| UniProt ID | TYDP1_YEAST | |
|---|---|---|
| UniProt AC | P38319 | |
| Protein Name | Tyrosyl-DNA phosphodiesterase 1 | |
| Gene Name | TDP1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 544 | |
| Subcellular Localization | Nucleus . | |
| Protein Description | DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 3'-phosphodiester bond, giving rise to DNA with a free 3' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase I active site tyrosine residue. Hydrolyzes 3'-phosphoglycolates on protruding 3' ends on DNA double-strand breaks due to DNA damage by radiation and free radicals. Cleaves also 5' phosphotyrosyl adducts resulting from dead-end complexes between DNA and the active site tyrosine of topoisomerase II. Contributes to DNA repair after radiation damage. Acts on blunt-ended double-strand DNA breaks and on single-stranded DNA. May have low 3'exonuclease activity and may be able to remove a single nucleoside from the 3'end of DNA and RNA molecules with 3'hydroxyl groups. Has no exonuclease activity towards DNA or RNA with a 3'phosphate (By similarity).. | |
| Protein Sequence | MSRETNFNGTKRKRSDVAEKVAQRWKSVRYSAEMENMAPVNSNNDSDDCVIVSESKIIDLTNQEQDLSERIETNDTAKGAVFKLMKSDFYEREDFMGEVEDMITLKDIFGTETLKRSILFSFQYELDFLLRQFHQNVENITIVGQKGTIMPIEARAMDATLAVILKKVKLIEITMPPFASHHTKLIINFYDNGECKIFLPSNNFTSMETNLPQQVCWCSPLLKIGKEGLPVPFKRSLIEYLNSYHLKDIDELITKSVEEVNFAPLSELEFVYSTPSKFQSSGLLSFYNKLEKLSAGTSASDTAKHYLCQTSSIGTSLSRARDENLWTHLMIPLFTGIMSPPAKDTAGRKKAEILPTNSLINEYSQRKIKPYIIFPTEQEFVTSPLKWSSSGWFHFQYLQKKSYYEMLRNKFKVFYKQDPAMVTRRRGTTPAHSKFYMHCATNSAGPCDASQVFKELEWCLYTSANLSQTAWGTVSRKPRNYEAGVLYHSRRLANTRKVTCRTFTRDRRGCAGNPTHVAVPFTLPVIPYDLAEDECFCLARHEND | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 20 | Acetylation | KRSDVAEKVAQRWKS CHHHHHHHHHHHHHH | 32.88 | 25381059 | |
| 42 | Phosphorylation | ENMAPVNSNNDSDDC HCCCCCCCCCCCCCE | 36.93 | 20377248 | |
| 46 | Phosphorylation | PVNSNNDSDDCVIVS CCCCCCCCCCEEEEE | 37.16 | 21551504 | |
| 68 | Phosphorylation | TNQEQDLSERIETND CCCCCCHHHHHHCCH | 32.87 | 27017623 | |
| 306 | Phosphorylation | ASDTAKHYLCQTSSI CHHHHHHHHHHHCCC | 14.41 | 22890988 | |
| 312 | Phosphorylation | HYLCQTSSIGTSLSR HHHHHHCCCCCHHHH | 28.55 | 22890988 | |
| 318 | Phosphorylation | SSIGTSLSRARDENL CCCCCHHHHHHCCCH | 24.54 | 22890988 | |
| 481 | Phosphorylation | VSRKPRNYEAGVLYH CCCCCCCCCCHHHHH | 14.40 | 28889911 | |
| 487 | Phosphorylation | NYEAGVLYHSRRLAN CCCCHHHHHHHHCCC | 8.71 | 28889911 | |
| 489 | Phosphorylation | EAGVLYHSRRLANTR CCHHHHHHHHCCCCC | 12.92 | 28889911 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of TYDP1_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of TYDP1_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of TYDP1_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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