| UniProt ID | PCL10_YEAST | |
|---|---|---|
| UniProt AC | P53124 | |
| Protein Name | PHO85 cyclin-10 | |
| Gene Name | PCL10 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 433 | |
| Subcellular Localization | Cytoplasm . | |
| Protein Description | Cyclin partner of the cyclin-dependent kinase (CDK) PHO85. Together with cyclin PCL8, negatively controls glycogen accumulation under favorable growth conditions. The PCL10-PHO85 cyclin-CDK holoenzyme has glycogen synthase kinase activity and phosphorylates and negatively regulates glycogen synthase GSY2. Also has minor GLC8 kinase activity.. | |
| Protein Sequence | MDMTKNHTTDTEEFDDGDIRPVSLGIVDDYNASFELPLKPKFLQSENFSDLTSEWDQSRSNTPGLAEGKTEKAQPCGTTDSSKNRIHVEQLLESANEMNNYLAQNIENINNFQVGLLNGGKGLYSSMGDDSSACINGTNFSSTSNFELSDDELEDTTGCTSSIFDKDLFHQQNGLSIPRRRSPLFKSPTASFEIGDATDVEEQDIDDSIFSECSSITSFDMGGLHISLPHDEEEDQEKTKSESENPLLHGIPVDVEVPHISVDEALANFKETIELLLKLSGNRKCTGFNTRVEKKEYSNFYMKSKPTLSSADFLKRIQDKCEYQPTVYLVATFLIDTLFLTRDGNNILQLKLNLQEKEVHRMIIAAVRLSTKLLEDFVHSHEYFSKVCGISKRLLTKLEVSLLICVCNTKLMVSNRKLAASKLLLNELRSFCV | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 45 | Phosphorylation | LKPKFLQSENFSDLT CCCHHHCCCCHHHCC | 36.33 | 28889911 | |
| 49 | Phosphorylation | FLQSENFSDLTSEWD HHCCCCHHHCCHHHH | 43.20 | 28889911 | |
| 53 | Phosphorylation | ENFSDLTSEWDQSRS CCHHHCCHHHHHHHC | 43.94 | 27017623 | |
| 58 | Phosphorylation | LTSEWDQSRSNTPGL CCHHHHHHHCCCCCC | 34.89 | 21440633 | |
| 60 | Phosphorylation | SEWDQSRSNTPGLAE HHHHHHHCCCCCCCC | 50.75 | 22369663 | |
| 62 | Phosphorylation | WDQSRSNTPGLAEGK HHHHHCCCCCCCCCC | 21.71 | 22369663 | |
| 176 | Phosphorylation | FHQQNGLSIPRRRSP HHHCCCCCCCCCCCC | 31.76 | 24961812 | |
| 182 | Phosphorylation | LSIPRRRSPLFKSPT CCCCCCCCCCCCCCC | 24.92 | 20377248 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of PCL10_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of PCL10_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of PCL10_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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