dbPTM

MGLL_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	MGLL_MOUSE
UniProt AC	O35678
Protein Name	Monoglyceride lipase {ECO:0000312\|MGI:MGI:1346042}
Gene Name	Mgll {ECO:0000312\|MGI:MGI:1346042}
Organism	Mus musculus (Mouse).
Sequence Length	303
Subcellular Localization	Cytoplasm, cytosol . Membrane Peripheral membrane protein .
Protein Description	Converts monoacylglycerides to free fatty acids and glycerol. Hydrolyzes the endocannabinoid 2-arachidonoylglycerol, and thereby contributes to the regulation of endocannabinoid signaling, nociperception and perception of pain. [PubMed: 9341166]
Protein Sequence	MPEASSPRRTPQNVPYQDLPHLVNADGQYLFCRYWKPSGTPKALIFVSHGAGEHCGRYDELAHMLKGLDMLVFAHDHVGHGQSEGERMVVSDFQVFVRDVLQHVDTIQKDYPDVPIFLLGHSMGGAISILVAAERPTYFSGMVLISPLVLANPESASTLKVLAAKLLNFVLPNMTLGRIDSSVLSRNKSEVDLYNSDPLVCRAGLKVCFGIQLLNAVARVERAMPRLTLPFLLLQGSADRLCDSKGAYLLMESSRSQDKTLKMYEGAYHVLHRELPEVTNSVLHEVNSWVSHRIAAAGAGCPP

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MPEASSPRRTPQ ---CCCCCCCCCCCC	38.93	29899451
6	Phosphorylation	--MPEASSPRRTPQN --CCCCCCCCCCCCC	29.49	29899451
10	Phosphorylation	EASSPRRTPQNVPYQ CCCCCCCCCCCCCHH	30.42	19060867
32	S-nitrosocysteine	ADGQYLFCRYWKPSG CCCCEEEEEEECCCC	2.77	-
32	S-palmitoylation	ADGQYLFCRYWKPSG CCCCEEEEEEECCCC	2.77	28526873
32	S-nitrosylation	ADGQYLFCRYWKPSG CCCCEEEEEEECCCC	2.77	21278135
36	Ubiquitination	YLFCRYWKPSGTPKA EEEEEEECCCCCCCE	21.99	-
38	Phosphorylation	FCRYWKPSGTPKALI EEEEECCCCCCCEEE	52.12	-
40	Phosphorylation	RYWKPSGTPKALIFV EEECCCCCCCEEEEE	26.42	21183079
48	Phosphorylation	PKALIFVSHGAGEHC CCEEEEEECCCHHCC	12.88	-
54	Phosphorylation	VSHGAGEHCGRYDEL EECCCHHCCCCHHHH	20.58	24719451
55	S-palmitoylation	SHGAGEHCGRYDELA ECCCHHCCCCHHHHH	2.63	28526873
56	Phosphorylation	HGAGEHCGRYDELAH CCCHHCCCCHHHHHH	32.84	24719451
58	Nitration	AGEHCGRYDELAHML CHHCCCCHHHHHHHH	10.07	16800626
58	Nitration	AGEHCGRYDELAHML CHHCCCCHHHHHHHH	10.07	16800626
58	Nitrated tyrosine	AGEHCGRYDELAHML CHHCCCCHHHHHHHH	10.07	-
64	Phosphorylation	RYDELAHMLKGLDML CHHHHHHHHHCCCEE	3.26	24719451
137	Phosphorylation	LVAAERPTYFSGMVL HHHCCCCCCCCCCEE	43.34	25777480
138	Phosphorylation	VAAERPTYFSGMVLI HHCCCCCCCCCCEEE	9.83	25777480
140	Phosphorylation	AERPTYFSGMVLISP CCCCCCCCCCEEECC	18.63	25777480
146	Phosphorylation	FSGMVLISPLVLANP CCCCEEECCHHHCCC	14.18	25777480
155	Phosphorylation	LVLANPESASTLKVL HHHCCCCCHHHHHHH	28.86	25777480
157	Phosphorylation	LANPESASTLKVLAA HCCCCCHHHHHHHHH	43.48	25777480
158	Phosphorylation	ANPESASTLKVLAAK CCCCCHHHHHHHHHH	30.25	25777480
182	Phosphorylation	TLGRIDSSVLSRNKS CCCCCCHHHHCCCHH	24.27	-
188	Ubiquitination	SSVLSRNKSEVDLYN HHHHCCCHHHHCCCC	47.05	-
189	Phosphorylation	SVLSRNKSEVDLYNS HHHCCCHHHHCCCCC	46.53	25521595
194	Phosphorylation	NKSEVDLYNSDPLVC CHHHHCCCCCCCCHH	14.25	29472430
196	Phosphorylation	SEVDLYNSDPLVCRA HHHCCCCCCCCHHHH	27.35	19367708
201	S-palmitoylation	YNSDPLVCRAGLKVC CCCCCCHHHHCHHHH	3.04	28526873
205	Phosphorylation	PLVCRAGLKVCFGIQ CCHHHHCHHHHHHHH	3.52	24719451
208	S-palmitoylation	CRAGLKVCFGIQLLN HHHCHHHHHHHHHHH	2.18	28526873
228	Phosphorylation	ERAMPRLTLPFLLLQ HHHCHHCCHHHHHHH	33.39	27180971
245	Ubiquitination	ADRLCDSKGAYLLME HHHHHCCCCCEEEEE	34.02	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of MGLL_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of MGLL_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of MGLL_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of MGLL_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of MGLL_MOUSE

Related Literatures of Post-Translational Modification

Nitration
Reference	PubMed
"Endogenously nitrated proteins in mouse brain: links toneurodegenerative disease."; Sacksteder C.A., Qian W.-J., Knyushko T.V., Wang H., Chin M.H.,Lacan G., Melega W.P., Camp D.G. II, Smith R.D., Smith D.J.,Squier T.C., Bigelow D.J.; Biochemistry 45:8009-8022(2006). Cited for: NITRATION [LARGE SCALE ANALYSIS] AT TYR-58, AND MASS SPECTROMETRY.	16800626 [Abstract]
Phosphorylation
Reference	PubMed
"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry."; Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.; J. Proteome Res. 7:5314-5326(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-189, AND MASSSPECTROMETRY.	19367708 [Abstract]