TDA4_YEAST - dbPTM
TDA4_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID TDA4_YEAST
UniProt AC P47153
Protein Name Topoisomerase I damage affected protein 4
Gene Name TDA4
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 279
Subcellular Localization Membrane
Multi-pass membrane protein.
Protein Description
Protein Sequence MNANSTTTAIGLTSPFEKLSFFPHSSNLILAHLHEIIFSFVFYQLAFSVVAPFLNKVVFRKHYTTIRDPLLKIDFNVHTVSMIQAVVSNTVLLPTLTTPMHYNVVTYTDSYSSMVSSLSAGYFIWDLTMCVRYFKLYGLEFTGHAIGSVYVMLLSLRPFCQPWIGRFLIYEASTPFVNINWFIMQCNAKSKNSIPLWFNVVNGLLLMTVFFVVRICWGSIASALLFRQMWKVRDELPKFSAVTMMSLNIFMNLLNVLWFKKMIRIAKKLAKPAPTSKLD
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
5Phosphorylation---MNANSTTTAIGL
---CCCCCCCCCCCC		25.3922890988
6Phosphorylation--MNANSTTTAIGLT
--CCCCCCCCCCCCC		28.1522890988
7Phosphorylation-MNANSTTTAIGLTS
-CCCCCCCCCCCCCC		17.6622890988
8PhosphorylationMNANSTTTAIGLTSP
CCCCCCCCCCCCCCC		19.1622890988
13PhosphorylationTTTAIGLTSPFEKLS
CCCCCCCCCCCHHHC		29.1922890988
14PhosphorylationTTAIGLTSPFEKLSF
CCCCCCCCCCHHHCC		32.4122890988
276PhosphorylationLAKPAPTSKLD----
HCCCCCCCCCC----		30.1127017623
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of TDA4_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of TDA4_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of TDA4_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SRS2_YEASTSRS2genetic
21459050
AIF1_YEASTAIF1genetic
26752183
COX12_YEASTCOX12genetic
26752183
MCA1_YEASTMCA1genetic
26752183
MET30_YEASTMET30genetic
27708008
DPOA2_YEASTPOL12genetic
27708008
KPC1_YEASTPKC1genetic
27708008
TIM22_YEASTTIM22genetic
27708008
CDC1_YEASTCDC1genetic
27708008
RSP5_YEASTRSP5genetic
27708008
STT3_YEASTSTT3genetic
27708008
SED5_YEASTSED5genetic
27708008
SEC22_YEASTSEC22genetic
27708008
TAD3_YEASTTAD3genetic
27708008
BET5_YEASTBET5genetic
27708008
PSB5_YEASTPRE2genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of TDA4_YEAST

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Related Literatures of Post-Translational Modification

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