UBC12_YEAST - dbPTM
UBC12_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID UBC12_YEAST
UniProt AC P52491
Protein Name NEDD8-conjugating enzyme UBC12
Gene Name UBC12
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 188
Subcellular Localization
Protein Description Accepts the ubiquitin-like protein NEDD8/RUB1 from the UBA3-ULA1 E1 complex and catalyzes its covalent attachment to other proteins. The major substrate is CDC53/Cullin..
Protein Sequence MLKLRQLQKKKQKENENSSSIQPNLSAARIRLKRDLDSLDLPPTVTLNVITSPDSADRSQSPKLEVIVRPDEGYYNYGSINFNLDFNEVYPIEPPKVVCLKKIFHPNIDLKGNVCLNILREDWSPALDLQSIITGLLFLFLEPNPNDPLNKDAAKLLCEGEKEFAEAVRLTMSGGSIEHVKYDNIVSP
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
1Acetylation-------MLKLRQLQ
-------CCHHHHHH		7.2221940857
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of UBC12_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference
1MAcetylation

21940857
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of UBC12_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
ULA1_YEASTULA1physical
11805837
RPB1_YEASTRPO21genetic
17314980
IRC20_YEASTIRC20genetic
17314980
DOA1_YEASTDOA1genetic
17314980
REI1_YEASTREI1genetic
17314980
MED31_YEASTSOH1genetic
17314980
DCN1_YEASTDCN1physical
18206966
RBX1_YEASTHRT1physical
21816351
TFB3_YEASTTFB3physical
21816351
DCN1_YEASTDCN1physical
21940857
UBA1_YEASTUBA1physical
21940857
RAD17_YEASTRAD17genetic
23273983
CDC53_YEASTCDC53physical
19942853
RSP5_YEASTRSP5physical
24821572
APC11_YEASTAPC11genetic
27708008
SWC5_YEASTSWC5genetic
27708008
ATG15_YEASTATG15genetic
27708008
MIC19_YEASTMIC19genetic
27708008
TBP7_YEASTYTA7genetic
27708008
AIM18_YEASTAIM18genetic
27708008
MPCP_YEASTMIR1genetic
27708008
CSI1_YEASTCSI1genetic
27708008
SIW14_YEASTSIW14genetic
27708008
PMS1_YEASTPMS1genetic
27708008
NCBP2_YEASTCBC2genetic
27708008
RFA1_YEASTRFA1genetic
27708008
DPOD_YEASTPOL3genetic
27708008
CDC53_YEASTCDC53genetic
27708008
TIM22_YEASTTIM22genetic
27708008
UBC3_YEASTCDC34genetic
27708008
CDC4_YEASTCDC4genetic
27708008
MOB2_YEASTMOB2genetic
27708008
RPN11_YEASTRPN11genetic
27708008
RPN12_YEASTRPN12genetic
27708008
DAM1_YEASTDAM1genetic
27708008
PTI1_YEASTPTI1genetic
27708008
STS1_YEASTSTS1genetic
27708008
DPOD2_YEASTPOL31genetic
27708008
POB3_YEASTPOB3genetic
27708008
MOT1_YEASTMOT1genetic
27708008
PSB5_YEASTPRE2genetic
27708008
SEC23_YEASTSEC23genetic
27708008
H4_YEASTHHF1genetic
27708008
ODPB_YEASTPDB1genetic
27708008
RL13A_YEASTRPL13Agenetic
27708008
AIM7_YEASTAIM7genetic
27708008
PSP1_YEASTPSP1genetic
27708008
FDC1_YEASTFDC1genetic
27708008
SLX8_YEASTSLX8genetic
27708008
SDS23_YEASTSDS23genetic
27708008
MED5_YEASTNUT1genetic
27708008
ATG1_YEASTATG1genetic
27708008
YG2W_YEASTYGR111Wgenetic
27708008
YG3L_YEASTYGR149Wgenetic
27708008
RRM3_YEASTRRM3genetic
27708008
HTD2_YEASTHTD2genetic
27708008
RPN10_YEASTRPN10genetic
27708008
CSK21_YEASTCKA1genetic
27708008
FLX1_YEASTFLX1genetic
27708008
YIV5_YEASTYIR035Cgenetic
27708008
SNX4_YEASTSNX4genetic
27708008
RL17B_YEASTRPL17Bgenetic
27708008
IME1_YEASTIME1genetic
27708008
ALAM_YEASTALT1genetic
27708008
HFA1_YEASTHFA1genetic
27708008
HRB1_YEASTHRB1genetic
27708008
EOS1_YEASTEOS1genetic
27708008
COQ2_YEASTCOQ2genetic
27708008
HMI1_YEASTHMI1genetic
27708008
RTC1_YEASTRTC1genetic
27708008
VAM10_YEASTVAM10genetic
27708008
IDH2_YEASTIDH2genetic
27708008
ATG40_YEASTYOR152Cgenetic
27708008
DGAT2_YEASTDGA1genetic
27708008
MNE1_YEASTMNE1genetic
27708008
PMA2_YEASTPMA2genetic
27708008
LGE1_YEASTLGE1genetic
27708008
BECN1_YEASTVPS30genetic
27708008
THP3_YEASTTHP3genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of UBC12_YEAST

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Related Literatures of Post-Translational Modification
Acetylation
ReferencePubMed
"N-terminal acetylation acts as an avidity enhancer within aninterconnected multiprotein complex.";
Scott D.C., Monda J.K., Bennett E.J., Harper J.W., Schulman B.A.;
Science 334:674-678(2011).
Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 2-24 IN COMPLEX WITH DCN1,AND ACETYLATION AT MET-1.

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