MGLL_YEAST - dbPTM
MGLL_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID MGLL_YEAST
UniProt AC P28321
Protein Name Monoglyceride lipase {ECO:0000305}
Gene Name YJU3
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 313
Subcellular Localization Cytoplasm. Endoplasmic reticulum. Lipid droplet. Mitochondrion outer membrane. Although the protein was identified in the cytoplasm, several membrane systems and lipid droplets, MGL activity was only measured in membrane fractions and lipid droplets.
Protein Description Converts monoacylglycerides (MAG) to free fatty acids and glycerol. Required for efficient degradation of MAG, short-lived intermediates of glycerolipid metabolism which may also function as lipid signaling molecules. Controls inactivation of the signaling lipid N-palmitoylethanolamine (PEA)..
Protein Sequence MAPYPYKVQTTVPELQYENFDGAKFGYMFWPVQNGTNEVRGRVLLIHGFGEYTKIQFRLMDHLSLNGYESFTFDQRGAGVTSPGRSKGVTDEYHVFNDLEHFVEKNLSECKAKGIPLFMWGHSMGGGICLNYACQGKHKNEISGYIGSGPLIILHPHTMYNKPTQIIAPLLAKFLPRVRIDTGLDLKGITSDKAYRAFLGSDPMSVPLYGSFRQIHDFMQRGAKLYKNENNYIQKNFAKDKPVIIMHGQDDTINDPKGSEKFIQDCPSADKELKLYPGARHSIFSLETDKVFNTVFNDMKQWLDKHTTTEAKP
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
7Ubiquitination-MAPYPYKVQTTVPE
-CCCCCCEEECCCCC		24.3024961812
187AcetylationIDTGLDLKGITSDKA
ECCCCCCCCCCCCHH		48.1924489116
193AcetylationLKGITSDKAYRAFLG
CCCCCCCHHHHHHHC		47.2725381059
235AcetylationNENNYIQKNFAKDKP
CCCCHHCHHCCCCCC		44.4624489116
241UbiquitinationQKNFAKDKPVIIMHG
CHHCCCCCCEEEEEC		40.2423749301
312UbiquitinationKHTTTEAKP------
HCCCCCCCC------		45.0623749301
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of MGLL_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of MGLL_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of MGLL_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
YKG3_YEASTYKL063Cgenetic
16269340
DGK1_YEASTDGK1genetic
16269340
TMS1_YEASTTMS1genetic
20093466
MNN10_YEASTMNN10genetic
20093466
RV167_YEASTRVS167genetic
20093466
YJ24_YEASTKCH1genetic
20093466
BRE2_YEASTBRE2genetic
20093466
EST1_YEASTEST1genetic
20093466
SHE4_YEASTSHE4genetic
20093466
DGK1_YEASTDGK1genetic
20093466
MGLL_MOUSEMgllgenetic
20554061
DGAT2_YEASTDGA1genetic
20554061
PDAT_YEASTLRO1genetic
20554061
ROG1_YEASTROG1genetic
25433290
MGLL_YEASTYJU3physical
26869448
REI1_YEASTREI1genetic
27708008
RV161_YEASTRVS161genetic
27708008
SGF73_YEASTSGF73genetic
27708008
AAKG_YEASTSNF4genetic
27708008
ASF1_YEASTASF1genetic
27708008
SST2_YEASTSST2genetic
27708008
RS7B_YEASTRPS7Bgenetic
27708008
VAM3_YEASTVAM3genetic
27708008
PMA2_YEASTPMA2genetic
27708008
TBP6_YEASTYTA6genetic
27708008
BECN1_YEASTVPS30genetic
27708008
ATG13_YEASTATG13genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of MGLL_YEAST

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Related Literatures of Post-Translational Modification

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