AIF1_YEAST - dbPTM
AIF1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID AIF1_YEAST
UniProt AC P52923
Protein Name Apoptosis-inducing factor 1
Gene Name AIF1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 378
Subcellular Localization Mitochondrion outer membrane
Single-pass membrane protein. Nucleus . Translocates from mitochondrion to the nucleus upon apoptosis induction.
Protein Description Putative FAD-dependent oxidoreductase involved in the resistance to cercosporin and other singlet oxygen-generating photosensitizers. Translocates from mitochondria to the nucleus under apoptotic conditions, where it degrades DNA and induces apoptosis..
Protein Sequence MTINTKNIVVVGAGVFGVSVANHLYRELGGTYAIKLVTASNYVYFLPSAVRLTVSKDYTKSILPLKNVLDSGIEVIKDTAASFDDKEVVLGSDRAIKFDILVLATGSKWADPIGSTYTFGDNYKEYFEREASRISDADHILFLGGGFVNCELAGELLFKYLEEIRSGKKRISIIHNSDKLLPDSGLYNDTLRKNVTDYLSKNGITLYLNTVGASLDTSPKRIFLGEGSSKYIDADLIYRGVGISPNVPVNSISDLCDKKGFIQVEKNFRVKAVEAGNVFAIGDVTNFRYHGLVKRDNWVDVLTRNVISSLQEGTEASLVDADCLETGHAPSGVSLGPNAGFGQFPLPLLGTINIPSFLISRAKSKNLFSDKMEPLFKK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
364PhosphorylationFLISRAKSKNLFSDK
HHHHHHHHCCCCCCC		26.2819684113
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of AIF1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of AIF1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of AIF1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
CASP8_HUMANCASP8genetic
19166881
CASPA_HUMANCASP10genetic
19166881
CSG2_YEASTCSG2genetic
20526336
YN8S_YEASTYNR048Wgenetic
20526336
CBP6_YEASTCBP6physical
22940862
CBP3_YEASTCBP3physical
22940862
TRPD_YEASTTRP4genetic
27708008
KCC1_YEASTCMK1genetic
27708008
RDR1_YEASTRDR1genetic
27708008
PDXH_YEASTYPR172Wgenetic
27708008
RL19A_YEASTRPL19Bgenetic
27708008
RL19B_YEASTRPL19Bgenetic
27708008
CHK1_YEASTCHK1genetic
27708008
MTU1_YEASTSLM3genetic
27708008
YD018_YEASTYDR018Cgenetic
27708008
SAC3_YEASTSAC3genetic
27708008
NBP2_YEASTNBP2genetic
27708008
MET32_YEASTMET32genetic
27708008
PMT7_YEASTPMT7genetic
27708008
RLA4_YEASTRPP2Bgenetic
27708008
YD541_YEASTYDR541Cgenetic
27708008
CGR1_YEASTCGR1genetic
27708008
SLI1_YEASTSLI1genetic
27708008
DAL81_YEASTDAL81genetic
27708008
YJ31_YEASTYJR061Wgenetic
27708008
ALAM_YEASTALT1genetic
27708008
TRM11_YEASTTRM11genetic
27708008
BRR1_YEASTBRR1genetic
27708008
MDJ1_YEASTMDJ1genetic
27453043
INO4_YEASTINO4genetic
27453043
SIN3_YEASTSIN3genetic
27453043
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of AIF1_YEAST

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Related Literatures of Post-Translational Modification

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