HOL1_YEAST - dbPTM
HOL1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID HOL1_YEAST
UniProt AC P53389
Protein Name Protein HOL1
Gene Name HOL1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 586
Subcellular Localization Membrane
Multi-pass membrane protein .
Protein Description Seems to be involved in the uptake of several cations and of histidinol..
Protein Sequence MDKYTNRDHPDYIPGTFNIYSSQNLENGIIYESKLKKTSSGVVLIPQPSYSPNDPLNWSSWRKLAHFGLMAFITAFTAATSNDAGAAQDSLNEIYGISYDSMNTGAGVLFLGIGWSTLFLAPFANLYGRKITYIVCTTLGLFGALWFALAKRTSDTIWSQLFVGISESCAEAQVQLSLSDIFFQHQLGSVLTVYIMCTSIGTFLGPLIAGYISAFTNFRWVGWVAVIISGGLLITIIFGCEETYFDRGQYMTPLTSCQSGYEDGTTLQNSDNTAVSRRKRHLDAKLSTPGAMGEKGVDLSETAEFEVNNEEEVTIPETRELIDGSKEHLKPYPKRVAILTKATNLKGYGFKQYFKYLKINLRMFLFPPVWLSGMFWGIQDVFLTFYLTTQESAYYEPPWNYSDFGVAIMNVPTLIGAVIGCICAGIVSDYFVLWMARHNRGILEAEFRLYFSIATAIIGPAGLLMFGIGTARQWPWQAIYVGLGFVGFAWGCSGDIAMAYLMDCYPDMVLEGMVCTAIINNTISCIFTFTCSDWLAASGTENTYIALAVINFGITAFALPMYYYGKRIRLWTKRWYLQSVNLRDGV
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
252PhosphorylationFDRGQYMTPLTSCQS
CCCCCCCCCCCCCCC		15.3723749301
266PhosphorylationSGYEDGTTLQNSDNT
CCCCCCCEEECCCCC		31.6923749301
270PhosphorylationDGTTLQNSDNTAVSR
CCCEEECCCCCCHHH		21.1928889911
273PhosphorylationTLQNSDNTAVSRRKR
EEECCCCCCHHHHHH		33.1727017623
276PhosphorylationNSDNTAVSRRKRHLD
CCCCCCHHHHHHHHH		24.7328889911
285UbiquitinationRKRHLDAKLSTPGAM
HHHHHHHHCCCCCCC		42.5123749301
287PhosphorylationRHLDAKLSTPGAMGE
HHHHHHCCCCCCCCC		31.6721126336
288PhosphorylationHLDAKLSTPGAMGEK
HHHHHCCCCCCCCCC		35.8625752575
314PhosphorylationVNNEEEVTIPETREL
ECCCCEEECCCHHHH		33.8127214570
326UbiquitinationRELIDGSKEHLKPYP
HHHCCCCHHHCCCCC		55.4722817900
330UbiquitinationDGSKEHLKPYPKRVA
CCCHHHCCCCCCCEE		44.4022817900
330AcetylationDGSKEHLKPYPKRVA
CCCHHHCCCCCCCEE		44.4024489116
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of HOL1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of HOL1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of HOL1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
CSG2_YEASTCSG2genetic
20093466
MRC1_YEASTMRC1genetic
20093466
STE50_YEASTSTE50genetic
20093466
SGF29_YEASTSGF29genetic
20093466
RIM1_YEASTRIM1genetic
20093466
SNT1_YEASTSNT1genetic
20093466
YD180_YEASTYDL180Wgenetic
20093466
NHP10_YEASTNHP10genetic
20093466
RM01_YEASTMRPL1genetic
20093466
VBA4_YEASTVBA4genetic
20093466
EF2_YEASTEFT2genetic
20093466
SPT3_YEASTSPT3genetic
20093466
EMI1_YEASTEMI1genetic
20093466
PP2C2_YEASTPTC2genetic
20093466
SHO1_YEASTSHO1genetic
20093466
PT122_YEASTPET122genetic
20093466
FAR7_YEASTFAR7genetic
20093466
MTO1_YEASTMTO1genetic
20093466
SGF73_YEASTSGF73genetic
20093466
DBF2_YEASTDBF2genetic
20093466
PHB2_YEASTPHB2genetic
20093466
COPE_YEASTSEC28genetic
20093466
FIS1_YEASTFIS1genetic
20093466
MRX5_YEASTYJL147Cgenetic
20093466
PTK2_YEASTPTK2genetic
20093466
DCOR_YEASTSPE1genetic
20093466
HAP4_YEASTHAP4genetic
20093466
CYT2_YEASTCYT2genetic
20093466
RL14A_YEASTRPL14Agenetic
20093466
MEH1_YEASTMEH1genetic
20093466
IMDH4_YEASTIMD4genetic
20093466
AMPD_YEASTAMD1genetic
20093466
PEX12_YEASTPEX12genetic
20093466
PFKA2_YEASTPFK2genetic
20093466
DCAM_YEASTSPE2genetic
20093466
GLO4_YEASTGLO4genetic
20093466
CY1_YEASTCYT1genetic
20093466
COQ7_YEASTCAT5genetic
20093466
MNE1_YEASTMNE1genetic
20093466
NCBP2_YEASTCBC2genetic
20093466
SPEE_YEASTSPE3genetic
20093466
QCR2_YEASTQCR2genetic
20093466
PHO88_YEASTPHO88physical
16093310
OAC1_YEASTOAC1physical
16093310
STE50_YEASTSTE50genetic
27708008
APC11_YEASTAPC11genetic
27708008
SPC19_YEASTSPC19genetic
27708008
GPI8_YEASTGPI8genetic
27708008
GPI12_YEASTGPI12genetic
27708008
HRR25_YEASTHRR25genetic
27708008
SEC23_YEASTSEC23genetic
27708008
ECM8_YEASTECM8genetic
27708008
SGF29_YEASTSGF29genetic
27708008
MGR1_YEASTMGR1genetic
27708008
UME6_YEASTUME6genetic
27708008
PEX5_YEASTPEX5genetic
27708008
PMP3_YEASTPMP3genetic
27708008
OMS1_YEASTOMS1genetic
27708008
EF2_YEASTEFT2genetic
27708008
SNF1_YEASTSNF1genetic
27708008
SHO1_YEASTSHO1genetic
27708008
HAP4_YEASTHAP4genetic
27708008
DCOR_YEASTSPE1genetic
27708008
DCAM_YEASTSPE2genetic
27708008
SPEE_YEASTSPE3genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of HOL1_YEAST

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Related Literatures of Post-Translational Modification

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