dbPTM

NSG1_YEAST - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	NSG1_YEAST
UniProt AC	P38837
Protein Name	Protein NSG1
Gene Name	NSG1
Organism	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length	291
Subcellular Localization	Endoplasmic reticulum membrane Multi-pass membrane protein .
Protein Description	Stabilizes the HMG-CoA reductase HMG2 by preventing its HRD1-dependent degradation. Binds directly to the sterol-sensing domain (SSD)-containing transmembrane region of HMG2, promoting its folding to protect it from degradation..
Protein Sequence	MGKKKSKNQLNTGGVPNGVHNTKKEAALPPLGNKLGSASFTAINTLTKPALFSFYDDDITKNEGNVYDKALLSNASQLEMVPPSATARHERSLYAKIINTIAAFFILFIAGILFPMISECLFDNDQLAKGDIVSFLKHGIEIKNKIVAEPDMVPDWAVFGTEGVIFGSIVPFIDSFVRYQHQPKTRSSVYKNTLGSFIRCANTLLGLIFGIRKLEWSSSLQAAGAWSLLNIVLWLFFDGTLTVFFPGLVIGALSAFTCSQCFSQLSLALYFIDFYFFGFLMFSKLGRYLFN

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Phosphorylation	--MGKKKSKNQLNTG --CCCCCCCCCCCCC	45.80	30377154
34	Ubiquitination	ALPPLGNKLGSASFT CCCCCCCCCCCCCEE	53.04	17644757
37	Phosphorylation	PLGNKLGSASFTAIN CCCCCCCCCCEEEHH	31.04	22369663
39	Phosphorylation	GNKLGSASFTAINTL CCCCCCCCEEEHHCC	25.48	22369663
41	Phosphorylation	KLGSASFTAINTLTK CCCCCCEEEHHCCCC	24.92	22369663
45	Phosphorylation	ASFTAINTLTKPALF CCEEEHHCCCCCCHH	29.68	22369663
47	Phosphorylation	FTAINTLTKPALFSF EEEHHCCCCCCHHCC	32.70	22369663
48	Ubiquitination	TAINTLTKPALFSFY EEHHCCCCCCHHCCC	31.26	17644757
53	Phosphorylation	LTKPALFSFYDDDIT CCCCCHHCCCCCCCC	24.60	22369663
55	Phosphorylation	KPALFSFYDDDITKN CCCHHCCCCCCCCCC	19.77	22369663
60	Phosphorylation	SFYDDDITKNEGNVY CCCCCCCCCCCCCHH	34.51	22369663
61	Ubiquitination	FYDDDITKNEGNVYD CCCCCCCCCCCCHHH	54.02	17644757
67	Phosphorylation	TKNEGNVYDKALLSN CCCCCCHHHHHHHCC	18.74	22369663
69	Ubiquitination	NEGNVYDKALLSNAS CCCCHHHHHHHCCHH	24.21	17644757
73	Phosphorylation	VYDKALLSNASQLEM HHHHHHHCCHHHCCC	31.06	30377154
76	Phosphorylation	KALLSNASQLEMVPP HHHHCCHHHCCCCCC	39.28	25752575
84	Phosphorylation	QLEMVPPSATARHER HCCCCCCCCCHHHHH	31.98	27214570
137	Acetylation	GDIVSFLKHGIEIKN CCHHHHHHHCCEECC	37.46	24489116

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of NSG1_YEAST !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of NSG1_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of NSG1_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HMDH2_YEAST	HMG2	physical	16270032
HMDH2_YEAST	HMG2	physical	18467557
ADT2_YEAST	PET9	physical	16093310
PHO88_YEAST	PHO88	physical	16093310
ALG1_YEAST	ALG1	physical	16093310
MKAR_YEAST	IFA38	physical	16093310
PHO89_YEAST	PHO89	physical	16093310
ELO2_YEAST	ELO2	physical	16093310
TECR_YEAST	TSC13	physical	16093310
FET5_YEAST	FET5	physical	16093310
ARN2_YEAST	ARN2	physical	16093310
YHU0_YEAST	YHR140W	physical	16093310
SNL1_YEAST	SNL1	physical	16093310
PHO86_YEAST	PHO86	physical	16093310
GAS2_YEAST	GAS2	physical	16093310
ELO3_YEAST	ELO3	physical	16093310
GSF2_YEAST	GSF2	physical	16093310
HMDH1_YEAST	HMG1	physical	16093310
TOM22_YEAST	TOM22	physical	16093310
PRM1_YEAST	PRM1	physical	16093310
ERP4_YEAST	ERP4	physical	16093310
ALG5_YEAST	ALG5	physical	16093310
YOP1_YEAST	YOP1	physical	16093310
KPYK1_YEAST	CDC19	physical	22940862
HSP71_YEAST	SSA1	physical	22940862
HMDH2_YEAST	HMG2	physical	23306196
ACT_YEAST	ACT1	genetic	27708008
MOB1_YEAST	MOB1	genetic	27708008
TAD3_YEAST	TAD3	genetic	27708008
KASH5_HUMAN	CCDC155	physical	27107014

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of NSG1_YEAST

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-39 AND SER-76, AND MASSSPECTROMETRY.	18407956 [Abstract]
"Quantitative phosphoproteomics applied to the yeast pheromonesignaling pathway."; Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J.,Mann M., Jensen O.N.; Mol. Cell. Proteomics 4:310-327(2005). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-39, AND MASSSPECTROMETRY.	15665377 [Abstract]