RHO5_YEAST - dbPTM
RHO5_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID RHO5_YEAST
UniProt AC P53879
Protein Name GTP-binding protein RHO5
Gene Name RHO5
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 331
Subcellular Localization Cell membrane
Lipid-anchor
Cytoplasmic side .
Protein Description Negatively regulates a MAP kinase branch, downstream of SLT2, of the PKC1-mediated signal transduction pathway..
Protein Sequence MRSIKCVIIGDGAVGKTSLLISYTTNSFPTDYVPTVFDNYSTTIAIPNGTASSPLELDNGNDKRGSLSSASSSPSTDRKLYKINLWDTAGQEDYDRLRPLCYPQTDIFLICFSVSEHASFANVTEKWLPELKQTSNIEGTSLYTKLGKYPILLVGTKSDLRDDPATQKKLQEANSDYVSQEEIDELVQRCGFMGYTECSAATQAGVREVFEQAVRYAIYEPESPNQKSANHTLTDELTTATTNTNGDKNIREQKQQPHHNNSTDSTLPKGSLQQEKEALNIKPTKKGQKDKIHEQSKSKGSKIASNNHHNKQAKPKTRNDKKKKKSKCVIL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
66PhosphorylationNGNDKRGSLSSASSS
CCCCCCCCCCCCCCC		29.1622369663
68PhosphorylationNDKRGSLSSASSSPS
CCCCCCCCCCCCCCC		26.0922369663
69PhosphorylationDKRGSLSSASSSPST
CCCCCCCCCCCCCCC		37.1522369663
71PhosphorylationRGSLSSASSSPSTDR
CCCCCCCCCCCCCCC		33.0422369663
72PhosphorylationGSLSSASSSPSTDRK
CCCCCCCCCCCCCCC		46.0822369663
73PhosphorylationSLSSASSSPSTDRKL
CCCCCCCCCCCCCCE		22.0022369663
75PhosphorylationSSASSSPSTDRKLYK
CCCCCCCCCCCCEEE		44.9122369663
76PhosphorylationSASSSPSTDRKLYKI
CCCCCCCCCCCEEEE		43.1122369663
82AcetylationSTDRKLYKINLWDTA
CCCCCEEEEECCCCC		35.2424489116
169UbiquitinationDDPATQKKLQEANSD
CCHHHHHHHHHHCCC		45.6523749301
219PhosphorylationQAVRYAIYEPESPNQ
HHHHHHHCCCCCCCC		19.7729688323
223PhosphorylationYAIYEPESPNQKSAN
HHHCCCCCCCCCCCC		39.6122369663
227UbiquitinationEPESPNQKSANHTLT
CCCCCCCCCCCCCCC		59.1723749301
228PhosphorylationPESPNQKSANHTLTD
CCCCCCCCCCCCCCH		25.2522369663
232PhosphorylationNQKSANHTLTDELTT
CCCCCCCCCCHHHHH		31.0322369663
234PhosphorylationKSANHTLTDELTTAT
CCCCCCCCHHHHHHC		28.6922369663
238PhosphorylationHTLTDELTTATTNTN
CCCCHHHHHHCCCCC		16.6122369663
239PhosphorylationTLTDELTTATTNTNG
CCCHHHHHHCCCCCC		34.3322369663
241PhosphorylationTDELTTATTNTNGDK
CHHHHHHCCCCCCCC		20.6322369663
242PhosphorylationDELTTATTNTNGDKN
HHHHHHCCCCCCCCC		37.2722369663
244PhosphorylationLTTATTNTNGDKNIR
HHHHCCCCCCCCCHH		38.1922369663
248AcetylationTTNTNGDKNIREQKQ
CCCCCCCCCHHHHHC		56.5224489116
248UbiquitinationTTNTNGDKNIREQKQ
CCCCCCCCCHHHHHC		56.5223749301
262PhosphorylationQQPHHNNSTDSTLPK
CCCCCCCCCCCCCCC		38.6222369663
263PhosphorylationQPHHNNSTDSTLPKG
CCCCCCCCCCCCCCC		35.7722369663
265PhosphorylationHHNNSTDSTLPKGSL
CCCCCCCCCCCCCCH		31.7522369663
266PhosphorylationHNNSTDSTLPKGSLQ
CCCCCCCCCCCCCHH		50.3022369663
271PhosphorylationDSTLPKGSLQQEKEA
CCCCCCCCHHHHHHH		29.1822369663
276UbiquitinationKGSLQQEKEALNIKP
CCCHHHHHHHHCCCC		43.9023749301
328GeranylgeranylationKKKKKSKCVIL----
HHCCCCCCEEC----		2.72-
328MethylationKKKKKSKCVIL----
HHCCCCCCEEC----		2.72-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of RHO5_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of RHO5_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of RHO5_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
TRXB1_YEASTTRR1physical
11805837
RGD2_YEASTRGD2physical
11591390
STE50_YEASTSTE50physical
18621925
MSI1_YEASTMSI1genetic
18621925
RGD2_YEASTRGD2genetic
18621925
NPR1_YEASTNPR1genetic
18621925
BUD31_YEASTBUD31genetic
27708008
ELP2_YEASTELP2genetic
27708008
MPC2_YEASTMPC2genetic
27708008
RL40A_YEASTRPL40Bgenetic
27708008
RL40B_YEASTRPL40Bgenetic
27708008
BUD6_YEASTBUD6genetic
27708008
ROM2_YEASTROM2genetic
27708008
ATP10_YEASTATP10genetic
27708008
MGR3_YEASTMGR3genetic
27708008
NDH1_YEASTNDE1genetic
27708008
OST3_YEASTOST3genetic
27708008
FABD_YEASTMCT1genetic
27708008
ALDH6_YEASTALD6genetic
27708008
RTC6_YEASTRTC6genetic
27708008
YME1_YEASTYME1genetic
27708008
MED1_YEASTMED1genetic
27708008
IRA1_YEASTIRA1genetic
27811238
HOG1_YEASTHOG1genetic
29215176
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of RHO5_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-69 AND SER-223, AND MASSSPECTROMETRY.
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-66; SER-68 AND SER-75,AND MASS SPECTROMETRY.
"Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae.";
Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.;
J. Proteome Res. 6:1190-1197(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-223, AND MASSSPECTROMETRY.

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