SERA_YEAST - dbPTM
SERA_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SERA_YEAST
UniProt AC P40054
Protein Name D-3-phosphoglycerate dehydrogenase 1
Gene Name SER3
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 469
Subcellular Localization
Protein Description Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate..
Protein Sequence MTSIDINNLQNTFQQAMNMSGSPGAVCTSPTQSFMNTVPQRLNAVKHPKILKPFSTGDMKILLLENVNQTAITIFEEQGYQVEFYKSSLPEEELIEKIKDVHAIGIRSKTRLTSNVLQHAKNLVCIGCFCIGTNQVDLDYATSRGIAVFNSPFSNSRSVAELVIAEIISLARQLGDRSIELHTGTWNKVAARCWEVRGKTLGIIGYGHIGSQLSVLAEAMGLHVLYYDIVTIMALGTARQVSTLDELLNKSDFVTLHVPATPETEKMLSAPQFAAMKDGAYVINASRGTVVDIPSLIQAVKANKIAGAALDVYPHEPAKNGEGSFNDELNSWTSELVSLPNIILTPHIGGSTEEAQSSIGIEVATALSKYINEGNSVGSVNFPEVALKSLSYDQENTVRVLYIHQNVPGVLKTVNDILSNHNIEKQFSDSNGEIAYLMADISSVDQSDIKDIYEQLNQTSAKISIRLLY
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Phosphorylation------MTSIDINNL
------CCCEEHHHH		34.1030377154
12PhosphorylationDINNLQNTFQQAMNM
EHHHHHHHHHHHHHC		15.1730377154
20PhosphorylationFQQAMNMSGSPGAVC
HHHHHHCCCCCCCEE		30.9928889911
22PhosphorylationQAMNMSGSPGAVCTS
HHHHCCCCCCCEECC		16.9228889911
29PhosphorylationSPGAVCTSPTQSFMN
CCCCEECCCCHHHHH		22.3328889911
33PhosphorylationVCTSPTQSFMNTVPQ
EECCCCHHHHHCHHH		29.0130377154
46AcetylationPQRLNAVKHPKILKP
HHHHHCCCCCCCCCC		52.3525381059
52AcetylationVKHPKILKPFSTGDM
CCCCCCCCCCCCCCE		47.7122865919
55PhosphorylationPKILKPFSTGDMKIL
CCCCCCCCCCCEEEE		39.7519823750
56PhosphorylationKILKPFSTGDMKILL
CCCCCCCCCCEEEEE		37.2619823750
97AcetylationPEEELIEKIKDVHAI
CHHHHHHHHHHHHHC		48.3222865919
99AcetylationEELIEKIKDVHAIGI
HHHHHHHHHHHHCCC		65.8422865919
121UbiquitinationSNVLQHAKNLVCIGC
HHHHHHHHCEEEEEE		49.0017644757
188UbiquitinationLHTGTWNKVAARCWE
EECCCHHHHHHHHHE		25.4717644757
188AcetylationLHTGTWNKVAARCWE
EECCCHHHHHHHHHE		25.4724489116
242PhosphorylationLGTARQVSTLDELLN
HCCHHCCCCHHHHHC		18.2128889911
243PhosphorylationGTARQVSTLDELLNK
CCHHCCCCHHHHHCC		39.1030377154
250AcetylationTLDELLNKSDFVTLH
CHHHHHCCCCCEEEE		51.9124489116
250UbiquitinationTLDELLNKSDFVTLH
CHHHHHCCCCCEEEE		51.9124961812
261PhosphorylationVTLHVPATPETEKML
EEEECCCCHHHHHHH		18.6522369663
264PhosphorylationHVPATPETEKMLSAP
ECCCCHHHHHHHCCH		41.9522369663
369UbiquitinationEVATALSKYINEGNS
HHHHHHHHHHHCCCC		51.5017644757
388UbiquitinationNFPEVALKSLSYDQE
CCHHHHHHHCCCCCC		39.3417644757
412UbiquitinationQNVPGVLKTVNDILS
CCCCCHHHHHHHHHH		48.2817644757
413PhosphorylationNVPGVLKTVNDILSN
CCCCHHHHHHHHHHC		22.0019823750
419PhosphorylationKTVNDILSNHNIEKQ
HHHHHHHHCCCHHHH		36.0619823750
425UbiquitinationLSNHNIEKQFSDSNG
HHCCCHHHHCCCCCC		53.5017644757
428PhosphorylationHNIEKQFSDSNGEIA
CCHHHHCCCCCCCEE		37.3222369663
430PhosphorylationIEKQFSDSNGEIAYL
HHHHCCCCCCCEEEE		45.6022369663
436PhosphorylationDSNGEIAYLMADISS
CCCCCEEEEEEECCC		11.5922369663
442PhosphorylationAYLMADISSVDQSDI
EEEEEECCCCCHHHH		25.5122369663
443PhosphorylationYLMADISSVDQSDIK
EEEEECCCCCHHHHH		30.0122369663
447PhosphorylationDISSVDQSDIKDIYE
ECCCCCHHHHHHHHH		36.5222369663
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SERA_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SERA_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SERA_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
PPAC_YEASTPHO12physical
11805826
SER33_YEASTSER33physical
11805826
SER33_YEASTSER33genetic
12525494
SER33_YEASTSER33physical
16554755
BDH1_YEASTBDH1physical
11283351
CST26_YEASTCST26physical
11283351
CNS1_YEASTCNS1physical
11283351
FADH_YEASTSFA1physical
11283351
MAF1_YEASTMAF1physical
11283351
TMS1_YEASTTMS1physical
11283351
NUP42_YEASTNUP42physical
11283351
MS116_YEASTMSS116physical
11283351
SERA_YEASTSER3physical
11283351
YN12B_YEASTYNL054W-Bphysical
11283351
NSL1_YEASTNSL1physical
11283351
SERA_YEASTSER3physical
18719252
SER33_YEASTSER33genetic
18408719
SER33_YEASTSER33genetic
16941010
RQC2_YEASTTAE2genetic
20691087
SER33_YEASTSER33genetic
21623372
QCR1_YEASTCOR1genetic
21623372
SER33_YEASTSER33genetic
26774271
SGPL_YEASTDPL1genetic
27708008
TGS1_YEASTTGS1genetic
27708008
SIF2_YEASTSIF2genetic
27708008
SNT1_YEASTSNT1genetic
27708008
SLX5_YEASTSLX5genetic
27708008
MTU1_YEASTSLM3genetic
27708008
MAF1_YEASTMAF1genetic
27708008
RRP8_YEASTRRP8genetic
27708008
ARX1_YEASTARX1genetic
27708008
ODO2_YEASTKGD2genetic
27708008
SA155_YEASTSAP155genetic
27708008
TRS65_YEASTTRS65genetic
27708008
TBP7_YEASTYTA7genetic
27708008
SMF2_YEASTSMF2genetic
27708008
SER33_YEASTSER33genetic
27708008
MPH1_YEASTMPH1genetic
27708008
PHO86_YEASTPHO86genetic
27708008
CBF1_YEASTCBF1genetic
27708008
MKS1_YEASTMKS1genetic
27708008
THI21_YEASTTHI21genetic
27708008
KAR3_YEASTKAR3genetic
27708008
HPA2_YEASTHPA2genetic
27708008
RL36A_YEASTRPL36Agenetic
29158977
DOM34_YEASTDOM34genetic
29158977
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SERA_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-20; SER-22 AND SER-29,AND MASS SPECTROMETRY.

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