SLY41_YEAST - dbPTM
SLY41_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SLY41_YEAST
UniProt AC P22215
Protein Name Uncharacterized transporter SLY41
Gene Name SLY41
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 453
Subcellular Localization Membrane
Multi-pass membrane protein.
Protein Description Able to suppress the functional loss of YPT1. May form a channel. Protein SLY41 is not essential for cell viability. The SLY41 gene is a multicopy suppressor..
Protein Sequence MIQTQSTAIKRRNSVHKNLFDPSLYQIPEPPRGGFQHQKKEYSKETFSNQVFGYDITSLKKRFTQLFPSNIQGYLPEVDLRITIICSIWYVTSSISSNLSKAILRTFNHPIALTELQFLVSAVLCVGFASIVNLFRLPRLKHTKFSKALNSFPDGILPEYLDGNFRSSILHKFLVPSKLVLMTTFPMGIFQFIGHITSHKAVSMIPVSLVHSVKALSPIITVGYYKFFEHRYYNSMTYYTLLLLIFGVMTTCWSTHGSKRASDNKSGSSLIGLLFAFISMIIFVAQNIFAKNILTIRRKVGILPSSSTDDVTSKEGQPSLDKTRFSPLQVDKITILFYCSCIGFSLTLLPFLTGELMHGGSVINDLTLETVALVAIHGIAHFFQAMLAFQLIGLLSSINYSVANIMKRIVVISVALFWETKLNFFQVFGVILTIAGLYGYDKWGLSKKDGRQA
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
4Phosphorylation----MIQTQSTAIKR
----CCCCHHHHHHH		17.3519823750
6Phosphorylation--MIQTQSTAIKRRN
--CCCCHHHHHHHHH		24.1619823750
7Phosphorylation-MIQTQSTAIKRRNS
-CCCCHHHHHHHHHC		23.6819823750
14PhosphorylationTAIKRRNSVHKNLFD
HHHHHHHCCCCCCCC		24.6419823750
42PhosphorylationFQHQKKEYSKETFSN
CCCCCCCCCHHHHHH		33.6430377154
43PhosphorylationQHQKKEYSKETFSNQ
CCCCCCCCHHHHHHC		25.7130377154
46PhosphorylationKKEYSKETFSNQVFG
CCCCCHHHHHHCCCC		35.7830377154
48PhosphorylationEYSKETFSNQVFGYD
CCCHHHHHHCCCCCC		33.5030377154
57PhosphorylationQVFGYDITSLKKRFT
CCCCCCHHHHHHHHH		25.7130377154
58PhosphorylationVFGYDITSLKKRFTQ
CCCCCHHHHHHHHHH		38.2330377154
305PhosphorylationRKVGILPSSSTDDVT
HHHCCCCCCCCCCCC		33.2117330950
306PhosphorylationKVGILPSSSTDDVTS
HHCCCCCCCCCCCCC		35.0025521595
307PhosphorylationVGILPSSSTDDVTSK
HCCCCCCCCCCCCCC		39.9522369663
308PhosphorylationGILPSSSTDDVTSKE
CCCCCCCCCCCCCCC		37.8622369663
312PhosphorylationSSSTDDVTSKEGQPS
CCCCCCCCCCCCCCC		40.8719823750
313PhosphorylationSSTDDVTSKEGQPSL
CCCCCCCCCCCCCCC		28.6726447709
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SLY41_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SLY41_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SLY41_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
UBX7_YEASTUBX7genetic
16269340
VTC4_YEASTVTC4genetic
16269340
SEC63_YEASTSEC63genetic
16269340
CHO2_YEASTCHO2genetic
16269340
RTN1_YEASTRTN1genetic
16269340
ARF1_YEASTARF1genetic
16269340
STE50_YEASTSTE50genetic
20093466
RS17B_YEASTRPS17Bgenetic
20093466
HFM1_YEASTHFM1genetic
20093466
VAM7_YEASTVAM7genetic
20093466
RME1_YEASTRME1genetic
20093466
PHB2_YEASTPHB2genetic
20093466
DHOM_YEASTHOM6genetic
20093466
SAC1_YEASTSAC1genetic
20093466
VPS24_YEASTVPS24genetic
20093466
PFD6_YEASTYKE2genetic
20093466
BCH1_YEASTBCH1genetic
20093466
GGPPS_YEASTBTS1genetic
20093466
YP089_YEASTYPR089Wgenetic
20093466
CDC1_YEASTCDC1genetic
27708008
DMA2_YEASTDMA2genetic
27708008
SYT1_YEASTSYT1genetic
27708008
TRS20_YEASTTRS20genetic
27708008
APC11_YEASTAPC11genetic
27708008
MPS1_YEASTMPS1genetic
27708008
TRS23_YEASTTRS23genetic
27708008
ACT_YEASTACT1genetic
27708008
KTHY_YEASTCDC8genetic
27708008
BET3_YEASTBET3genetic
27708008
DCP2_YEASTDCP2genetic
27708008
ARP7_YEASTARP7genetic
27708008
STE50_YEASTSTE50genetic
27708008
ELO2_YEASTELO2genetic
27708008
RS17B_YEASTRPS17Bgenetic
27708008
YFL5_YEASTYFR045Wgenetic
27708008
VAM7_YEASTVAM7genetic
27708008
RME1_YEASTRME1genetic
27708008
ASK10_YEASTASK10genetic
27708008
PHB2_YEASTPHB2genetic
27708008
MGA2_YEASTMGA2genetic
27708008
DHOM_YEASTHOM6genetic
27708008
SAC1_YEASTSAC1genetic
27708008
PFD6_YEASTYKE2genetic
27708008
HPF1_YEASTHPF1genetic
27708008
GGPPS_YEASTBTS1genetic
27708008
YP089_YEASTYPR089Wgenetic
27708008
ATC1_YEASTPMR1genetic
27030673
SC23B_HUMANSEC23Bphysical
27107014
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SLY41_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-305; SER-306; SER-307AND THR-308, AND MASS SPECTROMETRY.
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-305; SER-306 ANDSER-307, AND MASS SPECTROMETRY.

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