RGC1_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RGC1_YEAST
• UniProt AC: Q06108
• Protein Name: Regulator of the glycerol channel 1
• Gene Name: RGC1
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 1083
• Subcellular Localization: Cytoplasm .
• Protein Description: Positive regulator of FPS1 glycerol channel required for the glycerol efflux..
• Protein Sequence: MSDYFTFPKQENGGISKQPATPGSTRSSSRNLELPKNYRSFGGSSDELASMYSADSQYLMDMIPDSLTLKNEPASGNTQMNGPDGKENKDIKLDEYILPKTDPRSPYYINMPIPKKLPKSEGKARAKQKVNRADPSDLDVENIYETSGEFVREYPTDILIDRFHKWKKILKSLIAYFREAAYSQEQIARINYQMKNAVKFAFLTDLEDETNKLVDPSISKLPTKKPQPVPLAAQKLDSKYDTDVEQPQSIQSVPSEEVASASSGFMKFGSGSIQDIQVILKKYHLSLGSQQYKISKEILAYIIPKLTDLRKDLTTKMKEIKELNGDFKTNIGEHIKITSRLLNKYIASVKLLDEASTSGDKQGEKLKPKHDPYLLKLQLDLQLKRQLLEENYLREAFLNLQSAALQLEKIVYSKIQSALQRYSALIDSEARLMIKNLCHELQQGILSRPPAVEWDNFVSHHPTCLMNLKSTDPPPQPRRLSDIVYPNMKSPLAKCIRVGYLLKKTESSKSFTKGYFVLTTNYLHEFKSSDFFLDSKSPRSKNKPVVEQSDISRVNKDGTNAGSHPSSKGTQDPKLTKRRKGLSSSNLYPISSLSLNDCSLKDSTDSTFVLQGYASYHSPEDTCTKESSTTSDLACPTKTLASNKGKHQRTPSALSMVSVPKFLKSSSVPKEQKKAKEEANINKKSICEKRVEWTFKIFSASLEPTPEESKNFKKWVQDIKALTSFNSTQERSNFIEEKILKSRNHNNGKSSQRSKNSTYITPVDSFVNLSEKVTPSSSVTTLNTRKRANRPRYIDIPKSANMNAGAMNSVYRSKVNTPAIDENGNLAIVGETKNSAPQNGMSYTIRTPCKSPYSPYTGEGMLYNRSADNLMASSSRKASAPGEVPQIAVSNHGDEAIIPASAYSDSSHKSSRASSVASIHNQRVDFYPSPLMNLPGVSPSCLALDGNANGYFGIPLNCNSEARRGSDLSPFEMESPLFEENRTQNCSGSRKSSACHIPHQCGPRKEGNDSRLIYGNEKGASQSRLTLKEPLTSKGVEAPYSSLKKTYSAENVPLTSTVSNDKSLHSRKEGSTNTVPATSASSK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
21	Phosphorylation	GISKQPATPGSTRSS CCCCCCCCCCCCCCC	34.56	21440633
24	Phosphorylation	KQPATPGSTRSSSRN CCCCCCCCCCCCCCC	23.11	21440633
25	Phosphorylation	QPATPGSTRSSSRNL CCCCCCCCCCCCCCC	40.25	21440633
27	Phosphorylation	ATPGSTRSSSRNLEL CCCCCCCCCCCCCCC	32.52	19823750
28	Phosphorylation	TPGSTRSSSRNLELP CCCCCCCCCCCCCCC	29.99	21440633
29	Phosphorylation	PGSTRSSSRNLELPK CCCCCCCCCCCCCCC	26.83	19779198
107	Phosphorylation	KTDPRSPYYINMPIP CCCCCCCCEECCCCC	20.44	21440633
136	Phosphorylation	KVNRADPSDLDVENI HHHCCCHHHCCHHHH	51.89	28889911
204	Phosphorylation	AVKFAFLTDLEDETN HHHHEEECCCCHHHC	31.89	28889911
217	Phosphorylation	TNKLVDPSISKLPTK HCCCCCCHHHCCCCC	34.72	27214570
249	Phosphorylation	TDVEQPQSIQSVPSE CCCCCCCCCCCCCHH	29.31	21440633
252	Phosphorylation	EQPQSIQSVPSEEVA CCCCCCCCCCHHHHH	34.03	21440633
255	Phosphorylation	QSIQSVPSEEVASAS CCCCCCCHHHHHHCC	44.21	19779198
260	Phosphorylation	VPSEEVASASSGFMK CCHHHHHHCCCCCEE	33.58	19779198
270	Phosphorylation	SGFMKFGSGSIQDIQ CCCEECCCCCHHHHH	32.28	28889911
272	Phosphorylation	FMKFGSGSIQDIQVI CEECCCCCHHHHHHH	20.83	30377154
286	Phosphorylation	ILKKYHLSLGSQQYK HHHHHHHHCCCCCHH	19.85	25882841
289	Phosphorylation	KYHLSLGSQQYKISK HHHHHCCCCCHHCCH	21.28	25882841
329	Phosphorylation	ELNGDFKTNIGEHIK HHCCCCCCCHHHHHH	31.87	21440633
