APN1_YEAST - dbPTM
APN1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID APN1_YEAST
UniProt AC P22936
Protein Name DNA-(apurinic or apyrimidinic site) lyase 1
Gene Name APN1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 367
Subcellular Localization Nucleus.
Protein Description DNA repair enzyme that cleaves apurinic/apyrimidinic (AP) sites and removes 3'-blocking groups present at single strand breaks of damaged DNA. APN1 accounts for > 97% of both apurinic/ apyrimidinic (AP) lyase and DNA 3'-repair diesterase activities..
Protein Sequence MPSTPSFVRSAVSKYKFGAHMSGAGGISNSVTNAFNTGCNSFAMFLKSPRKWVSPQYTQEEIDKFKKNCATYNYNPLTDVLPHGQYFINLANPDREKAEKSYESFMDDLNRCEQLGIGLYNLHPGSTLKGDHQLQLKQLASYLNKAIKETKFVKIVLENMAGTGNLVGSSLVDLKEVIGMIEDKSRIGVCIDTCHTFAAGYDISTTETFNNFWKEFNDVIGFKYLSAVHLNDSKAPLGANRDLHERLGQGYLGIDVFRMIAHSEYLQGIPIVLETPYENDEGYGNEIKLMEWLESKSESELLEDKEYKEKNDTLQKLGAKSRKEQLDKFEVKQKKRAGGTKRKKATAEPSDNDILSQMTKKRKTKKE
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
3Phosphorylation-----MPSTPSFVRS
-----CCCCHHHHHH		52.2122369663
4Phosphorylation----MPSTPSFVRSA
----CCCCHHHHHHH		19.6522369663
54PhosphorylationKSPRKWVSPQYTQEE
HCCCCCCCCCCCHHH		12.7427017623
57PhosphorylationRKWVSPQYTQEEIDK
CCCCCCCCCHHHHHH		17.4927017623
58PhosphorylationKWVSPQYTQEEIDKF
CCCCCCCCHHHHHHH		25.0227017623
295PhosphorylationKLMEWLESKSESELL
HHHHHHHCCCHHHHH		39.0322369663
297PhosphorylationMEWLESKSESELLED
HHHHHCCCHHHHHCC		56.4822369663
299PhosphorylationWLESKSESELLEDKE
HHHCCCHHHHHCCHH		40.4121440633
316AcetylationEKNDTLQKLGAKSRK
HHHHHHHHHHHHHHH		52.5922865919
328AcetylationSRKEQLDKFEVKQKK
HHHHHHHHHHHHHHH		52.6024489116
346PhosphorylationGTKRKKATAEPSDND
CCCCCCCCCCCCHHH		40.2028889911
350PhosphorylationKKATAEPSDNDILSQ
CCCCCCCCHHHHHHH		40.3225752575
356PhosphorylationPSDNDILSQMTKKRK
CCHHHHHHHHHHHCC		20.4528889911
359PhosphorylationNDILSQMTKKRKTKK
HHHHHHHHHHCCCCC		26.2730377154
360AcetylationDILSQMTKKRKTKKE
HHHHHHHHHCCCCCC		45.2825381059
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of APN1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of APN1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of APN1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
PIR1_YEASTPIR1physical
11238901
APN2_YEASTAPN2genetic
14697759
MPH1_YEASTMPH1genetic
10880470
RAD14_YEASTRAD14genetic
10779341
RAD2_YEASTRAD2genetic
10779341
RAD4_YEASTRAD4genetic
10779341
APN2_YEASTAPN2genetic
9765213
RAD1_YEASTRAD1genetic
9506896
RAD10_YEASTRAD10genetic
9506896
APN2_YEASTAPN2genetic
14585995
APN2_YEASTAPN2genetic
12032096
APN2_YEASTAPN2genetic
12882322
RAD52_YEASTRAD52genetic
11585902
MAG_YEASTMAG1genetic
14697759
APN2_YEASTAPN2genetic
10022867
RIM1_YEASTRIM1physical
16554755
YRA1_YEASTYRA1physical
16554755
IMA1_YEASTSRP1physical
16554755
H1_YEASTHHO1physical
16554755
APN2_YEASTAPN2genetic
16793364
RAD18_YEASTRAD18genetic
17314980
RAD4_YEASTRAD4genetic
17314980
SAW1_YEASTSAW1genetic
17314980
SAC3_YEASTSAC3genetic
17314980
APN2_YEASTAPN2genetic
