PP2C2_YEAST - dbPTM
PP2C2_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PP2C2_YEAST
UniProt AC P39966
Protein Name Protein phosphatase 2C homolog 2
Gene Name PTC2
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 464
Subcellular Localization
Protein Description Responsible, together with PTC3, for the dephosphorylation of the cyclin-dependent protein kinase CDC28..
Protein Sequence MGQILSNPVIDKESHSGADSLTAFGLCAMQGWRMSMEDSHILEPNVLTKSDKDHIAFYGIFDGHGGAKVAEYCGNKIVEILQEQKSFHEGNLPRALIDTFINTDVKLLQDPVMKEDHSGCTATSILVSKSQNLLVCGNAGDSRTVLATDGNAKALSYDHKPTLASEKSRIVAADGFVEMDRVNGNLALSRAIGDFEFKSNPKLGPEEQIVTCVPDILEHSLDYDRDEFVILACDGIWDCLTSQDCVDLVHLGLREGKTLNEISSRIIDVCCAPTTEGTGIGCDNMSIVVVALLKEGEDVAQWSDRMKSKAHRTSVRSFADKRRRVFSYYDFSKCNDEQVFAITTKKPQDKFTRDHEAAVASVTAADNDDPMDIDDTDADTDAENLDPSSQSKSKTSGPIDLASLEALLGATGGVKTDSNGNKVTYTLPQSALAQLLQTMGHDPASSHPENDSNTDHKAGRSHLQ
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
35PhosphorylationAMQGWRMSMEDSHIL
HHHCCCCCCCCCCCC		15.5023749301
52AcetylationNVLTKSDKDHIAFYG
CCCCCCCCCCEEEEE		59.2924489116
52UbiquitinationNVLTKSDKDHIAFYG
CCCCCCCCCCEEEEE		59.2923749301
85AcetylationVEILQEQKSFHEGNL
HHHHHHHHCCCCCCC		55.1024489116
86PhosphorylationEILQEQKSFHEGNLP
HHHHHHHCCCCCCCC		31.3721440633
114UbiquitinationLLQDPVMKEDHSGCT
HHCCCCCCCCCCCCC		61.2923749301
153UbiquitinationLATDGNAKALSYDHK
EEECCCCEECCCCCC		54.5917644757
160UbiquitinationKALSYDHKPTLASEK
EECCCCCCCCCCCCH		36.4817644757
167UbiquitinationKPTLASEKSRIVAAD
CCCCCCCHHHEEEEC		42.4117644757
257UbiquitinationHLGLREGKTLNEISS
HHHCCCCCCHHHHHH		45.1223749301
264PhosphorylationKTLNEISSRIIDVCC
CCHHHHHHHHHEECC		32.9128132839
327PhosphorylationDKRRRVFSYYDFSKC
HHHCCEEEECCHHHC		21.6722369663
350AcetylationTTKKPQDKFTRDHEA
ECCCCCCCCCCCHHH		43.3025381059
376PhosphorylationDPMDIDDTDADTDAE
CCCCCCCCCCCCCHH		29.3721440633
380PhosphorylationIDDTDADTDAENLDP
CCCCCCCCCHHHCCC		38.5421440633
388PhosphorylationDAENLDPSSQSKSKT
CHHHCCCCCCCCCCC		40.4519795423
389PhosphorylationAENLDPSSQSKSKTS
HHHCCCCCCCCCCCC		43.8119795423
391PhosphorylationNLDPSSQSKSKTSGP
HCCCCCCCCCCCCCC		40.6219795423
394UbiquitinationPSSQSKSKTSGPIDL
CCCCCCCCCCCCCCH		50.9024961812
418PhosphorylationTGGVKTDSNGNKVTY
CCCEEECCCCCEEEE		52.4428889911
430PhosphorylationVTYTLPQSALAQLLQ
EEEECCHHHHHHHHH		24.2628889911
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PP2C2_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PP2C2_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PP2C2_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
PAA1_YEASTPAA1physical
10688190
RAD53_YEASTRAD53physical
12667463
HOG1_YEASTHOG1physical
12477803
IRE1_YEASTIRE1physical
9528768
PTP2_YEASTPTP2genetic
12477803
ALDH6_YEASTALD6physical
16429126
SHQ1_YEASTSHQ1physical
16429126
PAA1_YEASTPAA1physical
16429126
WTM1_YEASTWTM1physical
16429126
RAD53_YEASTRAD53physical
17325030
PP4C_YEASTPPH3genetic
17517611
PP4R3_YEASTPSY2genetic
17517611
NUP84_YEASTNUP84genetic
19269370
IPK1_YEASTIPK1genetic
19269370
SEM1_YEASTSEM1genetic
19269370
BOI2_YEASTBOI2genetic
19269370
CSK2B_YEASTCKB1genetic
19269370
GET1_YEASTGET1genetic
19269370
SKI8_YEASTSKI8genetic
19269370
SLX9_YEASTSLX9genetic
19269370
DBF2_YEASTDBF2genetic
19269370
LRP1_YEASTLRP1genetic
19269370
CTK2_YEASTCTK2genetic
19269370
MNN11_YEASTMNN11genetic
19269370
ELM1_YEASTELM1genetic
19269370
CTK1_YEASTCTK1genetic
