCC | 51.09 | - | |
| 87 | O-linked_Glycosylation | LPNSNTSSYSNATYN CCCCCCCCCCCCEEC | 30.46 | 7559601 | |
| 90 | N-linked_Glycosylation | SNTSSYSNATYNGEE CCCCCCCCCEECCCC | 28.24 | - | |
| 92 | O-linked_Glycosylation | TSSYSNATYNGEEVK CCCCCCCEECCCCCC | 23.05 | 7559601 | |
| 101 | O-linked_Glycosylation | NGEEVKPSIDCRSMS CCCCCCCCCCCCCCC | 25.91 | OGP | |
| 115 | O-linked_Glycosylation | STYNEHRSSTYQYLE CCCCCCCCCEEEEEC | 29.01 | 7559601 | |
| 116 | O-linked_Glycosylation | TYNEHRSSTYQYLEN CCCCCCCCEEEEECC | 30.96 | OGP | |
| 139 | O-linked_Glycosylation | DGTFADGSWGTETVS CCCCCCCCCCCEEEE | 23.91 | 7559601 | |
| 144 | O-linked_Glycosylation | DGSWGTETVSINGID CCCCCCEEEEECCEE | 21.28 | 7559601 | |
| 162 | Phosphorylation | IQFGVAKYATTPVSG EEEECEEEECCCCCC | 10.23 | 26447709 | |
| 164 | Phosphorylation | FGVAKYATTPVSGVL EECEEEECCCCCCCE | 28.66 | 26447709 | |
| 165 | Phosphorylation | GVAKYATTPVSGVLG ECEEEECCCCCCCEE | 17.33 | 26447709 | |
| 168 | Phosphorylation | KYATTPVSGVLGIGF EEECCCCCCCEECCC | 25.12 | 26447709 | |
| 268 | N-linked_Glycosylation | IQGLGAQNKSSCEHE HHCCCCCCCCCCCCC | 45.72 | - | |
| 271 | O-linked_Glycosylation | LGAQNKSSCEHETFT CCCCCCCCCCCCCEE | 25.74 | 7559601 | |
| 308 | N-linked_Glycosylation | DKMASFVNASYSEEE HHHHHHHCCCCCCCC | 22.59 | - | |
| 366 | N-linked_Glycosylation | GFAVQPTNDSMVLGD CEEEECCCCCEEHHH | 46.15 | - | |
| 391 | O-linked_Glycosylation | DLDNYKISLAQANWN ECCCCEEEEEECCCC | 17.32 | 7559601 | |
| 398 | N-linked_Glycosylation | SLAQANWNASEVSKK EEEECCCCHHHHHHH | 33.14 | - | |
| 400 | O-linked_Glycosylation | AQANWNASEVSKKLV EECCCCHHHHHHHHC | 35.00 | 7559601 | |
| 403 | O-linked_Glycosylation | NWNASEVSKKLVNIQ CCCHHHHHHHHCCEE | 21.74 | 7559601 | |
| 411 | Phosphorylation | KKLVNIQTDGSISGA HHHCCEECCCCCCCC | 38.23 | 27017623 | |
| 411 | O-linked_Glycosylation | KKLVNIQTDGSISGA HHHCCEECCCCCCCC | 38.23 | 7559601 | |
| 414 | Phosphorylation | VNIQTDGSISGAKIA CCEECCCCCCCCEEE | 19.18 | 27017623 | |
| 414 | O-linked_Glycosylation | VNIQTDGSISGAKIA CCEECCCCCCCCEEE | 19.18 | 7559601 | |
| 416 | O-linked_Glycosylation | IQTDGSISGAKIATA EECCCCCCCCEEEEC | 34.10 | 7559601 | |
| 422 | O-linked_Glycosylation | ISGAKIATAEPWSTN CCCCEEEECCCCCCC | 34.72 | 7559601 | |
| 427 | O-linked_Glycosylation | IATAEPWSTNEPFTV EEECCCCCCCCCEEE | 31.88 | 7559601 | |
| 428 | O-linked_Glycosylation | ATAEPWSTNEPFTVT EECCCCCCCCCEEEE | 39.47 | 7559601 | |
| 433 | O-linked_Glycosylation | WSTNEPFTVTSDIYS CCCCCCEEEECEECC | 33.32 | - | |
| 442 | O-linked_Glycosylation | TSDIYSSTGCKSRPF ECEECCCCCCCCCCC | 40.43 | 7559601 | |
| 446 | O-linked_Glycosylation | YSSTGCKSRPFLQSS CCCCCCCCCCCCCCC | 49.62 | 7559601 | |
| 452 | O-linked_Glycosylation | KSRPFLQSSTASSLI CCCCCCCCCCCHHHH | 31.63 | 7559601 | |
| 453 | O-linked_Glycosylation | SRPFLQSSTASSLIA CCCCCCCCCCHHHHH | 18.29 | - | |
| 453 | Phosphorylation | SRPFLQSSTASSLIA CCCCCCCCCCHHHHH | 18.29 | 27017623 | |