344	Acetylation	ITSRLLNKYIASVKL HHHHHHHHHHHHHEE	37.69	24489116
356	Phosphorylation	VKLLDEASTSGDKQG HEEHHHHCCCCCCCC	22.51	28889911
357	Phosphorylation	KLLDEASTSGDKQGE EEHHHHCCCCCCCCC	43.72	28889911
358	Phosphorylation	LLDEASTSGDKQGEK EHHHHCCCCCCCCCC	42.36	28889911
423	Phosphorylation	QSALQRYSALIDSEA HHHHHHHHHHHCHHH	20.84	28889911
447	Phosphorylation	ELQQGILSRPPAVEW HHHHCHHCCCCCCCC	40.60	28889911
481	Phosphorylation	PPQPRRLSDIVYPNM CCCCCCHHHCCCCCC	24.39	22369663
485	Phosphorylation	RRLSDIVYPNMKSPL CCHHHCCCCCCCCHH	6.82	22369663
535	Phosphorylation	SSDFFLDSKSPRSKN CCCCCCCCCCCCCCC	36.86	22369663
537	Phosphorylation	DFFLDSKSPRSKNKP CCCCCCCCCCCCCCC	29.51	22369663
585	Phosphorylation	RRKGLSSSNLYPISS CCCCCCCCCCEECCC	27.72	28889911
630	Phosphorylation	CTKESSTTSDLACPT CCCCCCCCCCCCCCH	23.38	28889911
631	Phosphorylation	TKESSTTSDLACPTK CCCCCCCCCCCCCHH	30.62	28889911
637	Phosphorylation	TSDLACPTKTLASNK CCCCCCCHHHHHCCC	36.22	28889911
650	Phosphorylation	NKGKHQRTPSALSMV CCCCCCCCCCHHHHH	18.28	22890988
652	Phosphorylation	GKHQRTPSALSMVSV CCCCCCCCHHHHHHH	41.03	22369663
655	Phosphorylation	QRTPSALSMVSVPKF CCCCCHHHHHHHHHH	19.49	22890988
656	Oxidation	RTPSALSMVSVPKFL CCCCHHHHHHHHHHH	2.44	15665377
658	Phosphorylation	PSALSMVSVPKFLKS CCHHHHHHHHHHHHC	24.86	24961812
665	Phosphorylation	SVPKFLKSSSVPKEQ HHHHHHHCCCCCHHH	29.96	21126336
738	Acetylation	RSNFIEEKILKSRNH HHHHHHHHHHHCCCC	40.32	24489116
742	Phosphorylation	IEEKILKSRNHNNGK HHHHHHHCCCCCCCC	34.56	21551504
757	Phosphorylation	SSQRSKNSTYITPVD CCCCCCCCCEEEECH	26.73	22369663
758	Phosphorylation	SQRSKNSTYITPVDS CCCCCCCCEEEECHH	28.47	22369663
759	Phosphorylation	QRSKNSTYITPVDSF CCCCCCCEEEECHHH	11.56	22369663
761	Phosphorylation	SKNSTYITPVDSFVN CCCCCEEEECHHHCC	13.57	22369663
765	Phosphorylation	TYITPVDSFVNLSEK CEEEECHHHCCCCCC	31.18	22369663
770	Phosphorylation	VDSFVNLSEKVTPSS CHHHCCCCCCCCCCC	30.12	22369663
774	Phosphorylation	VNLSEKVTPSSSVTT CCCCCCCCCCCCCCC	28.64	22369663
776	Phosphorylation	LSEKVTPSSSVTTLN CCCCCCCCCCCCCCC	26.36	20377248
777	Phosphorylation	SEKVTPSSSVTTLNT CCCCCCCCCCCCCCC	29.99	22369663
778	Phosphorylation	EKVTPSSSVTTLNTR CCCCCCCCCCCCCCC	28.02	22369663
780	Phosphorylation	VTPSSSVTTLNTRKR CCCCCCCCCCCCCCC	27.75	23749301
781	Phosphorylation	TPSSSVTTLNTRKRA CCCCCCCCCCCCCCC	18.82	22369663
784	Phosphorylation	SSVTTLNTRKRANRP CCCCCCCCCCCCCCC	40.45	21440633
793	Phosphorylation	KRANRPRYIDIPKSA CCCCCCCCCCCCCCC	12.96	28889911
809	Phosphorylation	MNAGAMNSVYRSKVN CCHHHCCHHHHHCCC	13.87	22369663
811	Phosphorylation	AGAMNSVYRSKVNTP HHHCCHHHHHCCCCC	14.69	22369663
813	Phosphorylation	AMNSVYRSKVNTPAI HCCHHHHHCCCCCCC	24.22	22369663
817	Phosphorylation	VYRSKVNTPAIDENG HHHHCCCCCCCCCCC	19.65	22369663
832	Phosphorylation	NLAIVGETKNSAPQN CEEEEEECCCCCCCC	29.60	21440633
835	Phosphorylation	IVGETKNSAPQNGMS EEEECCCCCCCCCCC	42.77	28889911
