ALR1_YEAST - dbPTM
ALR1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ALR1_YEAST
UniProt AC Q08269
Protein Name Magnesium transporter ALR1
Gene Name ALR1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 859
Subcellular Localization Cell membrane
Multi-pass membrane protein .
Protein Description Plasma membrane magnesium transporter..
Protein Sequence MSSSSSSSESSPNLSRSNSLANTMVSMKTEDHTGLYDHRQHPDSLPVRHQPPTLKNKEIAKSTKPSIPKEQKSATRYNSHVDVGSVPSRGRMDFEDEGQGMDETVAHHQLRASAILTSNARPSRLAHSMPHQRQLYVESNIHTPPKDVGVKRDYTMSSSTASSGNKSKLSASSSASPITKVRKSSLVSPVLEIPHESKSDTHSKLAKPKKRTYSTTSAHSSINPAVLLTKSTSQKSDADDDTLERKPVRMNTRASFDSDVSQASRDSQETEEDVCFPMPPQLHTRVNGIDFDELEEYAQFANAEKSQFLASLQVPNEQKYSNVSQDIGFTSSTSTSGSSAALKYTPRVSQTGEKSESTNETEIHEKKEDEHEKIKPSLHPGISFGKNKVEGEENENIPSNDPAYCSYQGTDFQIPNRFSFFCSESDETVHASDIPSLVSEGQTFYELFRGGEPTWWLDCSCPTDDEMRCIAKAFGIHPLTAEDIRMQETREKVELFKSYYFVCFHTFENDKESEDFLEPINVYIVVCRSGVLTFHFGPISHCANVRRRVRQLRDYVNVNSDWLCYALIDDITDSFAPVIQSIEYEADAIEDSVFMARDMDFAAMLQRIGESRRKTMTLMRLLSGKADVIKMFAKRCQDEANGIGPALTSQINIANLQARQDNASHIKNNSSTTVPNNYAPTTSQPRGDIALYLGDIQDHLLTMFQNLLAYEKIFSRSHTNYLAQLQVESFNSNNKVTEMLGKVTMIGTMLVPLNVITGLFGMNVKVPGENSSIAWWFGILGVLLLLAVLGWFLASYWIKRIDPPATLNEAAESGAKSVISSFLPKRNKRFNDRSKNINVRAGPSNKSVASLPSRYSRYD
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Acetylation------MSSSSSSSE
------CCCCCCCCC		38.6422814378
7Phosphorylation-MSSSSSSSESSPNL
-CCCCCCCCCCCCCC		39.8230377154
11PhosphorylationSSSSSESSPNLSRSN
CCCCCCCCCCCCHHH		17.4730377154
15PhosphorylationSESSPNLSRSNSLAN
CCCCCCCCHHHHHHH		40.0628889911
17PhosphorylationSSPNLSRSNSLANTM
CCCCCCHHHHHHHHH		27.6522369663
19PhosphorylationPNLSRSNSLANTMVS
CCCCHHHHHHHHHHE		30.0622369663
23PhosphorylationRSNSLANTMVSMKTE
HHHHHHHHHHEECCC		17.2222369663
26PhosphorylationSLANTMVSMKTEDHT
HHHHHHHEECCCCCC		12.0722369663
29PhosphorylationNTMVSMKTEDHTGLY
HHHHEECCCCCCCCC		37.6919779198
77PhosphorylationEQKSATRYNSHVDVG
HHHCCCCCCCCCCCC		19.3617330950
79PhosphorylationKSATRYNSHVDVGSV
HCCCCCCCCCCCCCC		18.8923749301
85PhosphorylationNSHVDVGSVPSRGRM
CCCCCCCCCCCCCCC		30.6123749301
88PhosphorylationVDVGSVPSRGRMDFE
CCCCCCCCCCCCCCC		45.2528889911
139PhosphorylationQRQLYVESNIHTPPK
CCEEEEECCCCCCCC		30.9219779198
143PhosphorylationYVESNIHTPPKDVGV
EEECCCCCCCCCCCC		37.1723749301
157PhosphorylationVKRDYTMSSSTASSG
CCCEEECCCCCCCCC		17.2121440633
159PhosphorylationRDYTMSSSTASSGNK
CEEECCCCCCCCCCC		22.2327017623
160PhosphorylationDYTMSSSTASSGNKS
EEECCCCCCCCCCCC		32.2929688323
162PhosphorylationTMSSSTASSGNKSKL
ECCCCCCCCCCCCCC		38.5821440633
163PhosphorylationMSSSTASSGNKSKLS
CCCCCCCCCCCCCCC		43.8721440633
170PhosphorylationSGNKSKLSASSSASP
CCCCCCCCCCCCCCC		29.8221440633
172PhosphorylationNKSKLSASSSASPIT
CCCCCCCCCCCCCCC		22.8120377248
173PhosphorylationKSKLSASSSASPITK
