HFM1_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HFM1_YEAST
• UniProt AC: P51979
• Protein Name: ATP-dependent DNA helicase MER3
• Gene Name: HFM1
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 1187
• Subcellular Localization: Nucleus .
• Protein Description: DNA-dependent ATPase. Required in the control of double strand breaks transition and crossover during meiosis. Unwinds DNA in the 3' TO 5' direction. Prefers single-stranded DNA..
• Protein Sequence: MKTKFDRLGTGKRSRPSPNNIDFNDQSATFKRNKKNSRQPSFKVGLSYNSLLDDCDDENETEEIFEGRGLQFFDKDDNFSITADDTQVTSKLFDHDLEQTPDEEAKKPKKVTIRKSAKKCLSTTILPDSFRGVFKFTEFNKMQSEAFPSIYESNENCIISSPTGSGKTVLFELAILRLIKETNSDTNNTKIIYIAPTKSLCYEMYKNWFPSFVNLSVGMLTSDTSFLETEKAKKCNIIITTPEKWDLLTRRWSDYSRLFELVKLVLVDEIHTIKEKRGASLEVILTRMNTMCQNIRFVALSATVPNIEDLALWLKTNNELPANILSFDESYRQVQLTKFVYGYSFNCKNDFQKDAIYNSKLIEIIEKHADNRPVLIFCPTRASTISTAKFLLNNHIFSKSKKRCNHNPSDKILNECMQQGIAFHHAGISLEDRTAVEKEFLAGSINILCSTSTLAVGVNLPAYLVIIKGTKSWNSSEIQEYSDLDVLQMIGRAGRPQFETHGCAVIMTDSKMKQTYENLIHGTDVLESSLHLNLIEHLAAETSLETVYSIETAVNWLRNTFFYVRFGKNPAAYQEVNRYVSFHSVEDSQINQFCQYLLDTLVKVKIIDISNGEYKSTAYGNAMTRHYISFESMKQFINAKKFLSLQGILNLLATSEEFSVMRVRHNEKKLFKEINLSPLLKYPFLTEKKQSQIIDRVSQKVSLLIQYELGGLEFPSYEGASKLHQTLVQDKFLVFRHCFRLLKCMVDTFIEKSDGTSLKNTLFLLRSLNGHCWENTPMVLRQLKTIGLVSVRRLIRHGITNLEEMGHLSDTQIEYYLNLKIGNGIKIKNDISLLPCLNIRTKLENCKIENEELWLTFKVEISATFKSSIWHGQHLSLDIETEKSSGELIDFRRLQVNKLQSPRGFRISAKISPKLEKIEFSIHCQEIAGLGKTIVYSTDHLASQFSAKTPNIRKDLNSLEKCLFYESSSDGEVGKTSRVSHKDGLEESLSSDDSILDYLNERKKSSKAVESAAVIHPEAHSSSHFSNGRQVRSNGNYECFHSCKDKTQCRHLCCKEGIPVKYIKEKGPSSIKPVSKPDQIRQPLLAKNINTTPHLEKRLNSKPKQWQEENTDIATVHTLPSKIYNLSQQMSSMEAGEQVLKSGPENCPEIIPIDLESSDSYSSNTAASSISDPNGDLDFLGSDIEFE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
50	Phosphorylation	KVGLSYNSLLDDCDD EEEECHHHHHCCCCC	23.29	24930733
100	Phosphorylation	FDHDLEQTPDEEAKK HCCCHHCCCCHHHCC	24.27	27214570
182	Phosphorylation	ILRLIKETNSDTNNT HHHHHHHHCCCCCCE	34.71	22890988
184	Phosphorylation	RLIKETNSDTNNTKI HHHHHHCCCCCCEEE	53.91	22890988
186	Phosphorylation	IKETNSDTNNTKIIY HHHHCCCCCCEEEEE	30.13	22890988
189	Phosphorylation	TNSDTNNTKIIYIAP HCCCCCCEEEEEEEC	26.20	22890988
193	Phosphorylation	TNNTKIIYIAPTKSL CCCEEEEEEECCHHH	8.43	22890988
197	Phosphorylation	KIIYIAPTKSLCYEM EEEEEECCHHHHHHH	25.01	22890988
632	Phosphorylation	RHYISFESMKQFINA HHCCCHHHHHHHHCH	29.30	27017623
757	Phosphorylation	IEKSDGTSLKNTLFL HHCCCCCCHHHHHHH	42.76	27017623
761	Phosphorylation	DGTSLKNTLFLLRSL CCCCHHHHHHHHHHC	19.80	27017623
864	Phosphorylation	FKVEISATFKSSIWH EEEEEEEEECCCCCC	25.46	27017623
958	Phosphorylation	NIRKDLNSLEKCLFY CHHHHHHHHHHHHEE	45.24	27214570
967	Phosphorylation	EKCLFYESSSDGEVG HHHHEEECCCCCCCC	24.62	27214570
969	Phosphorylation	CLFYESSSDGEVGKT HHEEECCCCCCCCEE	59.94	27214570
1033	Phosphorylation	SNGRQVRSNGNYECF CCCCEEECCCCCCCC	50.67	27214570
1092	Phosphorylation	LAKNINTTPHLEKRL HHCCCCCCHHHHHHH	12.29	27214570
1127	Phosphorylation	PSKIYNLSQQMSSME HHHHHCHHHHHHHHH	18.09	27017623
1132	Phosphorylation	NLSQQMSSMEAGEQV CHHHHHHHHHHHHHH	18.46	27017623

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HFM1_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HFM1_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HFM1_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SGS1_YEAST	SGS1	genetic	17002499
URE2_YEAST	URE2	physical	18467557
MLH1_YEAST	MLH1	physical	28051769
MLH2_YEAST	MLH2	physical	28051769

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.