SSK22_YEAST - dbPTM
SSK22_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SSK22_YEAST
UniProt AC P25390
Protein Name Serine/threonine-protein kinase SSK22
Gene Name SSK22
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 1331
Subcellular Localization
Protein Description Kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment. Activates the PBS2 MAP kinase kinase by phosphorylation..
Protein Sequence MMMDILNTQQQKAAEGGRVLAPHTISSKLVKRLSSHSSHKLSRSDLKALGGSETISDGPSQLTFKDRYVFNESLYLKKLKKTALDDYYTRGIKLTNRYEEDDGDDEIIRLSNGDRIDEDLHSGVKFFSTTPYCRKMRSDSDELAWNEIATERFKWQSMLARVLKGDIVKGEKTRIANQVKKPGLNKELSDEIWLELKAWLNGRTMQEMEQSLTYLRDSSDSVFEEIMKFQIPQGKILSLDALEAILQDLMNRYHSVVSYWPNLKKMYKDKPITNTAEFTARIDVMNSWLNFKTNLTLRRQELDDWINRFSPISSSDNCQEDFDGVPQWNCKMKILAEQLMKEKNIESIFQKKIFYPLSPWMFKLKLHFIVYRETLTKMNIKYPYERLRSLLAFPVYLIKEVILTRLSYARKLKNPTMMMIDQMIDDFNAFIRLSVQLKYTLTKYCSNLPFDVDFDPTFENTVIEAIRYLFFLLNLKLIDSSKQNFKAPDLLLKYWDHLKNTGHYINGAETVIPNEFLKLTLRLVHKLQFYLLKQQNFPPTFANASEAEKWLSSIFENLGAMKRKLNRFSNILVKAFQNSAVYQINHNAQLVKKLKDAHYFLVYSGNTFESSGVYMFAAPELLGCDNDTILRILRNKSIGCDLVPKLDIGNNLNVYDITTKETDLNILVSKGEDSKGIPYYRVVANSSSDLDRHAHQSKKKNFSTDPFDQHLDEKNNEVFELEVALSSLGALVVLYPGEPVVWDGPVYKLPGNNLFASNEMDLGKIGNPNTLILLNQGSNYALTYQIDKFNQTVGDSVSFIEKRCSLNSIESSLQKINKAYYKLTYTVLNNYKGILGSFMKQCPGNELLNSIFMFGRDFGRSFLKYNAFSSKRKYVIIFLMVKLGMNWLKFLVEECDPTDQRTFRWCVLAMDFAMQMTSGYNILALNVKQFQELKERVSVCMSLLISHFDVMGARATEAENGMQQARLNIDTEENIDEEATLEINSRLRLEAIKTLEKTMKRNPRQMGKVLDATDQGNKYLLSLASSLSNVSMRWQKRSFIGGGTFGQVYSAINLENGEILAVKEIKIHDTTTMKKIFPLIKEEMTVLEMLNHPNIVQYYGVEVHRDKVNIFMEYCEGGSLASLLDHGRIEDEMVTQVYTFELLEGLAYLHQSGVVHRDIKPENILLDFNGIIKYVDFGTARTVVGSRTRTVRNAAVQDFGVETKSLNEMMGTPMYMAPETISGSAVKGKLGADDVWALGCVVLEMATGRRPWSNLDNEWAIMYHVAAGRIPQLPNRDEMTAAGRAFLERCLVQDPTMRATAVELLIDPWMIQIREIAFGNSEKDQVPILSS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
26PhosphorylationVLAPHTISSKLVKRL
CCCCHHHCHHHHHHH		23.6823749301
52PhosphorylationDLKALGGSETISDGP
HHHHHCCCCCCCCCC		29.7519779198
54PhosphorylationKALGGSETISDGPSQ
HHHCCCCCCCCCCCC		27.7219779198
63PhosphorylationSDGPSQLTFKDRYVF
CCCCCCCEECCCEEE		22.4719779198
138PhosphorylationPYCRKMRSDSDELAW
HHHHHCCCCCCHHHH		37.6628889911
140PhosphorylationCRKMRSDSDELAWNE
HHHCCCCCCHHHHHH		33.9428889911
204PhosphorylationKAWLNGRTMQEMEQS
HHHHCCCCHHHHHHH		25.3028889911
211PhosphorylationTMQEMEQSLTYLRDS
CHHHHHHHHHHHHCC		14.9028889911
214PhosphorylationEMEQSLTYLRDSSDS
HHHHHHHHHHCCCHH		12.6728889911
273PhosphorylationMYKDKPITNTAEFTA
HHCCCCCCCCHHHHE		34.7427017623
275PhosphorylationKDKPITNTAEFTARI
CCCCCCCCHHHHEEH		20.9327017623
374PhosphorylationHFIVYRETLTKMNIK
EEEEHHHHHHHCCCC		30.6327017623
468PhosphorylationTVIEAIRYLFFLLNL
HHHHHHHHHHHHHHH		11.1825533186
637PhosphorylationLRILRNKSIGCDLVP
HHHHHCCCCCCCCCC		27.9728889911
686PhosphorylationYYRVVANSSSDLDRH
EEEEEECCCCHHHHH		22.8328889911
