VTC4_YEAST - dbPTM
VTC4_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID VTC4_YEAST
UniProt AC P47075
Protein Name Vacuolar transporter chaperone 4
Gene Name VTC4
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 721
Subcellular Localization Vacuole membrane
Multi-pass membrane protein .
Protein Description Component of the vacuolar transporter chaperone (VTC) complex, which plays a role in vacuolar membrane fusion. [PubMed: 12584253]
Protein Sequence MKFGEHLSKSLIRQYSYYYISYDDLKTELEDNLSKNNGQWTQELETDFLESLEIELDKVYTFCKVKHSEVFRRVKEVQEQVQHTVRLLDSNNPPTQLDFEILEEELSDIIADVHDLAKFSRLNYTGFQKIIKKHDKKTGFILKPVFQVRLDSKPFFKENYDELVVKISQLYDIARTSGRPIKGDSSAGGKQQNFVRQTTKYWVHPDNITELKLIILKHLPVLVFNTNKEFEREDSAITSIYFDNENLDLYYGRLRKDEGAEAHRLRWYGGMSTDTIFVERKTHREDWTGEKSVKARFALKERHVNDFLKGKYTVDQVFAKMRKEGKKPMNEIENLEALASEIQYVMLKKKLRPVVRSFYNRTAFQLPGDARVRISLDTELTMVREDNFDGVDRTHKNWRRTDIGVDWPFKQLDDKDICRFPYAVLEVKLQTQLGQEPPEWVRELVGSHLVEPVPKFSKFIHGVATLLNDKVDSIPFWLPQMDVDIRKPPLPTNIEITRPGRSDNEDNDFDEDDEDDAALVAAMTNAPGNSLDIEESVGYGATSAPTSNTNHVVESANAAYYQRKIRNAENPISKKYYEIVAFFDHYFNGDQISKIPKGTTFDTQIRAPPGKTICVPVRVEPKVYFATERTYLSWLSISILLGGVSTTLLTYGSPTAMIGSIGFFITSLAVLIRTVMVYAKRVVNIRLKRAVDYEDKIGPGMVSVFLILSILFSFFCNLVAK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Ubiquitination------MKFGEHLSK
------CCHHHHHHH		63.1817644757
9UbiquitinationKFGEHLSKSLIRQYS
CHHHHHHHHHHHHHC		56.4917644757
16PhosphorylationKSLIRQYSYYYISYD
HHHHHHHCEEEEEHH		9.7928889911
17PhosphorylationSLIRQYSYYYISYDD
HHHHHHCEEEEEHHH		8.7130377154
22PhosphorylationYSYYYISYDDLKTEL
HCEEEEEHHHHHHHH		12.1530377154
26UbiquitinationYISYDDLKTELEDNL
EEEHHHHHHHHHHHH		47.1217644757
35UbiquitinationELEDNLSKNNGQWTQ
HHHHHHHHCCCCEEH		58.5617644757
58UbiquitinationSLEIELDKVYTFCKV
HCEEEHHEEEEECCC		50.1715699485
64AcetylationDKVYTFCKVKHSEVF
HEEEEECCCCHHHHH		50.5622865919
64UbiquitinationDKVYTFCKVKHSEVF
HEEEEECCCCHHHHH		50.5615699485
662-HydroxyisobutyrylationVYTFCKVKHSEVFRR
EEEECCCCHHHHHHH		27.23-
75UbiquitinationSEVFRRVKEVQEQVQ
HHHHHHHHHHHHHHH		50.8123749301
118UbiquitinationADVHDLAKFSRLNYT
HHHHHHHHHHCCCCC		51.6917644757
129UbiquitinationLNYTGFQKIIKKHDK
CCCCCHHHHHHHCCC		44.1022817900
129AcetylationLNYTGFQKIIKKHDK
CCCCCHHHHHHHCCC		44.1024489116
132UbiquitinationTGFQKIIKKHDKKTG
CCHHHHHHHCCCCCC		47.7522817900
133UbiquitinationGFQKIIKKHDKKTGF
CHHHHHHHCCCCCCE		46.7822817900
137AcetylationIIKKHDKKTGFILKP
HHHHCCCCCCEEEEE		61.0022865919
137UbiquitinationIIKKHDKKTGFILKP
HHHHCCCCCCEEEEE		61.0017644757
143AcetylationKKTGFILKPVFQVRL
CCCCEEEEEEEEEEE		34.0324489116
143UbiquitinationKKTGFILKPVFQVRL
CCCCEEEEEEEEEEE		34.0317644757
153AcetylationFQVRLDSKPFFKENY
EEEEECCCCCCCCCH		45.5724489116
153UbiquitinationFQVRLDSKPFFKENY
EEEEECCCCCCCCCH		45.5722817900
157UbiquitinationLDSKPFFKENYDELV
ECCCCCCCCCHHHHH		45.4922817900
157AcetylationLDSKPFFKENYDELV
ECCCCCCCCCHHHHH		45.4924489116
166UbiquitinationNYDELVVKISQLYDI
CHHHHHHHHHHHHHH		29.2117644757
182UbiquitinationRTSGRPIKGDSSAGG
HHCCCCCCCCCCCCC		60.3922817900
190UbiquitinationGDSSAGGKQQNFVRQ
CCCCCCCCCHHHEEE		48.0323749301
190AcetylationGDSSAGGKQQNFVRQ
CCCCCCCCCHHHEEE		48.0325381059
200AcetylationNFVRQTTKYWVHPDN
HHEEECCEEEECCCC		40.2724489116
200UbiquitinationNFVRQTTKYWVHPDN
HHEEECCEEEECCCC		40.2722817900
212UbiquitinationPDNITELKLIILKHL
CCCCCHHHHHHHHCC		31.2617644757
256AcetylationLYYGRLRKDEGAEAH
EEEEEEECCCCHHHH		65.8022865919
281UbiquitinationDTIFVERKTHREDWT
CEEEEEECCCCCCCC		34.8717644757
291UbiquitinationREDWTGEKSVKARFA