12482989
WRIP1_YEASTMGS1genetic
12436259
MAG_YEASTMAG1genetic
18267974
DOT1_YEASTDOT1genetic
18562671
APN2_YEASTAPN2genetic
19712668
NTH1_YEASTNTG1genetic
19712668
NTH2_YEASTNTG2genetic
19712668
NTH1_YEASTNTG1genetic
19448611
NTH2_YEASTNTG2genetic
19448611
MAG_YEASTMAG1genetic
18043759
MSH1_YEASTMSH1genetic
19056520
APN2_YEASTAPN2genetic
19955329
TPP1_YEASTTPP1genetic
19955329
XRS2_YEASTXRS2genetic
20040573
NTH1_YEASTNTG1genetic
20040573
NTH2_YEASTNTG2genetic
20040573
APN2_YEASTAPN2genetic
11738940
MAG_YEASTMAG1genetic
11738940
DPOZ_YEASTREV3genetic
11738940
APN2_YEASTAPN2genetic
12397185
RAD10_YEASTRAD10genetic
15371342
RAD1_YEASTRAD1genetic
15371342
RAD2_YEASTRAD2genetic
15371342
UNG_YEASTUNG1genetic
14585995
DUT_YEASTDUT1genetic
14585995
DPOZ_YEASTREV3genetic
12807766
RAD1_YEASTRAD1genetic
12807766
RAD52_YEASTRAD52genetic
12807766
RAD18_YEASTRAD18genetic
12807766
APTX_YEASTHNT3genetic
20399152
RAD14_YEASTRAD14genetic
20421413
UNG_YEASTUNG1genetic
20421413
DPOZ_YEASTREV3genetic
20421413
NTH1_YEASTNTG1genetic
20421413
NTH2_YEASTNTG2genetic
20421413
RAD26_YEASTRAD26genetic
20421413
RAD7_YEASTRAD7genetic
20421413
RAD1_YEASTRAD1genetic
12032096
RAD10_YEASTRAD10genetic
12032096
RCK2_YEASTRCK2physical
21460040
APN2_YEASTAPN2genetic
22226374
UNG_YEASTUNG1genetic
22226374
RAD9_YEASTRAD9genetic
22226374
ATR_YEASTMEC1genetic
22226374
SML1_YEASTSML1genetic
22226374
RAD53_YEASTRAD53genetic
22226374
RAD17_YEASTRAD17genetic
22226374
RAD24_YEASTRAD24genetic
22226374
DDC1_YEASTDDC1genetic
22226374
DPOZ_YEASTREV3genetic
22226374
RAD14_YEASTRAD14genetic
22226374
RAD51_YEASTRAD51genetic
22226374
MMS2_YEASTMMS2genetic
22226374
NTH1_YEASTNTG1genetic
22226374
NTH2_YEASTNTG2genetic
22226374
TPP1_YEASTTPP1genetic
12783866
APN2_YEASTAPN2genetic
12783866
RAD1_YEASTRAD1genetic
12783866
NTH1_YEASTNTG1genetic
22818187
NTH2_YEASTNTG2genetic
22818187
ATR_YEASTMEC1genetic
19540258
EXO1_YEASTEXO1genetic
19540258
RAD1_YEASTRAD1genetic
15687272
CHK1_YEASTCHK1genetic
15687272
RAD9_YEASTRAD9genetic
15687272
DUN1_YEASTDUN1genetic
15687272
SML1_YEASTSML1genetic
15687272
RAD17_YEASTRAD17genetic
15687272
MEC3_YEASTMEC3genetic
15687272
DDC1_YEASTDDC1genetic
15687272
RAD24_YEASTRAD24genetic
15687272
RAD53_YEASTRAD53genetic
15687272
RT107_YEASTRTT107genetic
15687272
TOF1_YEASTTOF1genetic
15687272
MRC1_YEASTMRC1genetic
15687272
MAD2_YEASTMAD2genetic
15687272
SECU_YEASTPDS1genetic
15687272
UNG_YEASTUNG1genetic
15687272
APN2_YEASTAPN2genetic
27708008
APE3_YEASTAPE3genetic
27708008
PCY1_YEASTPCT1genetic
27708008
ALN_YEASTDAL1genetic
27708008
RAD5_YEASTRAD5genetic
27708008
TOP3_YEASTTOP3genetic
27708008
PHO80_YEASTPHO80genetic
27708008
NTH1_YEASTNTG1genetic
27298254
NTH2_YEASTNTG2genetic
27298254
APN2_YEASTAPN2genetic
28334887
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of APN1_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-4, AND MASSSPECTROMETRY.

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