19269370
SAC1_YEASTSAC1genetic
19269370
IRS4_YEASTIRS4genetic
19269370
RIC1_YEASTRIC1genetic
19269370
SEC22_YEASTSEC22genetic
19269370
PFD5_YEASTGIM5genetic
19269370
ZDS1_YEASTZDS1genetic
19269370
COG6_YEASTCOG6genetic
19269370
COG5_YEASTCOG5genetic
19269370
MSG5_YEASTMSG5genetic
19269370
BRE5_YEASTBRE5genetic
19269370
ELP3_YEASTELP3genetic
19269370
BEM3_YEASTBEM3genetic
19269370
PP4C_YEASTPPH3genetic
18628397
PP2C3_YEASTPTC3genetic
19884341
VPS8_YEASTVPS8genetic
20093466
SLT11_YEASTECM2genetic
20093466
SDS24_YEASTSDS24genetic
20093466
STE50_YEASTSTE50genetic
20093466
ARF1_YEASTARF1genetic
20093466
YD157_YEASTYDL157Cgenetic
20093466
SLX5_YEASTSLX5genetic
20093466
PP2C1_YEASTPTC1genetic
20093466
PP4C_YEASTPPH3genetic
20093466
ACOX_YEASTPOX1genetic
20093466
CGR1_YEASTCGR1genetic
20093466
SNF6_YEASTSNF6genetic
20093466
ICE2_YEASTICE2genetic
20093466
PTK2_YEASTPTK2genetic
20093466
DHOM_YEASTHOM6genetic
20093466
MAOM_YEASTMAE1genetic
20093466
TOF2_YEASTTOF2genetic
20093466
NU133_YEASTNUP133genetic
20093466
FKS1_YEASTFKS1genetic
20093466
NSG2_YEASTNSG2genetic
20093466
CUZ1_YEASTCUZ1genetic
20093466
EAF7_YEASTEAF7genetic
20093466
TOM70_YEASTTOM70genetic
20093466
EOS1_YEASTEOS1genetic
20093466
HOL1_YEASTHOL1genetic
20093466
INO4_YEASTINO4genetic
20093466
PMG3_YEASTGPM3genetic
20093466
DIA2_YEASTDIA2genetic
20093466
VPS21_YEASTVPS21genetic
20093466
PALA_YEASTRIM20genetic
20093466
DGK1_YEASTDGK1genetic
20093466
MNE1_YEASTMNE1genetic
20093466
SET6_YEASTSET6genetic
20093466
KAR3_YEASTKAR3genetic
20093466
SML1_YEASTSML1genetic
10747050
KAPR_YEASTBCY1physical
20489023
PAA1_YEASTPAA1physical
20489023
LHS1_YEASTLHS1genetic
19325107
MGA2_YEASTMGA2genetic
19325107
OS9_YEASTYOS9genetic
19325107
PAA1_YEASTPAA1physical
20826334
PP2C3_YEASTPTC3genetic
21135129
PP2C1_YEASTPTC1genetic
21127252
TEC1_YEASTTEC1genetic
21127252
HAL4_YEASTSAT4genetic
21127252
CHK1_YEASTCHK1genetic
21127252
AP2_YEASTCAD1genetic
21127252
KCC4_YEASTKCC4genetic
21127252
PP2C3_YEASTPTC3genetic
12667463
PP2C3_YEASTPTC3genetic
25088474
PDP1_YEASTPTC5genetic
25088474
PP2C7_YEASTPTC7genetic
25088474
BRE1_YEASTBRE1genetic
27708008
ETR1_YEASTETR1genetic
27708008
PP4C_YEASTPPH3genetic
27708008
CGR1_YEASTCGR1genetic
27708008
SNF6_YEASTSNF6genetic
27708008
PDR11_YEASTPDR11genetic
27708008
ICE2_YEASTICE2genetic
27708008
ASF1_YEASTASF1genetic
27708008
PTK2_YEASTPTK2genetic
27708008
DHOM_YEASTHOM6genetic
27708008
YET1_YEASTYET1genetic
27708008
CYT2_YEASTCYT2genetic
27708008
LIPB_YEASTLIP2genetic
27708008
MMS22_YEASTMMS22genetic
27708008
FAP1_YEASTFAP1genetic
27708008
YNE0_YEASTYNL040Wgenetic
27708008
CUZ1_YEASTCUZ1genetic
27708008
NSG2_YEASTNSG2genetic
27708008
HOL1_YEASTHOL1genetic
27708008
DIA2_YEASTDIA2genetic
27708008
HSP7F_YEASTSSE1genetic
27708008
CTF4_YEASTCTF4genetic
27708008
KAR3_YEASTKAR3genetic
27708008
SLT2_YEASTSLT2physical
25736922
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PP2C2_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-327, AND MASSSPECTROMETRY.
"Quantitative phosphoproteomics applied to the yeast pheromonesignaling pathway.";
Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J.,Mann M., Jensen O.N.;
Mol. Cell. Proteomics 4:310-327(2005).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-327, AND MASSSPECTROMETRY.

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