| UniProt ID | NAM7_YEAST | |
|---|---|---|
| UniProt AC | P30771 | |
| Protein Name | ATP-dependent helicase NAM7 | |
| Gene Name | NAM7 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 971 | |
| Subcellular Localization | Cytoplasm. Nucleus. Present predominantly in the cytoplasm, but is also found in small quantities in the nucleus. | |
| Protein Description | Probable helicase involved in mitochondrial functions. Required for rapid turnover of mRNAs containing a premature translational termination codon.. | |
| Protein Sequence | MVGSGSHTPYDISNSPSDVNVQPATQLNSTLVEDDDVDNQLFEEAQVTETGFRSPSASDNSCAYCGIDSAKCVIKCNSCKKWFCNTKNGTSSSHIVNHLVLSHHNVVSLHPDSDLGDTVLECYNCGRKNVFLLGFVSAKSEAVVVLLCRIPCAQTKNANWDTDQWQPLIEDRQLLSWVAEQPTEEEKLKARLITPSQISKLEAKWRSNKDATINDIDAPEEQEAIPPLLLRYQDAYEYQRSYGPLIKLEADYDKQLKESQALEHISVSWSLALNNRHLASFTLSTFESNELKVAIGDEMILWYSGMQHPDWEGRGYIVRLPNSFQDTFTLELKPSKTPPPTHLTTGFTAEFIWKGTSYDRMQDALKKFAIDKKSISGYLYYKILGHQVVDISFDVPLPKEFSIPNFAQLNSSQSNAVSHVLQRPLSLIQGPPGTGKTVTSATIVYHLSKIHKDRILVCAPSNVAVDHLAAKLRDLGLKVVRLTAKSREDVESSVSNLALHNLVGRGAKGELKNLLKLKDEVGELSASDTKRFVKLVRKTEAEILNKADVVCCTCVGAGDKRLDTKFRTVLIDESTQASEPECLIPIVKGAKQVILVGDHQQLGPVILERKAADAGLKQSLFERLISLGHVPIRLEVQYRMNPYLSEFPSNMFYEGSLQNGVTIEQRTVPNSKFPWPIRGIPMMFWANYGREEISANGTSFLNRIEAMNCERIITKLFRDGVKPEQIGVITPYEGQRAYILQYMQMNGSLDKDLYIKVEVASVDAFQGREKDYIILSCVRANEQQAIGFLRDPRRLNVGLTRAKYGLVILGNPRSLARNTLWNHLLIHFREKGCLVEGTLDNLQLCTVQLVRPQPRKTERPMNAQFNVESEMGDFPKFQDFDAQSMVSFSGQIGDFGNAFVDNTELSSYINNEYWNFENFKSAFSQKQNRNEIDDRNLYQEEASHLNSNFARELQREEQKHELSKDFSNLGI | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 54 | Phosphorylation | VTETGFRSPSASDNS EECCCCCCCCCCCCC | 22.42 | 28889911 | |
| 56 | Phosphorylation | ETGFRSPSASDNSCA CCCCCCCCCCCCCCC | 41.47 | 23749301 | |
| 58 | Phosphorylation | GFRSPSASDNSCAYC CCCCCCCCCCCCCCC | 41.48 | 27214570 | |
| 156 | Ubiquitination | RIPCAQTKNANWDTD ECCCCCCCCCCCCCC | 41.82 | 17644757 | |
| 194 | Phosphorylation | KLKARLITPSQISKL HHHHHEECHHHHHHH | 22.83 | 27214570 | |
| 196 | Phosphorylation | KARLITPSQISKLEA HHHEECHHHHHHHHH | 31.34 | 27214570 | |
| 199 | Phosphorylation | LITPSQISKLEAKWR EECHHHHHHHHHHHH | 24.45 | 27214570 | |
| 209 | Ubiquitination | EAKWRSNKDATINDI HHHHHCCCCCCCCCC | 50.41 | 17644757 | |
| 356 | Phosphorylation | AEFIWKGTSYDRMQD EEEEECCCCHHHHHH | 22.01 | 27017623 | |
| 357 | Phosphorylation | EFIWKGTSYDRMQDA EEEECCCCHHHHHHH | 33.43 | 27017623 | |
| 358 | Phosphorylation | FIWKGTSYDRMQDAL EEECCCCHHHHHHHH | 13.86 | 27017623 | |
| 471 | Ubiquitination | AVDHLAAKLRDLGLK HHHHHHHHHHHCCCE | 38.15 | 17644757 | |
| 471 | Acetylation | AVDHLAAKLRDLGLK HHHHHHHHHHHCCCE | 38.15 | 22865919 | |
| 485 | Ubiquitination | KVVRLTAKSREDVES EEEEEECCCHHHHHH | 44.82 | 17644757 | |
| 492 | Phosphorylation | KSREDVESSVSNLAL CCHHHHHHHHHHHHH | 35.57 | 28889911 | |
| 495 | Phosphorylation | EDVESSVSNLALHNL HHHHHHHHHHHHHHH | 28.24 | 28889911 | |
| 715 | Acetylation | NCERIITKLFRDGVK CHHHHHHHHHHCCCC | 34.91 | 24489116 | |
| 722 | Ubiquitination | KLFRDGVKPEQIGVI HHHHCCCCHHHEEEE | 48.65 | 23749301 | |
| 738 | Phosphorylation | PYEGQRAYILQYMQM CCCCCHHHHHHHHHH | 12.35 | 27017623 | |
| 761 | Phosphorylation | YIKVEVASVDAFQGR EEEEEEEECCCCCCC | 26.21 | 19779198 | |
| 857 | Phosphorylation | VRPQPRKTERPMNAQ ECCCCCCCCCCCCEE | 38.21 | 28889911 | |
| 869 | Phosphorylation | NAQFNVESEMGDFPK CEECCCCCCCCCCCC | 28.71 | 17330950 | |
| 924 | Phosphorylation | ENFKSAFSQKQNRNE HHHHHHHHHHCCCCC | 35.86 | 23749301 | |
| 926 | Ubiquitination | FKSAFSQKQNRNEID HHHHHHHHCCCCCCC | 48.63 | 23749301 | |
| 943 | Phosphorylation | NLYQEEASHLNSNFA HHHHHHHHHHHHHHH | 31.61 | 23749301 | |
| 947 | Phosphorylation | EEASHLNSNFARELQ HHHHHHHHHHHHHHH | 39.42 | 28889911 | |
| 967 | Phosphorylation | HELSKDFSNLGI--- HHHCHHHHHCCC--- | 41.08 | 30377154 |
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of NAM7_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of NAM7_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-54; SER-56; SER-495 ANDSER-869, AND MASS SPECTROMETRY. | |
| "Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae."; Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.; J. Proteome Res. 6:1190-1197(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-869, AND MASSSPECTROMETRY. | |
