| UniProt ID | ACEA_YEAST | |
|---|---|---|
| UniProt AC | P28240 | |
| Protein Name | Isocitrate lyase {ECO:0000303|PubMed:1551398} | |
| Gene Name | ICL1 {ECO:0000303|PubMed:1551398} | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 557 | |
| Subcellular Localization | Cytoplasm . Secreted, extracellular space, extracellular matrix . Vacuole . Localizes in extracellular vesicles during growth on lown glucose. When glucose is added to glucose-starved wild-type cells, levels of extracellular ICL1 get reduced. Targete | |
| Protein Description | Catalyzes the formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle, which operates as an anaplerotic route for replenishing the tricarboxylic acid cycle. Required for growth on ethanol or acetate, but dispensable when fermentable carbon sources are available. Acts also on 2-methylisocitrate.. | |
| Protein Sequence | MPIPVGNTKNDFAALQAKLDADAAEIEKWWSDSRWSKTKRNYSARDIAVRRGTFPPIEYPSSVMARKLFKVLEKHHNEGTVSKTFGALDPVQISQMAKYLDTIYISGWQCSSTASTSNEPGPDLADYPMDTVPNKVEHLFKAQLFHDRKQLEARSKAKSQEELDEMGAPIDYLTPIVADADAGHGGLTAVFKLTKMFIERGAAGIHMEDQTSTNKKCGHMAGRCVIPVQEHVNRLVTIRMCADIMHSDLIVVARTDSEAATLISSTIDTRDHYFIVGATNPNIEPFAEVLNDAIMSGASGQELADIEQKWCRDAGLKLFHEAVIDEIERSALSNKQELIKKFTSKVGPLTETSHREAKKLAKEILGHEIFFDWELPRVREGLYRYRGGTQCSIMRARAFAPYADLVWMESNYPDFQQAKEFAEGVKEKFPDQWLAYNLSPSFNWPKAMSVDEQHTFIQRLGDLGYIWQFITLAGLHTNALAVHNFSRDFAKDGMKAYAQNVQQREMDDGVDVLKHQKWSGAEYIDGLLKLAQGGVSATAAMGTGVTEDQFKENGVKK | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 53 | Phosphorylation | DIAVRRGTFPPIEYP HHHHHHCCCCCCCCC | 31.02 | - | |
| 59 | Phosphorylation | GTFPPIEYPSSVMAR CCCCCCCCCHHHHHH | 14.77 | 19779198 | |
| 61 | Phosphorylation | FPPIEYPSSVMARKL CCCCCCCHHHHHHHH | 34.36 | 19779198 | |
| 255 | Phosphorylation | DLIVVARTDSEAATL CEEEEEECCHHHHHH | 33.85 | 27214570 | |
| 265 | Phosphorylation | EAATLISSTIDTRDH HHHHHHHCCCCCCCC | 23.53 | 30377154 | |
| 519 | Phosphorylation | VLKHQKWSGAEYIDG HHHHCCCCCHHHHHH | 34.85 | 30377154 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of ACEA_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of ACEA_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of ACEA_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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