| 454 | O-linked_Glycosylation | RPFLQSSTASSLIAE CCCCCCCCCHHHHHH | 35.49 | 7559601 | |
| 456 | Phosphorylation | FLQSSTASSLIAETN CCCCCCCHHHHHHCC | 26.26 | 27017623 | |
| 456 | O-linked_Glycosylation | FLQSSTASSLIAETN CCCCCCCHHHHHHCC | 26.26 | 7559601 | |
| 457 | Phosphorylation | LQSSTASSLIAETNV CCCCCCHHHHHHCCC | 22.72 | 27017623 | |
| 457 | O-linked_Glycosylation | LQSSTASSLIAETNV CCCCCCHHHHHHCCC | 22.72 | 7559601 | |
| 462 | O-linked_Glycosylation | ASSLIAETNVQSRNC CHHHHHHCCCCCCCC | 31.50 | 7559601 | |
| 466 | O-linked_Glycosylation | IAETNVQSRNCSTKM HHHCCCCCCCCCCCC | 22.60 | - | |
| 468 | N-linked_Glycosylation | ETNVQSRNCSTKMPG HCCCCCCCCCCCCCC | 29.36 | - | |
| 470 | O-linked_Glycosylation | NVQSRNCSTKMPGTR CCCCCCCCCCCCCCC | 34.31 | 7559601 | |
| 471 | O-linked_Glycosylation | VQSRNCSTKMPGTRS CCCCCCCCCCCCCCC | 33.30 | - | |
| 476 | O-linked_Glycosylation | CSTKMPGTRSTTVLS CCCCCCCCCCEEEEC | 18.64 | 7559601 | |
| 478 | O-linked_Glycosylation | TKMPGTRSTTVLSKP CCCCCCCCEEEECCC | 28.41 | 7559601 | |
| 479 | O-linked_Glycosylation | KMPGTRSTTVLSKPT CCCCCCCEEEECCCC | 20.03 | 7559601 | |
| 480 | O-linked_Glycosylation | MPGTRSTTVLSKPTQ CCCCCCEEEECCCCC | 22.24 | 7559601 | |
| 483 | O-linked_Glycosylation | TRSTTVLSKPTQNSA CCCEEEECCCCCCCC | 32.05 | 7559601 | |
| 486 | O-linked_Glycosylation | TTVLSKPTQNSAMHQ EEEECCCCCCCCCCC | 44.08 | 7559601 | |
| 489 | O-linked_Glycosylation | LSKPTQNSAMHQSTG ECCCCCCCCCCCCCC | 19.70 | 7559601 | |
| 494 | Phosphorylation | QNSAMHQSTGAVTQT CCCCCCCCCCCEEEC | 17.71 | 19779198 | |
| 494 | O-linked_Glycosylation | QNSAMHQSTGAVTQT CCCCCCCCCCCEEEC | 17.71 | - | |
| 495 | O-linked_Glycosylation | NSAMHQSTGAVTQTS CCCCCCCCCCEEECC | 23.69 | 7559601 | |
| 495 | Phosphorylation | NSAMHQSTGAVTQTS CCCCCCCCCCEEECC | 23.69 | 19779198 | |
| 499 | O-linked_Glycosylation | HQSTGAVTQTSNETK CCCCCCEEECCCCCE | 26.12 | 7559601 | |
| 499 | Phosphorylation | HQSTGAVTQTSNETK CCCCCCEEECCCCCE | 26.12 | 19779198 | |
| 501 | O-linked_Glycosylation | STGAVTQTSNETKLE CCCCEEECCCCCEEE | 24.93 | 7559601 | |
| 502 | O-linked_Glycosylation | TGAVTQTSNETKLEL CCCEEECCCCCEEEE | 23.89 | - | |
| 503 | N-linked_Glycosylation | GAVTQTSNETKLELS CCEEECCCCCEEEEE | 65.43 | - | |
| 512 | O-linked_Glycosylation | TKLELSSTMANSGSV CEEEEECCCCCCCCC | 19.54 | 7559601 | |
| 516 | O-linked_Glycosylation | LSSTMANSGSVSLPT EECCCCCCCCCCCCC | 23.94 | 7559601 | |
| 518 | O-linked_Glycosylation | STMANSGSVSLPTSN CCCCCCCCCCCCCCC | 14.35 | - | |
| 520 | O-linked_Glycosylation | MANSGSVSLPTSNSI CCCCCCCCCCCCCCC | 30.26 | - | |
| 551 | N-linked_Glycosylation | VAEHSTFNQTFVHET HHHHCCCCCCEEEEC | 39.82 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of BAR1_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of BAR1_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of BAR1_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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