CCCCCCCCCCCCCCH		29.6421440633
174PhosphorylationSKLSASSSASPITKV
CCCCCCCCCCCCCHH		30.2120377248
176PhosphorylationLSASSSASPITKVRK
CCCCCCCCCCCHHCH		20.8421551504
179PhosphorylationSSSASPITKVRKSSL
CCCCCCCCHHCHHHC		27.2019684113
184PhosphorylationPITKVRKSSLVSPVL
CCCHHCHHHCCCCEE		20.5217330950
185PhosphorylationITKVRKSSLVSPVLE
CCHHCHHHCCCCEEE		35.5117330950
188PhosphorylationVRKSSLVSPVLEIPH
HCHHHCCCCEEECCC		18.0019823750
197PhosphorylationVLEIPHESKSDTHSK
EEECCCCCCCCCCCC		34.1321440633
199PhosphorylationEIPHESKSDTHSKLA
ECCCCCCCCCCCCCC		57.9521440633
203PhosphorylationESKSDTHSKLAKPKK
CCCCCCCCCCCCCCC		31.3023749301
212PhosphorylationLAKPKKRTYSTTSAH
CCCCCCCCCCCCCCC		30.6119823750
213PhosphorylationAKPKKRTYSTTSAHS
CCCCCCCCCCCCCCC		14.1919823750
214PhosphorylationKPKKRTYSTTSAHSS
CCCCCCCCCCCCCCC		25.2917330950
215PhosphorylationPKKRTYSTTSAHSSI
CCCCCCCCCCCCCCC		17.8517330950
216PhosphorylationKKRTYSTTSAHSSIN
CCCCCCCCCCCCCCC		20.2717330950
217PhosphorylationKRTYSTTSAHSSINP
CCCCCCCCCCCCCCC		24.8717330950
220PhosphorylationYSTTSAHSSINPAVL
CCCCCCCCCCCCEEE		32.4117330950
221PhosphorylationSTTSAHSSINPAVLL
CCCCCCCCCCCEEEE		19.2717330950
229PhosphorylationINPAVLLTKSTSQKS
CCCEEEEECCCCCCC		20.8419823750
231PhosphorylationPAVLLTKSTSQKSDA
CEEEEECCCCCCCCC		28.2322890988
232PhosphorylationAVLLTKSTSQKSDAD
EEEEECCCCCCCCCC		36.4122890988
233PhosphorylationVLLTKSTSQKSDADD
EEEECCCCCCCCCCC		42.5817330950
235UbiquitinationLTKSTSQKSDADDDT
EECCCCCCCCCCCCC		50.5023749301
236PhosphorylationTKSTSQKSDADDDTL
ECCCCCCCCCCCCCC		30.3217330950
242PhosphorylationKSDADDDTLERKPVR
CCCCCCCCCCCCCCC		37.2017330950
255PhosphorylationVRMNTRASFDSDVSQ
CCCCCCHHCCCCCHH		26.7128889911
258PhosphorylationNTRASFDSDVSQASR
CCCHHCCCCCHHHCC		37.5928889911
311PhosphorylationEKSQFLASLQVPNEQ
HHHHHHHHCCCCCCH		22.8328152593
339PhosphorylationSTSTSGSSAALKYTP
CCCCCCCCEECEECC		22.5323749301
349PhosphorylationLKYTPRVSQTGEKSE
CEECCCCCCCCCCCC		24.2521440633
351PhosphorylationYTPRVSQTGEKSEST
ECCCCCCCCCCCCCC		39.5419795423
354UbiquitinationRVSQTGEKSESTNET
CCCCCCCCCCCCCCC		61.9523749301
355PhosphorylationVSQTGEKSESTNETE
CCCCCCCCCCCCCCC		32.2622890988
357PhosphorylationQTGEKSESTNETEIH
CCCCCCCCCCCCCCC		43.5625521595
358PhosphorylationTGEKSESTNETEIHE
CCCCCCCCCCCCCCC		32.7822890988
361PhosphorylationKSESTNETEIHEKKE
CCCCCCCCCCCCCHH		42.1622890988
377PhosphorylationEHEKIKPSLHPGISF
HHHCCCCCCCCCCCC		34.0219779198
383PhosphorylationPSLHPGISFGKNKVE
CCCCCCCCCCCCCCC		33.5821440633
406PhosphorylationSNDPAYCSYQGTDFQ
CCCCCCCCCCCCCCC		14.0719779198
410PhosphorylationAYCSYQGTDFQIPNR
CCCCCCCCCCCCCCC		20.3619779198
648PhosphorylationNGIGPALTSQINIAN
CCCCHHHHHHHHHHH		22.2322369663
649PhosphorylationGIGPALTSQINIANL
CCCHHHHHHHHHHHH		29.8822369663
667UbiquitinationQDNASHIKNNSSTTV
