HIP1_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HIP1_YEAST
• UniProt AC: P06775
• Protein Name: Histidine permease
• Gene Name: HIP1
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 603
• Subcellular Localization: Membrane; Multi-pass membrane protein.
• Protein Description: High-affinity permease for histidine..
• Protein Sequence: MPRNPLKKEYWADVVDGFKPATSPAFENEKESTTFVTELTSKTDSAFPLSSKDSPGINQTTNDITSSDRFRRNEDTEQEDINNTNLSKDLSVRHLLTLAVGGAIGTGLYVNTGAALSTGGPASLVIDWVIISTCLFTVINSLGELSAAFPVVGGFNVYSMRFIEPSFAFAVNLNYLAQWLVLLPLELVAASITIKYWNDKINSDAWVAIFYATIALANMLDVKSFGETEFVLSMIKILSIIGFTILGIVLSCGGGPHGGYIGGKYWHDPGAFVGHSSGTQFKGLCSVFVTAAFSYSGIEMTAVSAAESKNPRETIPKAAKRTFWLITASYVTILTLIGCLVPSNDPRLLNGSSSVDAASSPLVIAIENGGIKGLPSLMNAIILIAVVSVANSAVYACSRCMVAMAHIGNLPKFLNRVDKRGRPMNAILLTLFFGLLSFVAASDKQAEVFTWLSALSGLSTIFCWMAINLSHIRFRQAMKVQERSLDELPFISQTGVKGSWYGFIVLFLVLIASFWTSLFPLGGSGASAESFFEGYLSFPILIVCYVGHKLYTRNWTLMVKLEDMDLDTGRKQVDLTLRREEMRIERETLAKRSFVTRFLHFWC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
19	Ubiquitination	ADVVDGFKPATSPAF HHHCCCCCCCCCCCC	38.99	23749301
22	Phosphorylation	VDGFKPATSPAFENE CCCCCCCCCCCCCCC	43.71	21440633
23	Phosphorylation	DGFKPATSPAFENEK CCCCCCCCCCCCCCC	19.14	27717283
30	Ubiquitination	SPAFENEKESTTFVT CCCCCCCCCCCEEEE	69.42	23749301
37	Phosphorylation	KESTTFVTELTSKTD CCCCEEEEECCCCCC	22.53	27017623
40	Phosphorylation	TTFVTELTSKTDSAF CEEEEECCCCCCCCC	23.19	21440633
41	Phosphorylation	TFVTELTSKTDSAFP EEEEECCCCCCCCCC	46.30	21440633
42	Ubiquitination	FVTELTSKTDSAFPL EEEECCCCCCCCCCC	51.63	23749301
45	Phosphorylation	ELTSKTDSAFPLSSK ECCCCCCCCCCCCCC	36.72	23749301
50	Phosphorylation	TDSAFPLSSKDSPGI CCCCCCCCCCCCCCC	35.26	23749301
51	Phosphorylation	DSAFPLSSKDSPGIN CCCCCCCCCCCCCCC	48.44	23749301
52	Ubiquitination	SAFPLSSKDSPGINQ CCCCCCCCCCCCCCC	59.87	23749301
54	Phosphorylation	FPLSSKDSPGINQTT CCCCCCCCCCCCCCC	28.85	17330950
60	Phosphorylation	DSPGINQTTNDITSS CCCCCCCCCCCCCCC	24.07	29688323
61	Phosphorylation	SPGINQTTNDITSSD CCCCCCCCCCCCCCC	22.56	29688323
65	Phosphorylation	NQTTNDITSSDRFRR CCCCCCCCCCCCHHC	25.66	23749301
66	Phosphorylation	QTTNDITSSDRFRRN CCCCCCCCCCCHHCC	30.49	21440633
67	Phosphorylation	TTNDITSSDRFRRNE CCCCCCCCCCHHCCC	24.93	23749301
76	Phosphorylation	RFRRNEDTEQEDINN CHHCCCCCCCHHHCC	33.13	21551504
88	Ubiquitination	INNTNLSKDLSVRHL HCCCCCCHHHCHHHH	66.89	23749301
576	Phosphorylation	GRKQVDLTLRREEMR CCEEEEHHHHHHHHH	17.47	15665377
603	S-palmitoylation	TRFLHFWC------- HHHHHHCC-------	3.80	16751107

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HIP1_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HIP1_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HIP1_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
C1TC_YEAST	ADE3	genetic	12684846
TAT1_YEAST	TAT1	genetic	9473505
SAM3_YEAST	SAM3	genetic	16269340
LHS1_YEAST	LHS1	genetic	16269340
PRA1_YEAST	YIP3	genetic	16269340
GLO3_YEAST	GLO3	genetic	16269340
CFAH_HUMAN	CFH	physical	17959597
SHR3_YEAST	SHR3	physical	16093310
MKAR_YEAST	IFA38	physical	16093310
ELO2_YEAST	ELO2	physical	16093310
STE24_YEAST	STE24	physical	16093310
ELO3_YEAST	ELO3	physical	16093310
ERP4_YEAST	ERP4	physical	16093310

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.