WSC4_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: WSC4_YEAST
• UniProt AC: P38739
• Protein Name: Cell wall integrity and stress response component 4
• Gene Name: WSC4
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 605
• Subcellular Localization: Membrane ; Single-pass membrane protein .
• Protein Sequence: MQTSMVSAKVSIWLVCSVICSSLVRATQSVCSSQNTATTDGVRNQFQSNGWCSNNCAGHQFAIVQGFMCWCSDSEPSTQTSVGDCSGTCPGYGYEDCGNADKDLFGYIYLGQTPLSSVQSVETSTESSVYVSSSSITSSSSTSIVDTTTISPTLTSTSTTPLTTASTSTTPSTDITSALPTTTSTKLSTSIPTSTTSSTSTTTSTSSSTSTTVSVTSSTSTTTSTTSSTLISTSTSSSSSSTPTTTSSAPISTSTTSSTSTSTSTTSPTSSSAPTSSSNTTPTSTTFTTTSPSTAPSSTTVTYTSTTASPITSTITSVNLQTSLKYSVITVTSVHTMDTNISEITSRYLTMKKVITQIYSSTLGATPTSAVATTSASVGGRITNNNNSNTTNSNTPTNKSTEKKGYWDSPGKIAATFVVVGVVCLVIICILIYLIHHYRTRPARKAQDFENEYQSKFYQSKYPNEVTTTTLHTPSPSSNSTFSTPRLIYTDEKGQIMSESPSPRQSTYSLTAGSPPNDPSTLASPFHDPILPRRTSTFLHSPIQKQHEKMESNVTLGEDTVLVDQRLDPSKMLNTLANDDATNHSTISLSDNVDYSRRVLRLMNE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Phosphorylation	-MQTSMVSAKVSIWL -CCCCHHHHHHHHHH	17.46	28889911
332	Phosphorylation	KYSVITVTSVHTMDT CEEEEEEEEEEECCC	19.17	19779198
340	N-linked_Glycosylation	SVHTMDTNISEITSR EEEECCCCHHHHHHH	31.37	-
346	Phosphorylation	TNISEITSRYLTMKK CCHHHHHHHHHHHHH	25.29	19779198
350	Phosphorylation	EITSRYLTMKKVITQ HHHHHHHHHHHHHHH	20.29	19779198
386	N-linked_Glycosylation	GGRITNNNNSNTTNS CCEEECCCCCCCCCC	56.21	-
389	N-linked_Glycosylation	ITNNNNSNTTNSNTP EECCCCCCCCCCCCC	53.71	-
398	N-linked_Glycosylation	TNSNTPTNKSTEKKG CCCCCCCCCCCCCCC	37.17	-
456	Ubiquitination	FENEYQSKFYQSKYP HCHHHHHHHHHCCCC	32.34	23749301
479	N-linked_Glycosylation	HTPSPSSNSTFSTPR CCCCCCCCCCCCCCE	49.78	-
490	Phosphorylation	STPRLIYTDEKGQIM CCCEEEEECCCCCEE	30.59	27017623
493	Ubiquitination	RLIYTDEKGQIMSES EEEEECCCCCEECCC	59.95	23749301
498	Phosphorylation	DEKGQIMSESPSPRQ CCCCCEECCCCCCCC	36.23	22369663
500	Phosphorylation	KGQIMSESPSPRQST CCCEECCCCCCCCCC	24.30	23749301
502	Phosphorylation	QIMSESPSPRQSTYS CEECCCCCCCCCCCE	41.83	22369663
535	Phosphorylation	DPILPRRTSTFLHSP CCCCCCCCCCCCCCC	33.14	28889911
536	Phosphorylation	PILPRRTSTFLHSPI CCCCCCCCCCCCCCH	18.49	28889911
541	Phosphorylation	RTSTFLHSPIQKQHE CCCCCCCCCHHHHHH	26.33	25704821
553	N-linked_Glycosylation	QHEKMESNVTLGEDT HHHHHHHCCEECCCE	19.93	-
582	Phosphorylation	TLANDDATNHSTISL HHHCCCCCCCCCCCC	40.22	19779198
583	N-linked_Glycosylation	LANDDATNHSTISLS HHCCCCCCCCCCCCC	28.91	-
585	Phosphorylation	NDDATNHSTISLSDN CCCCCCCCCCCCCCC	29.52	27017623
586	Phosphorylation	DDATNHSTISLSDNV CCCCCCCCCCCCCCC	13.66	19779198
588	Phosphorylation	ATNHSTISLSDNVDY CCCCCCCCCCCCCCH	23.16	19779198

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of WSC4_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of WSC4_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of WSC4_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GEM1_YEAST	GEM1	genetic	20093466
SKT5_YEAST	SKT5	genetic	20093466
HMO1_YEAST	HMO1	genetic	20093466
ASK10_YEAST	ASK10	genetic	20093466
RAS2_YEAST	RAS2	genetic	11589572

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.