IKS1_YEAST - dbPTM
IKS1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID IKS1_YEAST
UniProt AC P47042
Protein Name Probable serine/threonine-protein kinase IKS1
Gene Name IKS1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 667
Subcellular Localization
Protein Description
Protein Sequence MSLVPYEEGSLILDDPNSKSVVVVNPTSGTLSFFQQDNSNNDSELNEDQTASLSALDFPSGIHQYKSPIASYVCPQCGTEINPDIINRRQLHRRASAGVESESSRLSIPENTVPLGFEFANSSFSRRYFQSLERNHRHYALQNDSNNKQGQFSKNKYFIPDDLFIPGYFRKFFKILSLLGNGARGSVYKVVHTIGNTELGVFALKKIPIGNDMEWFNKCIREVKALSSLTHKSANLITYNHVWLEMDSSVGFVRSIDGSQSDSQEEVPCIFILQQYCSGGNLEDCILRKVFNRFSDTESPEERKKKFRTRKKNHGKSGEVGLSTEQLVSIIRDIARGLHELHSIGLIHRDLKPSNCLLLTPFKSDNENDNVYDREHNSDEFFPSIVIGDLGESQLEGESRLGTGCTGTLEFTAPDLIIQGRPVSSSTLPSRSSHTYNEYTFASDMYSLGMICYFIVFGELPFEPQLDIVDLKVRIKNFRFDTEGMIEKHQAMKLKPIDRRIFHLMDALLQPNNDARPTAKTVEETLDEMLINSKPGKKFWKENVDSTLNFSTISEVNENTNSFTDDYIDGDNVTLSLPAPEENLSTVSTQNLQKYSALNRTIQVCYKLVSMILTIIIFKCTKTGSWLSYMSLILLGMVFKSPADERGKHARALVLLAFIAACKKYIY
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Phosphorylation------MSLVPYEEG
------CCCCCCCCC		37.7730377154
10PhosphorylationLVPYEEGSLILDDPN
CCCCCCCCEEECCCC		18.6030377154
96PhosphorylationRQLHRRASAGVESES
HHHHHHHHCCCCCCC		24.6025533186
101PhosphorylationRASAGVESESSRLSI
HHHCCCCCCCCCCCC		40.1322890988
123PhosphorylationGFEFANSSFSRRYFQ
CCEECCCHHHHHHHH		27.3530377154
125PhosphorylationEFANSSFSRRYFQSL
EECCCHHHHHHHHHH		20.1430377154
295PhosphorylationRKVFNRFSDTESPEE
HHHHHHCCCCCCHHH		40.1529136822
297PhosphorylationVFNRFSDTESPEERK
HHHHCCCCCCHHHHH		36.8427717283
299PhosphorylationNRFSDTESPEERKKK
HHCCCCCCHHHHHHH		39.4421440633
403PhosphorylationEGESRLGTGCTGTLE
CCCCCCCCCCCCEEE		33.4023607784
406PhosphorylationSRLGTGCTGTLEFTA
CCCCCCCCCEEEEEC		34.2525752575
408PhosphorylationLGTGCTGTLEFTAPD
CCCCCCCEEEEECCC		12.6430377154
424PhosphorylationIIQGRPVSSSTLPSR
EEECEECCCCCCCCC		22.6630377154
425PhosphorylationIQGRPVSSSTLPSRS
EECEECCCCCCCCCC		27.8130377154
525PhosphorylationTAKTVEETLDEMLIN
CCHHHHHHHHHHHHC		26.4627017623
533PhosphorylationLDEMLINSKPGKKFW
HHHHHHCCCCCCCHH		32.9827017623
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of IKS1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of IKS1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of IKS1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
ADY1_YEASTPFS1physical
16319894
AVO1_YEASTAVO1physical
16319894
SYSC_YEASTSES1physical
16319894
CDC15_YEASTCDC15physical
16319894
SYEC_YEASTGUS1physical
16319894
MTW1_YEASTMTW1physical
16319894
TRM13_YEASTTRM13physical
16319894
GPT1_YEASTSCT1physical
16319894
CWP2_YEASTCWP2physical
16319894
YP013_YEASTCMR3physical
16319894
RL6A_YEASTRPL6Aphysical
16319894
GTR1_YEASTGTR1physical
16319894
NUP53_YEASTNUP53physical
11283351
BCK1_YEASTBCK1genetic
19269370
DBP2_YEASTDBP2physical
20489023
DSK2_YEASTDSK2physical
20489023
EBS1_YEASTEBS1physical
20489023
HRP1_YEASTHRP1physical
20489023
NAB6_YEASTNAB6physical
20489023
PBP4_YEASTPBP4physical
20489023
SIS1_YEASTSIS1physical
20489023
YG5B_YEASTYGR250Cphysical
20489023
SYA_YEASTALA1physical
21460040
CDC11_YEASTCDC11physical
21460040
CLC1_YEASTCLC1physical
21460040