847	Phosphorylation	GMSYTIRTPCKSPYS CCCEEEECCCCCCCC	29.23	21440633
851	Phosphorylation	TIRTPCKSPYSPYTG EEECCCCCCCCCCCC	35.47	23749301
853	Phosphorylation	RTPCKSPYSPYTGEG ECCCCCCCCCCCCCC	29.39	28889911
854	Phosphorylation	TPCKSPYSPYTGEGM CCCCCCCCCCCCCCC	18.14	25752575
856	Phosphorylation	CKSPYSPYTGEGMLY CCCCCCCCCCCCCCE	22.80	21440633
857	Phosphorylation	KSPYSPYTGEGMLYN CCCCCCCCCCCCCEE	31.94	23749301
863	Phosphorylation	YTGEGMLYNRSADNL CCCCCCCEECCHHHH	10.31	20377248
866	Phosphorylation	EGMLYNRSADNLMAS CCCCEECCHHHHHCC	36.01	22369663
873	Phosphorylation	SADNLMASSSRKASA CHHHHHCCCCCCCCC	18.19	22890988
874	Phosphorylation	ADNLMASSSRKASAP HHHHHCCCCCCCCCC	25.32	22890988
875	Phosphorylation	DNLMASSSRKASAPG HHHHCCCCCCCCCCC	34.99	22890988
879	Phosphorylation	ASSSRKASAPGEVPQ CCCCCCCCCCCCCCE	37.72	28889911
890	Phosphorylation	EVPQIAVSNHGDEAI CCCEEEEECCCCCCE	17.68	19823750
901	Phosphorylation	DEAIIPASAYSDSSH CCCEEEHHHCCCCCC	23.53	20377248
903	Phosphorylation	AIIPASAYSDSSHKS CEEEHHHCCCCCCCC	15.54	20377248
904	Phosphorylation	IIPASAYSDSSHKSS EEEHHHCCCCCCCCC	30.63	20377248
906	Phosphorylation	PASAYSDSSHKSSRA EHHHCCCCCCCCCCH	28.53	20377248
907	Phosphorylation	ASAYSDSSHKSSRAS HHHCCCCCCCCCCHH	39.67	20377248
910	Phosphorylation	YSDSSHKSSRASSVA CCCCCCCCCCHHHHH	21.45	19779198
914	Phosphorylation	SHKSSRASSVASIHN CCCCCCHHHHHHHCC	25.00	22369663
915	Phosphorylation	HKSSRASSVASIHNQ CCCCCHHHHHHHCCC	22.25	22369663
918	Phosphorylation	SRASSVASIHNQRVD CCHHHHHHHCCCCCC	23.40	22369663
966	Phosphorylation	NSEARRGSDLSPFEM CCCHHCCCCCCCCCC	33.30	22369663
969	Phosphorylation	ARRGSDLSPFEMESP HHCCCCCCCCCCCCC	32.31	22369663
975	Phosphorylation	LSPFEMESPLFEENR CCCCCCCCCCCCCCC	26.12	22369663
987	Phosphorylation	ENRTQNCSGSRKSSA CCCCCCCCCCCCCCC	47.56	27017623
989	Phosphorylation	RTQNCSGSRKSSACH CCCCCCCCCCCCCCC	21.90	19779198
992	Phosphorylation	NCSGSRKSSACHIPH CCCCCCCCCCCCCCC	23.27	19779198
993	Phosphorylation	CSGSRKSSACHIPHQ CCCCCCCCCCCCCCC	37.64	29136822
1010	Phosphorylation	PRKEGNDSRLIYGNE CCCCCCCCEEEECCC	32.74	21440633
1021	Phosphorylation	YGNEKGASQSRLTLK ECCCCCCCCCCEEEC	37.04	22369663
1023	Phosphorylation	NEKGASQSRLTLKEP CCCCCCCCCEEECCC	27.11	22369663
1026	Phosphorylation	GASQSRLTLKEPLTS CCCCCCEEECCCCCC	34.37	22369663
1032	Phosphorylation	LTLKEPLTSKGVEAP EEECCCCCCCCCCCC	38.82	22369663
1033	Phosphorylation	TLKEPLTSKGVEAPY EECCCCCCCCCCCCH	34.79	22369663
1046	Phosphorylation	PYSSLKKTYSAENVP CHHHHCCCCCCCCCC	22.56	22369663
1047	Phosphorylation	YSSLKKTYSAENVPL HHHHCCCCCCCCCCC	18.11	22369663
1048	Phosphorylation	SSLKKTYSAENVPLT HHHCCCCCCCCCCCC	34.05	22369663
1055	Phosphorylation	SAENVPLTSTVSNDK CCCCCCCCEEECCCC	19.11	22890988
1056	Phosphorylation	AENVPLTSTVSNDKS CCCCCCCEEECCCCC	34.20	22890988
1057	Phosphorylation	ENVPLTSTVSNDKSL CCCCCCEEECCCCCC	23.79	22890988
