RKM4_YEAST - dbPTM
RKM4_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID RKM4_YEAST
UniProt AC Q12504
Protein Name Ribosomal lysine N-methyltransferase 4 {ECO:0000303|PubMed:18957409}
Gene Name RKM4 {ECO:0000303|PubMed:18957409}
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 494
Subcellular Localization Nucleus .
Protein Description S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that monomethylates 60S ribosomal protein L42 (RPL42A and RPL42B) at 'Lys-55'..
Protein Sequence MDDFSRDTENFVCWLKTTAEIEVSPKIEIKDLCCDNQGRAVVATQKIKKDETLFKIPRSSVLSVTTSQLIKDYPSLKDKFLNETGSWEGLIICILYEMEVLQERSRWAPYFKVWNKPSDMNALIFWDDNELQLLKPSLVLERIGKKEAKEMHERIIKSIKQIGGEFSRVATSFEFDNFAYIASIILSYSFDLEMQDSSVNENEEEETSEEELENERYLKSMIPLADMLNADTSKCNANLTYDSNCLKMVALRDIEKNEQVYNIYGEHPNSELLRRYGYVEWDGSKYDFGEVLLENIVEALKETFETNTEFLDRCIDILRNNANIQEFLEGEEIVLDSYDCYNNGELLPQLILLVQILTILCQIPGLCKLDIKAMERQVERIVKKCLQLIEGARATTNCSATWKRCIMKRLADYPIKKCVSIEKPSKGNSLTREELRDVMARRVLKSEIDSLQVCEETIDKNYKVIPDEKLLTNILKRKLTEEEKSSVKRPCVKK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
44PhosphorylationQGRAVVATQKIKKDE
CCCEEEEEEEECCCC		20.8428889911
55AcetylationKKDETLFKIPRSSVL
CCCCCCCCCCHHHHC		55.7122865919
59PhosphorylationTLFKIPRSSVLSVTT
CCCCCCHHHHCEEEH		21.3119823750
60PhosphorylationLFKIPRSSVLSVTTS
CCCCCHHHHCEEEHH		28.4919823750
63PhosphorylationIPRSSVLSVTTSQLI
CCHHHHCEEEHHHHH		18.4319823750
65PhosphorylationRSSVLSVTTSQLIKD
HHHHCEEEHHHHHHH		19.8419823750
66PhosphorylationSSVLSVTTSQLIKDY
HHHCEEEHHHHHHHC		16.6019823750
67PhosphorylationSVLSVTTSQLIKDYP
HHCEEEHHHHHHHCH		17.3919823750
217PhosphorylationEELENERYLKSMIPL
HHHHHHHHHHHHHHH		16.5927017623
220PhosphorylationENERYLKSMIPLADM
HHHHHHHHHHHHHHH		21.2527017623
233PhosphorylationDMLNADTSKCNANLT
HHHCCCCCCCCCCCC		35.4427017623
469AcetylationYKVIPDEKLLTNILK
CCCCCCHHHHHHHHH		57.0624489116
480PhosphorylationNILKRKLTEEEKSSV
HHHHHCCCHHHHHHC		44.3727214570
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of RKM4_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of RKM4_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of RKM4_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SLX5_YEASTSLX5genetic
17314980
VPS8_YEASTVPS8genetic
17314980
SWC3_YEASTSWC3genetic
17314980
RKM3_YEASTRKM3genetic
18957409
SRS2_YEASTSRS2genetic
7498783
RS8A_YEASTRPS8Agenetic
20093466
RS8B_YEASTRPS8Agenetic
20093466
RV161_YEASTRVS161genetic
20093466
UBC13_YEASTUBC13genetic
20093466
PEA2_YEASTPEA2genetic
20093466
SIC1_YEASTSIC1genetic
20093466
RS3A2_YEASTRPS1Bgenetic
20093466
SOK2_YEASTSOK2genetic
20093466
PFKA2_YEASTPFK2genetic
20093466
ADE_YEASTAAH1genetic
20093466
MAS5_YEASTYDJ1genetic
20093466
INO4_YEASTINO4genetic
20093466
SUR1_YEASTSUR1genetic
20093466
HAP3_YEASTHAP3genetic
20959818
RIO1_YEASTRIO1physical
21460040
DEP1_YEASTDEP1genetic
27708008
TPS1_YEASTTPS1genetic
27708008
RV161_YEASTRVS161genetic
27708008
GPR1_YEASTGPR1genetic
27708008
RLA1_YEASTRPP1Agenetic
27708008
UBC13_YEASTUBC13genetic
27708008
RV167_YEASTRVS167genetic
27708008
DOT1_YEASTDOT1genetic
27708008
SLX9_YEASTSLX9genetic
27708008
ICE2_YEASTICE2genetic
27708008
QDR1_YEASTQDR1genetic
27708008
RL14A_YEASTRPL14Agenetic
27708008
LST4_YEASTLST4genetic
27708008
RL22A_YEASTRPL22Agenetic
27708008
SIC1_YEASTSIC1genetic
27708008
PFKA2_YEASTPFK2genetic
27708008
MAS5_YEASTYDJ1genetic
27708008
VPS27_YEASTVPS27genetic
27708008
INO4_YEASTINO4genetic
27708008
SUR1_YEASTSUR1genetic
27708008
VPS4_YEASTVPS4genetic
27708008
DOM34_YEASTDOM34genetic
29158977
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of RKM4_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-44, AND MASSSPECTROMETRY.

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