CNS1_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CNS1_YEAST
• UniProt AC: P33313
• Protein Name: Hsp70/Hsp90 co-chaperone CNS1
• Gene Name: CNS1
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 385
• Subcellular Localization: Cytoplasm .
• Protein Description: Co-chaperone that binds to the molecular chaperones Hsp90 (HSC82 and HSP82) and Hsp70 (SSA1). Stimulates SSA1 ATPase activity, but not Hsp90 ATPase activity. Involved in only a subset of Hsp90 functions..
• Protein Sequence: MSSVNANGGYTKPQKYVPGPGDPELPPQLSEFKDKTSDEILKEMNRMPFFMTKLDETDGAGGENVELEALKALAYEGEPHEIAENFKKQGNELYKAKRFKDARELYSKGLAVECEDKSINESLYANRAACELELKNYRRCIEDCSKALTINPKNVKCYYRTSKAFFQLNKLEEAKSAATFANQRIDPENKSILNMLSVIDRKEQELKAKEEKQQREAQERENKKIMLESAMTLRNITNIKTHSPVELLNEGKIRLEDPMDFESQLIYPALIMYPTQDEFDFVGEVSELTTVQELVDLVLEGPQERFKKEGKENFTPKKVLVFMETKAGGLIKAGKKLTFHDILKKESPDVPLFDNALKIYIVPKVESEGWISKWDKQKALERRSV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSSVNANGG ------CCCCCCCCC	42.89	22369663
3	Phosphorylation	-----MSSVNANGGY -----CCCCCCCCCC	20.35	22369663
11	Phosphorylation	VNANGGYTKPQKYVP CCCCCCCCCCCCCCC	39.25	30377154
36	Phosphorylation	LSEFKDKTSDEILKE HHHCCCCCHHHHHHH	52.09	30377154
42	Acetylation	KTSDEILKEMNRMPF CCHHHHHHHHHCCCC	61.65	24489116
53	Ubiquitination	RMPFFMTKLDETDGA CCCCEEEECCCCCCC	42.00	24961812
57	Phosphorylation	FMTKLDETDGAGGEN EEEECCCCCCCCCCC	39.12	24961812
87	Acetylation	HEIAENFKKQGNELY HHHHHHHHHHCCHHH	56.63	24489116
135	Acetylation	AACELELKNYRRCIE HHHHHHHHHHHHHHH	42.42	24489116
163	Acetylation	KCYYRTSKAFFQLNK EEEEEECHHHHHHHC	48.91	24489116
170	Acetylation	KAFFQLNKLEEAKSA HHHHHHHCHHHHHHH	66.90	24489116
191	Phosphorylation	RIDPENKSILNMLSV CCCHHHHHHHHHHHH	43.84	27017623
232	Phosphorylation	IMLESAMTLRNITNI HHHHHHHHHHCCCCC	23.45	30377154
338	Phosphorylation	IKAGKKLTFHDILKK HHCCCEEEHHHHHHC	28.01	22369663
360	Phosphorylation	FDNALKIYIVPKVES CCCCEEEEEEECCCC	8.35	27017623
364	Acetylation	LKIYIVPKVESEGWI EEEEEEECCCCCCCC	47.98	24489116
367	Phosphorylation	YIVPKVESEGWISKW EEEECCCCCCCCCHH	44.38	27214570
372	Phosphorylation	VESEGWISKWDKQKA CCCCCCCCHHHHHHH	22.61	27017623

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CNS1_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CNS1_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CNS1_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HGH1_YEAST	HGH1	physical	11805826
FHP_YEAST	YHB1	physical	11805837
ILV5_YEAST	ILV5	physical	11805837
HSP7E_YEAST	ECM10	physical	11805837
STP1_YEAST	STP1	physical	10688190
HS104_YEAST	HSP104	physical	11604493
HSP82_YEAST	HSP82	physical	12788914
CYP7_YEAST	CPR7	physical	12788914
HSC82_YEAST	HSC82	physical	9819421
CYP7_YEAST	CPR7	genetic	12788914
GEA1_YEAST	GEA1	physical	16554755
NAP1_YEAST	NAP1	physical	16554755
HSC82_YEAST	HSC82	physical	16554755
SSB2_YEAST	SSB2	physical	16554755
NDC80_YEAST	NDC80	physical	15633294
ADR1_YEAST	ADR1	physical	15633294
TAF1_YEAST	TAF1	physical	15633294
HGH1_YEAST	HGH1	physical	18467557
HGH1_YEAST	HGH1	physical	22615397
CYP7_YEAST	CPR7	genetic	24923785
PPID_YEAST	CPR6	genetic	24923785
PPID_YEAST	CPR6	genetic	25380751
HSP82_YEAST	HSP82	physical	25380751
RSSA1_YEAST	RPS0A	physical	25380751

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.