APE3_YEAST - dbPTM
APE3_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID APE3_YEAST
UniProt AC P37302
Protein Name Aminopeptidase Y
Gene Name APE3
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 537
Subcellular Localization Vacuole. Lysosome-like vacuoles.
Protein Description
Protein Sequence MHFSLKQLAVAAFYATNLGSAYVIPQFFQEAFQQEEPIENYLPQLNDDDSSAVAANIPKPHIPYFMKPHVESEKLQDKIKVDDLNATAWDLYRLANYSTPDYGHPTRVIGSKGHNKTMEYILNVFDDMQDYYDVSLQEFEALSGKIISFNLSDAETGKSFANTTAFALSPPVDGFVGKLVEIPNLGCEEKDYASVVPPRHNEKQIALIERGKCPFGDKSNLAGKFGFTAVVIYDNEPKSKEGLHGTLGEPTKHTVATVGVPYKVGKKLIANIALNIDYSLYFAMDSYVEFIKTQNIIADTKHGDPDNIVALGAHSDSVEEGPGINDDGSGTISLLNVAKQLTHFKINNKVRFAWWAAEEEGLLGSNFYAYNLTKEENSKIRVFMDYDMMASPNYEYEIYDANNKENPKGSEELKNLYVDYYKAHHLNYTLVPFDGRSDYVGFINNGIPAGGIATGAEKNNVNNGKVLDRCYHQLCDDVSNLSWDAFITNTKLIAHSVATYADSFEGFPKRETQKHKEVDILNAQQPQFKYRADFLII
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
67AcetylationPHIPYFMKPHVESEK
CCCCCCCCCCCCCHH		23.2822865919
74AcetylationKPHVESEKLQDKIKV
CCCCCCHHHHCCCCC		61.8122865919
85N-linked_GlycosylationKIKVDDLNATAWDLY
CCCCCCCCCHHHHHH		42.09-
96N-linked_GlycosylationWDLYRLANYSTPDYG
HHHHHHHCCCCCCCC		35.56-
115N-linked_GlycosylationVIGSKGHNKTMEYIL
EECCCCCHHHHHHHH		50.60-
150N-linked_GlycosylationSGKIISFNLSDAETG
CCCEEEEECCHHHCC		31.67-
162N-linked_GlycosylationETGKSFANTTAFALS
HCCCCCCCCCCHHCC		35.63-
187GlutathionylationVEIPNLGCEEKDYAS
EECCCCCCCCCCCCC		7.4222833525
190AcetylationPNLGCEEKDYASVVP
CCCCCCCCCCCCCCC		33.4724489116
203AcetylationVPPRHNEKQIALIER
CCCCCCHHHEEEEEC		52.9324489116
218AcetylationGKCPFGDKSNLAGKF
CCCCCCCCCCCCCCC		41.4425381059
252AcetylationGTLGEPTKHTVATVG
CCCCCCCCCCEEECC		48.2524489116
254PhosphorylationLGEPTKHTVATVGVP
CCCCCCCCEEECCCC		17.2522369663
257PhosphorylationPTKHTVATVGVPYKV
CCCCCEEECCCCCHH		17.2922369663
262PhosphorylationVATVGVPYKVGKKLI
EEECCCCCHHCCHHH		18.8522369663
263SuccinylationATVGVPYKVGKKLIA
EECCCCCHHCCHHHH		38.1423954790
263AcetylationATVGVPYKVGKKLIA
EECCCCCHHCCHHHH		38.1424489116
278PhosphorylationNIALNIDYSLYFAMD
HHCCCCCHHHHHHHH		9.2229650682
287PhosphorylationLYFAMDSYVEFIKTQ
HHHHHHHHHHHHHHC		10.3429650682
3492-HydroxyisobutyrylationTHFKINNKVRFAWWA
CCEEECCEEEEEEEE		30.24-
371N-linked_GlycosylationGSNFYAYNLTKEENS
CCCEEEEECCCCCCC		32.82-
3792-HydroxyisobutyrylationLTKEENSKIRVFMDY
CCCCCCCCEEEEECC		46.22-
386PhosphorylationKIRVFMDYDMMASPN
CEEEEECCCCCCCCC		8.2424961812
391PhosphorylationMDYDMMASPNYEYEI
ECCCCCCCCCEEEEE		8.8624961812
404AcetylationEIYDANNKENPKGSE
EEEECCCCCCCCCCH		59.6924489116
414AcetylationPKGSEELKNLYVDYY
CCCCHHHHHHHHHHH		48.4624489116
427N-linked_GlycosylationYYKAHHLNYTLVPFD
HHHHHHCCEEEEECC		24.32-
437PhosphorylationLVPFDGRSDYVGFIN
EEECCCCCCCEEEEC		38.5328132839
458AcetylationGIATGAEKNNVNNGK
CCCCCCHHCCCCCCH		53.9724489116
465AcetylationKNNVNNGKVLDRCYH
HCCCCCCHHHHHHHH		41.5722865919
470GlutathionylationNGKVLDRCYHQLCDD
CCHHHHHHHHHHHHC		3.3822833525
475GlutathionylationDRCYHQLCDDVSNLS
HHHHHHHHHCHHHCC		3.1822833525
480N-linked_GlycosylationQLCDDVSNLSWDAFI
HHHHCHHHCCHHEEE		37.63-
496PhosphorylationNTKLIAHSVATYADS
CCHHHHHHHHHHHHC		12.3919823750
499PhosphorylationLIAHSVATYADSFEG
HHHHHHHHHHHCCCC		19.6519823750
500PhosphorylationIAHSVATYADSFEGF
HHHHHHHHHHCCCCC		9.9319823750
503PhosphorylationSVATYADSFEGFPKR
HHHHHHHCCCCCCHH		19.6119823750
509AcetylationDSFEGFPKRETQKHK
HCCCCCCHHCCCCCC		61.6824489116
516AcetylationKRETQKHKEVDILNA
HHCCCCCCCCCCCCC		67.4824489116
529AcetylationNAQQPQFKYRADFLI
CCCCCCCCCCCCEEE		28.6924489116
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of APE3_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of APE3_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of APE3_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
OS9_YEASTYOS9genetic
19325107
ATC3_YEASTDRS2genetic
27708008
YAJ9_YEASTYAR029Wgenetic
27708008
BUD31_YEASTBUD31genetic
27708008
YD090_YEASTYDR090Cgenetic
27708008
RAD4_YEASTRAD4genetic
27708008
HSP12_YEASTHSP12genetic
27708008
ASK10_YEASTASK10genetic
27708008
PTH_YEASTPTH1genetic
27708008
PIR5_YEASTYJL160Cgenetic
27708008
ENV10_YEASTENV10genetic
27708008
RAD14_YEASTRAD14genetic
27708008
RAD1_YEASTRAD1genetic
27708008
KA120_YEASTKAP120genetic
27708008
KAR3_YEASTKAR3genetic
27708008
HPA2_YEASTHPA2genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of APE3_YEAST

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Related Literatures of Post-Translational Modification

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