dbPTM

GAS2_YEAST - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	GAS2_YEAST
UniProt AC	Q06135
Protein Name	1,3-beta-glucanosyltransferase GAS2
Gene Name	GAS2
Organism	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length	555
Subcellular Localization	Cell membrane Lipid-anchor, GPI-anchor.
Protein Description	Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall. Involved in spore wall assembly..
Protein Sequence	MNKKQNFYAAIIVAIFLCLQLSHGSSGVSFEKTPAIKIVGNKFFDSESGEQFFIKGIAYQLQRSEEELSNANGAFETSYIDALADPKICLRDIPFLKMLGVNTLRVYAIDPTKSHDICMEALSAEGMYVLLDLSEPDISINRENPSWDVHIFERYKSVIDAMSSFPNLLGYFAGNEVTNDHTNTFASPFVKAAIRDAKEYISHSNHRKIPVGYSTNDDAMTRDNLARYFVCGDVKADFYGINMYEWCGYSTYGTSGYRERTKEFEGYPIPVFFSEFGCNLVRPRPFTEVSALYGNKMSSVWSGGLAYMYFEEENEYGVVKINDNDGVDILPDFKNLKKEFAKADPKGITEEEYLTAKEPTEVESVECPHIAVGVWEANEKLPETPDRSKCACLDEILPCEIVPFGAESGKYEEYFSYLCSKVDCSDILANGKTGEYGEFSDCSVEQKLSLQLSKLYCKIGANDRHCPLNDKNVYFNLESLQPLTSESICKNVFDSIRNITYNHGDYSKSNPSRSKESLNVKYPSSEERENDGTIAFKTSGFVILLISMIAAGILL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
474	Phosphorylation	PLNDKNVYFNLESLQ CCCCCCEEEEHHHCC	8.99	28889911
487	Phosphorylation	LQPLTSESICKNVFD CCCCCCHHHHHHHHH	32.81	25371407
498	N-linked_Glycosylation	NVFDSIRNITYNHGD HHHHHHHCCCCCCCC	29.32	-
531	GPI-anchor	SSEERENDGTIAFKT CHHHCCCCCEEEEEH	51.35	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of GAS2_YEAST !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of GAS2_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of GAS2_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GAS4_YEAST	GAS4	genetic	17189486
PDX3_YEAST	PDX3	genetic	21623372
ARO1_YEAST	ARO1	genetic	21623372
THDH_YEAST	ILV1	genetic	21623372
ODPA_YEAST	PDA1	genetic	21623372
ADH3_YEAST	ADH3	genetic	21623372
FOLE_YEAST	MET7	genetic	21623372
GSH1_YEAST	GSH1	genetic	21623372
GGPPS_YEAST	BTS1	genetic	21623372
HXKB_YEAST	HXK2	genetic	21623372
COQ3_YEAST	COQ3	genetic	21623372
GAS4_YEAST	GAS4	genetic	21623372
HSP71_YEAST	SSA1	physical	22940862
EF1A_YEAST	TEF2	physical	22940862
MAS5_YEAST	YDJ1	physical	22940862
HSP72_YEAST	SSA2	physical	22940862
SSB1_YEAST	SSB1	physical	22940862
BCK1_YEAST	BCK1	genetic	23891562
SOL2_YEAST	SOL2	genetic	27708008
YCQ6_YEAST	YCR016W	genetic	27708008
RS16A_YEAST	RPS16B	genetic	27708008
RS16B_YEAST	RPS16B	genetic	27708008
CYPD_YEAST	CPR5	genetic	27708008
MNT2_YEAST	MNT2	genetic	27708008
RS25A_YEAST	RPS25A	genetic	27708008
PHB2_YEAST	PHB2	genetic	27708008
ATG32_YEAST	ATG32	genetic	27708008
RL1D1_YEAST	UTP30	genetic	27708008
MAC1_YEAST	MAC1	genetic	27708008
RIM13_YEAST	RIM13	genetic	27708008
HRB1_YEAST	HRB1	genetic	27708008
KIN4_YEAST	KIN4	genetic	27708008
PRM4_YEAST	PRM4	genetic	27708008
UBA3_YEAST	UBA3	genetic	27708008
RL36A_YEAST	RPL36A	genetic	29158977
DOM34_YEAST	DOM34	genetic	29158977

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of GAS2_YEAST

Related Literatures of Post-Translational Modification