1075UbiquitinationHDTTTMKKIFPLIKE
CCCCHHHHHHHHHHH		38.4617644757
1081UbiquitinationKKIFPLIKEEMTVLE
HHHHHHHHHHHCHHH		56.1317644757
1203PhosphorylationVQDFGVETKSLNEMM
HHHHCCCCCCHHHHC		24.4328889911
1205PhosphorylationDFGVETKSLNEMMGT
HHCCCCCCHHHHCCC		43.7928889911
1215PhosphorylationEMMGTPMYMAPETIS
HHCCCCCEECCCCCC		7.4219779198
1220PhosphorylationPMYMAPETISGSAVK
CCEECCCCCCCCCCC		21.2727017623
1222PhosphorylationYMAPETISGSAVKGK
EECCCCCCCCCCCCC		33.8330377154
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SSK22_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SSK22_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SSK22_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
PBS2_YEASTPBS2physical
12853477
HLR1_YEASTHLR1genetic
11532139
LRE1_YEASTLRE1genetic
11532139
ROD1_YEASTROD1physical
16319894
OPI1_YEASTOPI1physical
16319894
SYSC_YEASTSES1physical
16319894
AGE1_YEASTAGE1physical
16319894
TRPF_YEASTTRP1physical
16319894
BMS1_YEASTBMS1physical
16319894
CDC15_YEASTCDC15physical
16319894
SIP4_YEASTSIP4physical
16319894
PDI_YEASTPDI1physical
16319894
RE104_YEASTREC104physical
16319894
MBP1_YEASTMBP1physical
16319894
ASND1_YEASTYML096Wphysical
16319894
HNT1_YEASTHNT1physical
16319894
PAH1_YEASTPAH1physical
16319894
PRM10_YEASTPRM10physical
16319894
YN11A_YEASTYNL284C-Aphysical
16319894
PCL10_YEASTPCL10physical
16319894
SSK1_YEASTSSK1physical
18719252
CANB_YEASTCNB1genetic
19269370
DOA1_YEASTDOA1genetic
19269370
SSK2_YEASTSSK2genetic
9742096
STE11_YEASTSTE11genetic
9742096
WSC3_YEASTWSC3genetic
11532139
GPD1_YEASTGPD1genetic
12724381
FPS1_YEASTFPS1genetic
12724381
ENP1_YEASTENP1physical
20489023
MMF1_YEASTMMF1physical
20489023
SEC7_YEASTSEC7physical
20489023
SSK1_YEASTSSK1physical
20489023
SSK2_YEASTSSK2physical
20489023
OPY2_YEASTOPY2genetic
20932477
STE20_YEASTSTE20genetic
20932477
STE50_YEASTSTE50genetic
9744864
STE20_YEASTSTE20genetic
9744864
CAJ1_YEASTCAJ1genetic
27708008
RIM15_YEASTRIM15genetic
27708008
PRY1_YEASTPRY1genetic
27708008
GSH1_YEASTGSH1genetic
27708008
PTK2_YEASTPTK2genetic
27708008
VPS24_YEASTVPS24genetic
27708008
DCOR_YEASTSPE1genetic
27708008
RL22A_YEASTRPL22Agenetic
27708008
SWI6_YEASTSWI6genetic
27708008
SST2_YEASTSST2genetic
27708008
MSC1_YEASTMSC1genetic
27708008
LEU1_YEASTLEU4genetic
27708008
BRE5_YEASTBRE5genetic
27708008
MSA1_YEASTMSA1genetic
27708008
SUR1_YEASTSUR1genetic
27708008
RU2A_YEASTLEA1genetic
27708008
RAD17_YEASTRAD17genetic
27453043
MRE11_YEASTMRE11genetic
27453043
SERB_YEASTSER2genetic
27453043
GCY1_YEASTGCY1genetic
27453043
TDA5_YEASTTDA5genetic
27453043
PPA5_YEASTPHO5genetic
27453043
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SSK22_YEAST

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Related Literatures of Post-Translational Modification

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