ALR2_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ALR2_YEAST
• UniProt AC: P43553
• Protein Name: Magnesium transporter ALR2
• Gene Name: ALR2
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 858
• Subcellular Localization: Cell membrane ; Multi-pass membrane protein .
• Protein Description: Plasma membrane magnesium transporter..
• Protein Sequence: MSSLSTSFDSSSDLPRSKSVDNTAASMKTGKYPKLENYRQYSDAQPIRHEALALKVDETKDSRHKFSSSNGENSGVENGGYVEKTNISTSGRMDFEGEAEAEAVKRYQLRSFALLSSNARPSRLAKSETHQKQIHVESIAPSLPKNAALERGHDTALPAGTSSNRCNLEASSSARTFTSARKASLVSAIFETSAESEHGTHPKQAKLKRRTYSTISTHSSVNPTTLLTRTASQKSDMGNDTRRIKPLRMDSRVSFHSEISQASRDSQETEEDVCFPMFRLLHTRVNGVDFDELEEYAQISNAERNLSLANHQRHSERTYNHTDQDTGFTNSASTSGSSAALKYTPEISRTLEKNCSVNEMYVSENNESVREDDKPDLHPDVTFGRNKIEGEKEGNDSSYSRAYYTLQNTEYQIPSRFSFFRSESDETVHASDIPSLISEGQTFYELFKGGDPTWWLDCSCPTDDEMRCIAKTFGIHPLTAEDIRMQETREKVELFKSYYFVCFHTFENDKESENYLEPINVYIVVFRSGVLTFHFDPISHCANVRRRVRQLRDYVSVNSDWLCYALIDDITDSFAPVIQSIEYEADSIDDSVFMTRDMDFAAMLQRIGESRRKTMTLMRLLSGKADVIKMFAKRCQDETNGIGPVLKSQTNMVNLQAEQENVNQNNSNNQISLSNSYMQTTSQPRGDIALYLGDIQDHLLTMFQNLLAYEKIFSRSHANYLAQLQVESFNSNNKVTEMLGKVTMLGTMLVPLNVITGLFGMNVKVPGRNGSIAWWYGILGVLLLLAVISWFLASYWIKKIDPPATLNEAAGSGAKSVISSFLPKRDKRFNDDSKNGNARVGVRRKSTVSLPSRYSRYN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
163	Phosphorylation	ALPAGTSSNRCNLEA CCCCCCCCCCCCCCC	28.29	30377154
184	Phosphorylation	FTSARKASLVSAIFE HHHHHHHHHHHHHHH	32.13	21082442
187	Phosphorylation	ARKASLVSAIFETSA HHHHHHHHHHHHCCC	22.42	28889911
193	Phosphorylation	VSAIFETSAESEHGT HHHHHHCCCCCCCCC	23.88	21082442
200	Phosphorylation	SAESEHGTHPKQAKL CCCCCCCCCHHHHHC	36.59	21082442
241	Phosphorylation	KSDMGNDTRRIKPLR CCCCCCCCCCCCCCC	26.33	27017623
251	Phosphorylation	IKPLRMDSRVSFHSE CCCCCCCCCCCCHHH	25.82	27017623
348	Phosphorylation	LKYTPEISRTLEKNC HHCCHHHHHHHHHCC	19.97	30377154
453	Phosphorylation	LFKGGDPTWWLDCSC HHCCCCCCEEEECCC	33.73	27017623
459	Phosphorylation	PTWWLDCSCPTDDEM CCEEEECCCCCCHHH	23.85	27017623
462	Phosphorylation	WLDCSCPTDDEMRCI EEECCCCCCHHHHHH	61.48	27017623
816	Phosphorylation	AAGSGAKSVISSFLP HCCCCHHHHHHHHCC	24.93	22890988
819	Phosphorylation	SGAKSVISSFLPKRD CCHHHHHHHHCCCCC	16.94	22890988
820	Phosphorylation	GAKSVISSFLPKRDK CHHHHHHHHCCCCCC	21.48	22890988
846	Phosphorylation	RVGVRRKSTVSLPSR CCCCCCCCEECCCCC	32.03	27214570
847	Phosphorylation	VGVRRKSTVSLPSRY CCCCCCCEECCCCCC	19.69	27214570
852	Phosphorylation	KSTVSLPSRYSRYN- CCEECCCCCCCCCC-	49.49	27214570

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ALR2_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ALR2_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ALR2_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ALR1_YEAST	ALR1	physical	16903865
ALR2_YEAST	ALR2	physical	16903865
MID2_YEAST	MID2	genetic	20526336
MNR2_YEAST	MNR2	genetic	21738593
SC61A_YEAST	SEC61	genetic	27708008
NAB3_YEAST	NAB3	genetic	27708008
MED8_YEAST	MED8	genetic	27708008
NOP14_YEAST	NOP14	genetic	27708008
PSF1_YEAST	PSF1	genetic	27708008
SAD1_YEAST	SAD1	genetic	27708008
YIP1_YEAST	YIP1	genetic	27708008
RRP41_YEAST	SKI6	genetic	27708008
ARP4_YEAST	ARP4	genetic	27708008
MCM1_YEAST	MCM1	genetic	27708008
PDS5_YEAST	PDS5	genetic	27708008
OST2_YEAST	OST2	genetic	27708008

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.