| UniProt ID | MNN5_YEAST | |
|---|---|---|
| UniProt AC | P46982 | |
| Protein Name | Alpha-1,2-mannosyltransferase MNN5 | |
| Gene Name | MNN5 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 586 | |
| Subcellular Localization | Golgi apparatus, cis-Golgi network . Golgi localization depends on SVP26. | |
| Protein Description | Responsible for addition of first and second mannose residues to the outer chain of core N-linked polysaccharides and to O-linked mannotriose. Implicated in late Golgi modifications.. | |
| Protein Sequence | MLIRLKKRKILQVIVSAVVLILFFCSVHNDVSSSWLYGKKLRLPVLTRSNLKNNFYTTLVQAIVENKPADSSPDLSKLHGAEGCSFANNVAAHDSGHDSDLSYESLSKCYNLNKTVQESLREVHSKFTDTLSGKLNFSIPQREALFSGSEGIVTIGGGKYSVLAYTMIKKLRDTGTTLPIEVIIPPQDEGEDDFCKNWLPKFNGKCIYFSDIVPSKPLSDLKLTHFQLKVFGLIISSFKRIIFLDADNYAVKNLDLAFNTTSFNDTGLILWPDFWRRVTPPAFYNIIGSSINIGKRVRFVSDDISPVSRYDPFVSNSNDYTPKERQEHFLKHVPLHDLDGTMPDLSSESGQMVIDKIRHFNTLLLALYYNVYGPTWYYKMISQGTAGEGDKDTFVAAAHALNMPYYQVRTNFEFDGFFYQKDDYKGLALLQHDFEQDYKQYQKAQQKVKANIEEFSKLDPDYTLDNGFLKTLMVNDDGSDLDIMFIHASFYKADPWTLYHENRFIGPNGEQVRGFRKPHRYGMDFELFLFNDMRGSFCTTPKSQVIKFKYFTDKVNTPEWDAMCEYLTNHVNYLESTHKEAMGEKN | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 6 | Acetylation | --MLIRLKKRKILQV --CCHHCCHHHHHHH | 40.46 | 25381059 | |
| 113 | N-linked_Glycosylation | LSKCYNLNKTVQESL HHHHHCCCHHHHHHH | 34.02 | - | |
| 126 | Acetylation | SLREVHSKFTDTLSG HHHHHHHHHHHHHCC | 37.09 | 24489116 | |
| 136 | N-linked_Glycosylation | DTLSGKLNFSIPQRE HHHCCCCCEECCCHH | 31.91 | - | |
| 259 | N-linked_Glycosylation | KNLDLAFNTTSFNDT ECCCEEEECCCCCCC | 36.52 | - | |
| 264 | N-linked_Glycosylation | AFNTTSFNDTGLILW EEECCCCCCCCEEEC | 45.78 | - | |
| 323 | Acetylation | NSNDYTPKERQEHFL CCCCCCHHHHHHHHH | 58.70 | 24489116 | |
| 439 | Acetylation | HDFEQDYKQYQKAQQ CCHHHHHHHHHHHHH | 51.31 | 24489116 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of MNN5_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of MNN5_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of MNN5_YEAST !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| ILM1_YEAST | ILM1 | genetic | 19325107 | |
| CALX_YEAST | CNE1 | genetic | 23891562 | |
| PEX22_YEAST | PEX22 | genetic | 27708008 | |
| CYPR_YEAST | CPR4 | genetic | 27708008 | |
| SLX5_YEAST | SLX5 | genetic | 27708008 | |
| YL413_YEAST | INA1 | genetic | 27708008 | |
| OCA2_YEAST | OCA2 | genetic | 27708008 | |
| DIA2_YEAST | DIA2 | genetic | 27708008 | |
| PCL8_YEAST | PCL8 | genetic | 27708008 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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