CCCCCCCCCHHHHHH		62.9917644757
3002-HydroxyisobutyrylationVKARFALKERHVNDF
HHHHHHHHHHHHHHH		49.63-
300UbiquitinationVKARFALKERHVNDF
HHHHHHHHHHHHHHH		49.6317644757
309AcetylationRHVNDFLKGKYTVDQ
HHHHHHHCCCCCHHH		54.0422865919
309UbiquitinationRHVNDFLKGKYTVDQ
HHHHHHHCCCCCHHH		54.0417644757
311UbiquitinationVNDFLKGKYTVDQVF
HHHHHCCCCCHHHHH		35.8417644757
311AcetylationVNDFLKGKYTVDQVF
HHHHHCCCCCHHHHH		35.8424489116
320UbiquitinationTVDQVFAKMRKEGKK
CHHHHHHHHHHCCCC		27.9817644757
320AcetylationTVDQVFAKMRKEGKK
CHHHHHHHHHHCCCC		27.9824489116
323UbiquitinationQVFAKMRKEGKKPMN
HHHHHHHHCCCCCHH		68.2822817900
326UbiquitinationAKMRKEGKKPMNEIE
HHHHHCCCCCHHHHH		55.5922817900
327UbiquitinationKMRKEGKKPMNEIEN
HHHHCCCCCHHHHHH		61.4322817900
344PhosphorylationALASEIQYVMLKKKL
HHHHHHHHHHHHHCH		8.0927017623
348UbiquitinationEIQYVMLKKKLRPVV
HHHHHHHHHCHHHHH		29.7515699485
349UbiquitinationIQYVMLKKKLRPVVR
HHHHHHHHCHHHHHH		53.7515699485
410UbiquitinationIGVDWPFKQLDDKDI
CCCCCCCCCCCCCCC		45.9624961812
428UbiquitinationPYAVLEVKLQTQLGQ
CEEEEEHHHHHCCCC		26.0417644757
455UbiquitinationHLVEPVPKFSKFIHG
HCCCCCHHHHHHHHH		63.6017644757
455AcetylationHLVEPVPKFSKFIHG
HCCCCCHHHHHHHHH		63.6024489116
458AcetylationEPVPKFSKFIHGVAT
CCCHHHHHHHHHHHH		52.0124489116
574UbiquitinationNAENPISKKYYEIVA
CCCCCCCHHHHHHHE		45.5817644757
575UbiquitinationAENPISKKYYEIVAF
CCCCCCHHHHHHHEE		46.4017644757
594UbiquitinationFNGDQISKIPKGTTF
CCCCHHCCCCCCCCC		65.7317644757
597UbiquitinationDQISKIPKGTTFDTQ
CHHCCCCCCCCCCCE		72.8123749301
600PhosphorylationSKIPKGTTFDTQIRA
CCCCCCCCCCCEEEC		28.3428889911
611UbiquitinationQIRAPPGKTICVPVR
EEECCCCCEEEEEEE		40.2523749301
622UbiquitinationVPVRVEPKVYFATER
EEEEECCEEEEECCH		35.7417644757
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of VTC4_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of VTC4_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of VTC4_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SLY41_YEASTSLY41genetic
16269340
GDA1_YEASTGDA1genetic
16269340
PHO88_YEASTPHO88physical
16093310
PFA5_YEASTPFA5physical
16093310
GUP1_YEASTGUP1physical
16093310
HIP1_YEASTHIP1physical
16093310
HXT1_YEASTHXT1physical
16093310
PMT4_YEASTPMT4physical
16093310
DAL5_YEASTDAL5physical
16093310
GSF2_YEASTGSF2physical
16093310
PHO80_YEASTPHO80genetic
19325107
ATC1_YEASTPMR1genetic
19325107
ELO3_YEASTELO3genetic
19325107
UBX2_YEASTUBX2genetic
19325107
VPS9_YEASTVPS9genetic
19325107
OS9_YEASTYOS9genetic
19325107
DGK1_YEASTDGK1genetic
27708008
SWC5_YEASTSWC5genetic
27708008
RMD9L_YEASTYBR238Cgenetic
27708008
CHK1_YEASTCHK1genetic
27708008
ATG15_YEASTATG15genetic
27708008
RLA1_YEASTRPP1Agenetic
27708008
IPK1_YEASTIPK1genetic
27708008
TFS2_YEASTDST1genetic
27708008
GTR2_YEASTGTR2genetic
27708008
MBR1_YEASTMBR1genetic
27708008
FPS1_YEASTFPS1genetic
27708008
SIC1_YEASTSIC1genetic
27708008
VPS9_YEASTVPS9genetic
27708008
ZRC1_YEASTZRC1genetic
27708008
ELP6_YEASTELP6genetic
27708008
RAS2_YEASTRAS2genetic
27708008
YO223_YEASTDSC3genetic
27708008
GDS1_YEASTGDS1genetic
27708008
ELP3_YEASTELP3genetic
27708008
PNG1_YEASTPNG1genetic
27708008
H1_YEASTHHO1genetic
27708008
BEM4_YEASTBEM4genetic
27708008
YD089_YEASTYDR089Wphysical
27587415
VTC3_YEASTVTC3physical
27587415
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of VTC4_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-16 AND THR-600, AND MASSSPECTROMETRY.

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