dbPTM

PGPS1_YEAST - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	PGPS1_YEAST
UniProt AC	P25578
Protein Name	CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase
Gene Name	PGS1
Organism	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length	521
Subcellular Localization	Mitochondrion .
Protein Description	Essential for the viability of mitochondrial petite mutant. Catalyzes the committed step to the synthesis of the acidic phospholipids..
Protein Sequence	MTTRLLQLTRPHYRLLSLPLQKPFNIKRQMSAANPSPFGNYLNTITKSLQQNLQTCFHFQAKEIDIIESPSQFYDLLKTKILNSQNRIFIASLYLGKSETELVDCISQALTKNPKLKVSFLLDGLRGTRELPSACSATLLSSLVAKYGSERVDCRLYKTPAYHGWKKVLVPKRFNEGLGLQHMKIYGFDNEVILSGANLSNDYFTNRQDRYYLFKSRNFSNYYFKLHQLISSFSYQIIKPMVDGSINIIWPDSNPTVEPTKNKRLFLREASQLLDGFLKSSKQSLPITAVGQFSTLVYPISQFTPLFPKYNDKSTEKRTILSLLSTITSNAISWTFTAGYFNILPDIKAKLLATPVAEANVITASPFANGFYQSKGVSSNLPGAYLYLSKKFLQDVCRYRQDHAITLREWQRGVVNKPNGWSYHAKGIWLSARDKNDANNWKPFITVIGSSNYTRRAYSLDLESNALIITRDEELRKKMKAELDNLLQYTKPVTLEDFQSDPERHVGTGVKIATSILGKKL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
159	Phosphorylation	VDCRLYKTPAYHGWK EEEEEEECCCCCCCE	10.29	28889911
508	Phosphorylation	DPERHVGTGVKIATS CHHHCCCCCHHHHHH	37.40	22890988
514	Phosphorylation	GTGVKIATSILGKKL CCCHHHHHHHHCCCC	21.55	22890988
515	Phosphorylation	TGVKIATSILGKKL- CCHHHHHHHHCCCC-	13.54	22890988

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of PGPS1_YEAST !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of PGPS1_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of PGPS1_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KRE5_YEAST	KRE5	genetic	15563612
ATH1_YEAST	ATH1	genetic	19401462
GAC1_YEAST	GAC1	genetic	19401462
GPP2_YEAST	GPP2	genetic	19401462
HSP12_YEAST	HSP12	genetic	19401462
IML3_YEAST	IML3	genetic	19401462
MRK1_YEAST	MRK1	genetic	19401462
MSN2_YEAST	MSN2	genetic	19401462
PBS2_YEAST	PBS2	genetic	19401462
PIL1_YEAST	PIL1	genetic	19401462
PSR1_YEAST	PSR1	genetic	19401462
ROM2_YEAST	ROM2	genetic	19401462
SHO1_YEAST	SHO1	genetic	19401462
SKN7_YEAST	SKN7	genetic	19401462
HSP72_YEAST	SSA2	genetic	19401462
SSK2_YEAST	SSK2	genetic	19401462
SSK22_YEAST	SSK22	genetic	19401462
STE50_YEAST	STE50	genetic	19401462
WSC3_YEAST	WSC3	genetic	19401462
WSC4_YEAST	WSC4	genetic	19401462
AP1_YEAST	YAP1	genetic	19401462
KRE5_YEAST	KRE5	genetic	19401462
VPS41_YEAST	VPS41	genetic	20093466
SDHX_YEAST	YJL045W	genetic	20093466
YJ24_YEAST	KCH1	genetic	20093466
COX12_YEAST	COX12	genetic	20093466
VRP1_YEAST	VRP1	genetic	20093466
YM30_YEAST	YMR155W	genetic	20093466
YNJ5_YEAST	YNL095C	genetic	20093466
TPM1_YEAST	TPM1	genetic	20093466
INO4_YEAST	INO4	genetic	20093466
VPH1_YEAST	VPH1	genetic	20093466
COX10_YEAST	COX10	genetic	20093466
RL21B_YEAST	RPL21B	genetic	20093466
TAM41_YEAST	TAM41	genetic	20485265
ADT2_YEAST	PET9	genetic	16408847
UPS1_YEAST	UPS1	genetic	23042293

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of PGPS1_YEAST

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-159, AND MASSSPECTROMETRY.	18407956 [Abstract]