TRXB1_YEAST - dbPTM
TRXB1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID TRXB1_YEAST
UniProt AC P29509
Protein Name Thioredoxin reductase 1
Gene Name TRR1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 319
Subcellular Localization Cytoplasm. Mitochondrion intermembrane space .
Protein Description Acts on thioredoxins 1 and 2..
Protein Sequence MVHNKVTIIGSGPAAHTAAIYLARAEIKPILYEGMMANGIAAGGQLTTTTEIENFPGFPDGLTGSELMDRMREQSTKFGTEIITETVSKVDLSSKPFKLWTEFNEDAEPVTTDAIILATGASAKRMHLPGEETYWQKGISACAVCDGAVPIFRNKPLAVIGGGDSACEEAQFLTKYGSKVFMLVRKDHLRASTIMQKRAEKNEKIEILYNTVALEAKGDGKLLNALRIKNTKKNEETDLPVSGLFYAIGHTPATKIVAGQVDTDEAGYIKTVPGSSLTSVPGFFAAGDVQDSKYRQAITSAGSGCMAALDAEKYLTSLE
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
7Phosphorylation-MVHNKVTIIGSGPA
-CCCCEEEEECCCHH		14.4222369663
11PhosphorylationNKVTIIGSGPAAHTA
CEEEEECCCHHHHHH		31.0622369663
17PhosphorylationGSGPAAHTAAIYLAR
CCCHHHHHHHHHHHH		17.0422369663
21PhosphorylationAAHTAAIYLARAEIK
HHHHHHHHHHHHHCH		6.9222369663
75PhosphorylationMDRMREQSTKFGTEI
HHHHHHHHHHHCHHH		28.8930377154
77UbiquitinationRMREQSTKFGTEIIT
HHHHHHHHHCHHHHH		47.2223749301
80PhosphorylationEQSTKFGTEIITETV
HHHHHHCHHHHHEEC		27.4330377154
84PhosphorylationKFGTEIITETVSKVD
HHCHHHHHEECCCCC		31.1224961812
86PhosphorylationGTEIITETVSKVDLS
CHHHHHEECCCCCCC		22.7922369663
88PhosphorylationEIITETVSKVDLSSK
HHHHEECCCCCCCCC		34.0922369663
94PhosphorylationVSKVDLSSKPFKLWT
CCCCCCCCCCCEEEE		52.2028889911
95SuccinylationSKVDLSSKPFKLWTE
CCCCCCCCCCEEEEC		51.6123954790
95AcetylationSKVDLSSKPFKLWTE
CCCCCCCCCCEEEEC		51.6124489116
140PhosphorylationTYWQKGISACAVCDG
HHHHCCCCHHHHCCC		26.4321440633
165PhosphorylationAVIGGGDSACEEAQF
EEECCCHHHHHHHHH		37.7927017623
175AcetylationEEAQFLTKYGSKVFM
HHHHHHHHHCCEEEE		50.1624489116
179AcetylationFLTKYGSKVFMLVRK
HHHHHCCEEEEEEEC		34.8224489116
179UbiquitinationFLTKYGSKVFMLVRK
HHHHHCCEEEEEEEC		34.8223749301
193PhosphorylationKDHLRASTIMQKRAE
CCHHHHHHHHHHHHH		21.3425752575
221AcetylationLEAKGDGKLLNALRI
EEECCCCCCHHEEEE		55.3224489116
237PhosphorylationNTKKNEETDLPVSGL
CCCCCCCCCCCCCCH		36.3421082442
246PhosphorylationLPVSGLFYAIGHTPA
CCCCCHHHHCCCCCC		11.4428889911
251PhosphorylationLFYAIGHTPATKIVA
HHHHCCCCCCCEEEE		14.9222369663
254PhosphorylationAIGHTPATKIVAGQV
HCCCCCCCEEEEECC		23.6222369663
275PhosphorylationYIKTVPGSSLTSVPG
EEEECCCCCCCCCCC		18.9921440633
276PhosphorylationIKTVPGSSLTSVPGF
EEECCCCCCCCCCCE		41.4030377154
279PhosphorylationVPGSSLTSVPGFFAA
CCCCCCCCCCCEEEC		31.4428889911
292PhosphorylationAAGDVQDSKYRQAIT
ECCCCCCHHHHHHHH		17.9421551504
293AcetylationAGDVQDSKYRQAITS
CCCCCCHHHHHHHHH		53.3824489116
293UbiquitinationAGDVQDSKYRQAITS
CCCCCCHHHHHHHHH		53.3823749301
300PhosphorylationKYRQAITSAGSGCMA
HHHHHHHHCCCCHHH		25.2321440633
303PhosphorylationQAITSAGSGCMAALD
HHHHHCCCCHHHHHH		28.6520235561
313UbiquitinationMAALDAEKYLTSLE-
HHHHHHHHHHHCCC-		47.4823749301
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of TRXB1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of TRXB1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of TRXB1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
GSHR_YEASTGLR1genetic
12376468
TRXB2_YEASTTRR2physical
16554755
TSA1_YEASTTSA1genetic
18271751
TRX2_YEASTTRX2physical
18719252
TRXB1_YEASTTRR1physical
18930846
TRX3_YEASTTRX3physical
18930846
TRXB2_YEASTTRR2genetic
15701801
TRXB2_YEASTTRR2physical
20826334
ACON2_YEASTACO2genetic
21623372
ATP5E_YEASTATP15genetic
21623372
ADE_YEASTAAH1genetic
21623372
TPS2_YEASTTPS2genetic
21623372
ADK_YEASTADO1genetic
21623372
GUP1_YEASTGUP1genetic
21623372
AATC_YEASTAAT2genetic
21623372
IAH1_YEASTIAH1genetic
21623372
SERA_YEASTSER3genetic
21623372
DCOR_YEASTSPE1genetic
21623372
CEM1_YEASTCEM1genetic
21623372
AATM_YEASTAAT1genetic
21623372
CYS3_YEASTCYS3genetic
21623372
ADH3_YEASTADH3genetic
21623372
MTAP_YEASTMEU1genetic
21623372
AP1_YEASTYAP1physical
19106090
TRX1_YEASTTRX1genetic
22561702
TRX2_YEASTTRX2genetic
22561702
TRX1_YEASTTRX1genetic
25247923
TRX2_YEASTTRX2genetic
25247923
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of TRXB1_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-11; SER-94; THR-193;SER-279; SER-300 AND SER-303, AND MASS SPECTROMETRY.

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