1059	Phosphorylation	VPLTSTVSNDKSLHS CCCCEEECCCCCCCC	39.12	22369663
1063	Phosphorylation	STVSNDKSLHSRKEG EEECCCCCCCCCCCC	33.89	21440633
1071	Phosphorylation	LHSRKEGSTNTVPAT CCCCCCCCCCCCCCC	21.41	22369663
1072	Phosphorylation	HSRKEGSTNTVPATS CCCCCCCCCCCCCCC	45.85	22369663
1074	Phosphorylation	RKEGSTNTVPATSAS CCCCCCCCCCCCCCC	28.14	23749301
1078	Phosphorylation	STNTVPATSASSK-- CCCCCCCCCCCCC--	20.82	22369663
1079	Phosphorylation	TNTVPATSASSK--- CCCCCCCCCCCC---	28.41	22369663
1081	Phosphorylation	TVPATSASSK----- CCCCCCCCCC-----	38.13	22369663
1082	Phosphorylation	VPATSASSK------ CCCCCCCCC------	41.94	22369663

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RGC1_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RGC1_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RGC1_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ASK10_YEAST	ASK10	genetic	19956799
ERB1_YEAST	ERB1	physical	20489023
FKBP3_YEAST	FPR3	physical	20489023
NOG1_YEAST	NOG1	physical	20489023
PESC_YEAST	NOP7	physical	20489023
PWP1_YEAST	PWP1	physical	20489023
RLP7_YEAST	RLP7	physical	20489023
RRS1_YEAST	RRS1	physical	20489023
ASK10_YEAST	ASK10	genetic	20959818
UBP3_YEAST	UBP3	genetic	20959818
FPS1_YEAST	FPS1	genetic	22030956
ASK10_YEAST	ASK10	genetic	24298058
RGC1_YEAST	RGC1	physical	26024902
ASK10_YEAST	ASK10	physical	26024902
FPS1_YEAST	FPS1	genetic	27607883
VAM3_YEAST	VAM3	genetic	27708008
ATG8_YEAST	ATG8	genetic	27708008
TIP1_YEAST	TIP1	genetic	27708008
YCZ2_YEAST	YCR102C	genetic	27708008
SLX5_YEAST	SLX5	genetic	27708008
SNQ2_YEAST	SNQ2	genetic	27708008
DHAS_YEAST	HOM2	genetic	27708008
ATG1_YEAST	ATG1	genetic	27708008
YG37_YEAST	YGR127W	genetic	27708008
TNA1_YEAST	TNA1	genetic	27708008
IME2_YEAST	IME2	genetic	27708008
PIR5_YEAST	YJL160C	genetic	27708008
ELM1_YEAST	ELM1	genetic	27708008
GBLP_YEAST	ASC1	genetic	27708008
OCA2_YEAST	OCA2	genetic	27708008
VAM10_YEAST	VAM10	genetic	27708008

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-481; SER-535; SER-537;SER-652; SER-778; THR-817; SER-854; SER-866; SER-875; SER-915;SER-918; SER-966; SER-975; THR-1046; TYR-1047; SER-1048 AND SER-1059,AND MASS SPECTROMETRY.
PubMed: 18407956

"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-481 AND THR-817, ANDMASS SPECTROMETRY.
PubMed: 17563356

"Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae.";
Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.;
J. Proteome Res. 6:1190-1197(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-481, AND MASSSPECTROMETRY.
PubMed: 17330950

"Quantitative phosphoproteomics applied to the yeast pheromonesignaling pathway.";
Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J.,Mann M., Jensen O.N.;
Mol. Cell. Proteomics 4:310-327(2005).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-652 AND SER-1048, ANDMASS SPECTROMETRY.
PubMed: 15665377