SAM3_YEAST - dbPTM
SAM3_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SAM3_YEAST
UniProt AC Q08986
Protein Name S-adenosylmethionine permease SAM3
Gene Name SAM3
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 587
Subcellular Localization Membrane
Multi-pass membrane protein . Endoplasmic reticulum .
Protein Description High-affinity S-adenosylmethionine permease, required for utilization of S-adenosylmethionine as a sulfur source..
Protein Sequence MDILKRGNESDKFTKIETESTTIPNDSDRSGSLIRRMKDSFKQSNLHVIPEDLENSEQTEQEKIQWKLASQPYQKVLSQRHLTMIAIGGTLGTGLFIGLGYSLASGPAALLIGFLLVGTSMFCVVQSAAELSCQFPVSGSYATHVSRFIDESVGFTVATNYALAWLISFPSELIGCALTISYWNQTVNPAVWVAIFYVFIMVLNLFGVRGFAETEFALSIIKVIAIFIFIIIGIVLIAGGGPNSTGYIGAKYWHDPGAFAKPVFKNLCNTFVSAAFSFGGSELVLLTSTESKNISAISRAAKGTFWRIAIFYITTVVIIGCLVPYNDPRLLSGSNSEDVSASPFVIALSNTGSMGAKVSNFMNVVILVAVVSVCNSCVYASSRLIQALGASGQLPSVCSYMDRKGRPLVGIGISGAFGLLGFLVASKKEDEVFTWLFALCSISSFFTWFCICMSQIRFRMALKAQGRSNDEIAYKSILGVYGGILGCVLNALLIAGEIYVSAAPVGSPSSAEAFFEYCLSIPIMIVVYFAHRFYRRDWKHFYIKRSEIDLDTGCSVENLELFKAQKEAEEQLIASKPFYYKIYRFWC
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
10PhosphorylationILKRGNESDKFTKIE
CCCCCCCCCCCCEEE		50.5321082442
12UbiquitinationKRGNESDKFTKIETE
CCCCCCCCCCEEEEE		65.3023749301
14PhosphorylationGNESDKFTKIETEST
CCCCCCCCEEEEECC		36.5328889911
15UbiquitinationNESDKFTKIETESTT
CCCCCCCEEEEECCC		41.5023749301
18PhosphorylationDKFTKIETESTTIPN
CCCCEEEEECCCCCC		38.4122890988
20PhosphorylationFTKIETESTTIPNDS
CCEEEEECCCCCCCC		37.9725533186
21PhosphorylationTKIETESTTIPNDSD
CEEEEECCCCCCCCC		23.6322890988
22PhosphorylationKIETESTTIPNDSDR
EEEEECCCCCCCCCC		43.6522890988
27PhosphorylationSTTIPNDSDRSGSLI
CCCCCCCCCCCCHHH		41.3822890988
30PhosphorylationIPNDSDRSGSLIRRM
CCCCCCCCCHHHHHH		37.4124961812
32PhosphorylationNDSDRSGSLIRRMKD
CCCCCCCHHHHHHHH		23.1321440633
42UbiquitinationRRMKDSFKQSNLHVI
HHHHHHHHHCCCCCC		57.6923749301
44PhosphorylationMKDSFKQSNLHVIPE
HHHHHHHCCCCCCCH		41.7828889911
56PhosphorylationIPEDLENSEQTEQEK
CCHHHCCCCHHHHHH		23.0021440633
59PhosphorylationDLENSEQTEQEKIQW
HHCCCCHHHHHHHHH		35.2721440633
63UbiquitinationSEQTEQEKIQWKLAS
CCHHHHHHHHHHHCC		39.6323749301
67UbiquitinationEQEKIQWKLASQPYQ
HHHHHHHHHCCCHHH		20.1423749301
67AcetylationEQEKIQWKLASQPYQ
HHHHHHHHHCCCHHH		20.1424489116
75UbiquitinationLASQPYQKVLSQRHL
HCCCHHHHHHCCCCE		39.0223749301
184N-linked_GlycosylationALTISYWNQTVNPAV
HHHHHHHCCCCCHHH		21.29-
243N-linked_GlycosylationLIAGGGPNSTGYIGA
HHCCCCCCCCCCCCC		56.32-
261AcetylationHDPGAFAKPVFKNLC
CCCCHHHHHHHHHHH		34.9524489116
399PhosphorylationGQLPSVCSYMDRKGR
CCCCHHHHHHCCCCC		22.7230377154
563UbiquitinationVENLELFKAQKEAEE
HHHHHHHHHHHHHHH		63.6323749301
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SAM3_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SAM3_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SAM3_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
BFR1_YEASTBFR1genetic
16269340
HIP1_YEASTHIP1genetic
16269340
SKT5_YEASTSKT5genetic
20093466
SDS24_YEASTSDS24genetic
20093466
SWC5_YEASTSWC5genetic
20093466
HAP2_YEASTHAP2genetic
20093466
DCOR_YEASTSPE1genetic
20093466
EOS1_YEASTEOS1genetic
20093466
PET8_YEASTPET8genetic
20093466
CY1_YEASTCYT1genetic
20093466
COQ7_YEASTCAT5genetic
20093466
SHR3_YEASTSHR3physical
16093310
PHO88_YEASTPHO88physical
16093310
ALG1_YEASTALG1physical
16093310
MKAR_YEASTIFA38physical
16093310
ELO2_YEASTELO2physical
16093310
GIT1_YEASTGIT1physical
16093310
SUR2_YEASTSUR2physical
16093310
PSS_YEASTCHO1physical
16093310
ERV29_YEASTERV29physical
16093310
NSG1_YEASTNSG1physical
16093310
SNL1_YEASTSNL1physical
16093310
VDAC2_YEASTPOR2physical
16093310
STE24_YEASTSTE24physical
16093310
SRPB_YEASTSRP102physical
16093310
GSF2_YEASTGSF2physical
16093310
FET3_YEASTFET3physical
16093310
ERP4_YEASTERP4physical
16093310
PXA1_YEASTPXA1physical
16093310
ALG5_YEASTALG5physical
16093310
ELO3_YEASTELO3genetic
21623372
DCOR_YEASTSPE1genetic
21623372
COQ4_YEASTCOQ4genetic
21623372
GGPPS_YEASTBTS1genetic
21623372
6PGD1_YEASTGND1genetic
21623372
SLX5_YEASTSLX5genetic
27708008
SDHX_YEASTYJL045Wgenetic
27708008
GPR1_YEASTGPR1genetic
27708008
VMA21_YEASTVMA21genetic
27708008
EFM4_YEASTEFM4genetic
27708008
PANC_YEASTPAN6genetic
27708008
YJH0_YEASTYJL070Cgenetic
27708008
GLG2_YEASTGLG2genetic
27708008
YJQ3_YEASTYJL163Cgenetic
27708008
MNN5_YEASTMNN5genetic
27708008
CSN12_YEASTYJR084Wgenetic
27708008
SFC1_YEASTSFC1genetic
27708008
DCOR_YEASTSPE1genetic
27708008
PET8_YEASTPET8genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SAM3_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Quantitative phosphoproteomics applied to the yeast pheromonesignaling pathway.";
Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J.,Mann M., Jensen O.N.;
Mol. Cell. Proteomics 4:310-327(2005).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-10, AND MASSSPECTROMETRY.

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