dbPTM

RKM3_YEAST - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	RKM3_YEAST
UniProt AC	P38222
Protein Name	Ribosomal lysine N-methyltransferase 3 {ECO:0000303\|PubMed:18957409}
Gene Name	RKM3 {ECO:0000303\|PubMed:18957409}
Organism	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length	552
Subcellular Localization	Nucleus .
Protein Description	S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that monomethylates 60S ribosomal protein L42 (RPL42A and RPL42B) at 'Lys-40'..
Protein Sequence	MSVTFKDDVHRILKFVANCNGRFEDSKCDIRESPLGGLGVFAKTDIAEGESILTLNKSSIFSASNSSIANLLCDSSIDGMLALNIAFIYETTVFRNSSHWYPFLRTIRIRDDEGHLNLPPSFWHADAKRLLKGTSFDTLFDSLAPEEEIMEGFEIAVDLAHKWNDEFGLEIPKGFLDVSEENHEEDYNLKLEKFISVAYTLSSRGFEIDAYHETALVPIADLFNHHVSDPDLKFVSLYDVCDKCGEPDMCKHLIAEEYLEAENLDKNMPKVASMETRVIDEDLIKSLENDLEKEYSNVTANIEDDDGGIENPDECVDLVLKNDVAQGQEIFNSYGELSNVFLLARYGFTVPENQYDIVHLGPDFMKILKKEEKYQEKVKWWSQVGHGLFSAWYAQMRQEDEEDEDGQAKSDNLSDDIESEEEEEEEEGDDSLESWLSQLYIDSSGEPSPSTWALANLLTLTAVQWESLFSKKATPHISDSIVNEEKLPFLAKKDNPHSKKLLSNLLKEKQLPCIKGDNSSKITSATKSMLQNARTLVQSEHNILDRCLKRLS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference	Orthologous Protein Cluster
6	Acetylation	--MSVTFKDDVHRIL --CCCCCHHHHHHHH	43.59	24489116
273	Phosphorylation	KNMPKVASMETRVID CCCCCCCCCEEEECC	21.82	30377154

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of RKM3_YEAST !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of RKM3_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of RKM3_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MLC1_YEAST	MLC1	physical	16554755
MAP1_YEAST	MAP1	physical	16554755
H2A2_YEAST	HTA2	genetic	17314980
ASF1_YEAST	ASF1	genetic	19269370
TECR_YEAST	TSC13	genetic	27708008
TIM22_YEAST	TIM22	genetic	27708008
CDC4_YEAST	CDC4	genetic	27708008
GPI10_YEAST	GPI10	genetic	27708008
TEL2_YEAST	TEL2	genetic	27708008
DPOD2_YEAST	POL31	genetic	27708008
SEC22_YEAST	SEC22	genetic	27708008
MED10_YEAST	NUT2	genetic	27708008
SCY1_YEAST	SCY1	genetic	27708008
SNF6_YEAST	SNF6	genetic	27708008
THIK_YEAST	POT1	genetic	27708008
SCS7_YEAST	SCS7	genetic	27708008
PHO23_YEAST	PHO23	genetic	27708008
YN8H_YEAST	YNR029C	genetic	27708008
SNC2_YEAST	SNC2	genetic	27708008
TBP6_YEAST	YTA6	genetic	27708008
YIG1_YEAST	YIG1	genetic	27708008
DAD1_YEAST	DAD1	genetic	29674565
INO2_YEAST	INO2	genetic	29674565
PT122_YEAST	PET122	genetic	29674565
HSP7F_YEAST	SSE1	genetic	29674565
CAK1_YEAST	CAK1	genetic	29674565

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of RKM3_YEAST

Related Literatures of Post-Translational Modification