HHCHHHCCCCCCCCC		44.6523749301
670PhosphorylationASHIKNNSSTTVPNN
HHHCCCCCCCCCCCC		38.1523749301
817PhosphorylationAAESGAKSVISSFLP
HHHHHCHHHHHHHCC		24.9322890988
820PhosphorylationSGAKSVISSFLPKRN
HHCHHHHHHHCCCCC		16.9422890988
821PhosphorylationGAKSVISSFLPKRNK
HCHHHHHHHCCCCCC		21.4822890988
844PhosphorylationINVRAGPSNKSVASL
CEECCCCCCCCHHCC		56.8427717283
846UbiquitinationVRAGPSNKSVASLPS
ECCCCCCCCHHCCCC		51.1223749301
847PhosphorylationRAGPSNKSVASLPSR
CCCCCCCCHHCCCCC		27.4522369663
850PhosphorylationPSNKSVASLPSRYSR
CCCCCHHCCCCCCCC		38.3622369663
853PhosphorylationKSVASLPSRYSRYD-
CCHHCCCCCCCCCC-		49.4922369663
855PhosphorylationVASLPSRYSRYD---
HHCCCCCCCCCC---		11.2224961812
856PhosphorylationASLPSRYSRYD----
HCCCCCCCCCC----		24.2128152593
858PhosphorylationLPSRYSRYD------
CCCCCCCCC------		21.7719823750
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
-KUbiquitinationE3 ubiquitin ligaseRSP5P39940
PMID:22199232
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ALR1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ALR1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
EI2BB_YEASTGCD7physical
10688190
MED3_YEASTPGD1physical
10688190
SNAPN_YEASTSNN1physical
10688190
ALR1_YEASTALR1physical
16903865
ALR2_YEASTALR2physical
16903865
ALR2_YEASTALR2genetic
17926032
ALR2_YEASTALR2genetic
19720860
CALX_YEASTCNE1genetic
20093466
NRG2_YEASTNRG2genetic
20093466
MCFS2_YEASTEHT1genetic
20093466
RV167_YEASTRVS167genetic
20093466
COPE_YEASTSEC28genetic
20093466
YJ24_YEASTKCH1genetic
20093466
PLMT_YEASTOPI3genetic
20093466
SIC1_YEASTSIC1genetic
20093466
YMD8_YEASTYMD8genetic
20093466
HSC82_YEASTHSC82genetic
20093466
SNAPN_YEASTSNN1genetic
20093466
SWS2_YEASTSWS2genetic
20093466
YIG1_YEASTYIG1genetic
20093466
COX10_YEASTCOX10genetic
20093466
MNR2_YEASTMNR2genetic
21738593
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ALR1_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-17; SER-19; SER-184;THR-232; SER-233; SER-236; SER-357 AND SER-850, AND MASS SPECTROMETRY.
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-233; SER-236 ANDTHR-242, AND MASS SPECTROMETRY.
"Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae.";
Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.;
J. Proteome Res. 6:1190-1197(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-77; SER-220; SER-221;SER-236 AND THR-242, AND MASS SPECTROMETRY.
"A proteomics approach to understanding protein ubiquitination.";
Peng J., Schwartz D., Elias J.E., Thoreen C.C., Cheng D.,Marsischky G., Roelofs J., Finley D., Gygi S.P.;
Nat. Biotechnol. 21:921-926(2003).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-188, AND MASSSPECTROMETRY.

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