CYP7_YEASTCPR7physical
21460040
CSN9_YEASTCSN9physical
21460040
DON1_YEASTDON1physical
21460040
EKI1_YEASTEKI1physical
21460040
GYL1_YEASTGYL1physical
21460040
IMH1_YEASTIMH1physical
21460040
MASY_YEASTMLS1physical
21460040
NCB2_YEASTNCB2physical
21460040
NKP1_YEASTNKP1physical
21460040
NKP2_YEASTNKP2physical
21460040
NSL1_YEASTNSL1physical
21460040
NUP49_YEASTNUP49physical
21460040
MED10_YEASTNUT2physical
21460040
PEX19_YEASTPEX19physical
21460040
UAP1_YEASTQRI1physical
21460040
RIR4_YEASTRNR4physical
21460040
RPAC2_YEASTRPC19physical
21460040
RPN2_YEASTRPN2physical
21460040
RLA4_YEASTRPP2Bphysical
21460040
RTR1_YEASTRTR1physical
21460040
SHE2_YEASTSHE2physical
21460040
MED21_YEASTSRB7physical
21460040
STI1_YEASTSTI1physical
21460040
ACL4_YEASTYDR161Wphysical
21460040
TOM70_YEASTTOM70physical
21460040
2AAA_YEASTTPD3physical
21460040
VTA1_YEASTVTA1physical
21460040
TAL2_YEASTNQM1physical
21460040
FHP_YEASTYHB1physical
21460040
YH11A_YEASTYHR214C-Cphysical
21460040
MPS3_YEASTMPS3physical
21460040
DOHH_YEASTLIA1physical
21460040
YL287_YEASTYLR287Cphysical
21460040
YM11A_YEASTYML045W-Aphysical
21460040
YRR1_YEASTYRR1physical
21460040
BUB1_YEASTBUB1genetic
21127252
MET18_YEASTMET18genetic
21127252
SYIC_YEASTILS1genetic
27708008
PRP6_YEASTPRP6genetic
27708008
PSB3_YEASTPUP3genetic
27708008
SMD1_YEASTSMD1genetic
27708008
KOG1_YEASTKOG1genetic
27708008
ATC7_YEASTNEO1genetic
27708008
MOB1_YEASTMOB1genetic
27708008
MCM10_YEASTMCM10genetic
27708008
PRP19_YEASTPRP19genetic
27708008
STT4_YEASTSTT4genetic
27708008
CBF3B_YEASTCEP3genetic
27708008
DIB1_YEASTDIB1genetic
27708008
MED10_YEASTNUT2genetic
27708008
NHP10_YEASTNHP10genetic
27708008
MAF1_YEASTMAF1genetic
27708008
VPS41_YEASTVPS41genetic
27708008
RM01_YEASTMRPL1genetic
27708008
PALF_YEASTRIM8genetic
27708008
ASK10_YEASTASK10genetic
27708008
MED20_YEASTSRB2genetic
27708008
PTH_YEASTPTH1genetic
27708008
DAL81_YEASTDAL81genetic
27708008
RL14A_YEASTRPL14Agenetic
27708008
MYO3_YEASTMYO3genetic
27708008
SHE2_YEASTSHE2genetic
27708008
COXM1_YEASTCMC1genetic
27708008
YKR18_YEASTYKR018Cgenetic
27708008
IRS4_YEASTIRS4genetic
27708008
SET3_YEASTSET3genetic
27708008
DNM1_YEASTDNM1genetic
27708008
PSR1_YEASTPSR1genetic
27708008
MLH2_YEASTMLH2genetic
27708008
MMR1_YEASTMMR1genetic
27708008
ATP10_YEASTATP10genetic
27708008
SST2_YEASTSST2genetic
27708008
ATP18_YEASTATP18genetic
27708008
MSC1_YEASTMSC1genetic
27708008
MAC1_YEASTMAC1genetic
27708008
YM30_YEASTYMR155Wgenetic
27708008
PFKA2_YEASTPFK2genetic
27708008
SKY1_YEASTSKY1genetic
27708008
ODP2_YEASTLAT1genetic
27708008
MKS1_YEASTMKS1genetic
27708008
SWS2_YEASTSWS2genetic
27708008
BRE5_YEASTBRE5genetic
27708008
SIN3_YEASTSIN3genetic
27708008
YPQ1_YEASTYPQ1genetic
27708008
PALA_YEASTRIM20genetic
27708008
SUR1_YEASTSUR1genetic
27708008
RU2A_YEASTLEA1genetic
27708008
MDL2_YEASTMDL2genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of IKS1_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-96; THR-403 AND THR-406,AND MASS SPECTROMETRY.
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-96, AND MASSSPECTROMETRY.

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