MPC70_YEAST - dbPTM
MPC70_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID MPC70_YEAST
UniProt AC Q12411
Protein Name Sporulation-specific protein 21
Gene Name SPO21
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 609
Subcellular Localization Prospore membrane. Cytoplasm, cytoskeleton, spindle pole. Localizes to the ends of spindle microtubules in cells in meiosis.
Protein Description Involved in the pathway that organizes the shaping and sizing of the prospore membrane (PSM) during sporulation. May provide a meiosis-specific scaffold for the assembly of other proteins on spindle pole bodies (SPBs), and may be a limiting component for SPB formation..
Protein Sequence MDNILKASNMEGTSTMTVTSRSSEDSSCISNHEQDTDTHKDGDTSGLENSKISKRKWMKEFFKLSKSPASKSSRSIGSMKSNQSLVSMKSSDDGNSYKNDYSSICGNSLPSAGLSRSNSVKELKLDSTGSQRSKNNVAMLARSSTTSQTTCSSSSSSSSYNSIKGNENDILLQNNNHFRHNKEIPQSKGSSNINTASIMSQYNVDTQATAIMSDMQKQYDSQQMTSPFVNEDLHFDPNGEVSHVIKAIFKEIGYKYDDFSDIPVFQLMQEMYQLVKKNSSARRTKITDYASKLKEKEAQLKSQNDKILKLETTNKAYKTKYKEVSLENKKIKEAFKELDNESYNHDEELLKKYKYTRETLDRVNREQQLIIDQNEFLKKSVNELQNEVNATNFKFSLFKEKYAKLADSITELNTSTKKREALGENLTFECNELKEICLKYKKNIENISNTNKNLQNSFKNERKKVLDLRNERNLLKKEILLIECHGSYSLLLVSNILTCYRFLLPSDTIIETESLIKELLNMNNSLSNHVSSSDEPPAEYSKRLELKCVEFEEKLLYFYQELVTKKIIDVIYKCFINYYKKSRQTDQKSNQNSSTPYKQSQRQVPHSIK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
17PhosphorylationMEGTSTMTVTSRSSE
CCCCCEEEEEECCCC		22.2628889911
19PhosphorylationGTSTMTVTSRSSEDS
CCCEEEEEECCCCCC		14.8428889911
20PhosphorylationTSTMTVTSRSSEDSS
CCEEEEEECCCCCCC		26.3128889911
73PhosphorylationKSPASKSSRSIGSMK
CCCCCCCCCCCCCCC		33.5127017623
75PhosphorylationPASKSSRSIGSMKSN
CCCCCCCCCCCCCCC		33.0027017623
81PhosphorylationRSIGSMKSNQSLVSM
CCCCCCCCCCCCEEC		31.3128889911
84PhosphorylationGSMKSNQSLVSMKSS
CCCCCCCCCEECCCC		34.6828889911
96PhosphorylationKSSDDGNSYKNDYSS
CCCCCCCCCCCCHHH		42.9128889911
97PhosphorylationSSDDGNSYKNDYSSI
CCCCCCCCCCCHHHH		20.1528889911
121AcetylationLSRSNSVKELKLDST
CCCCCCCEEEECCCC		58.0925381059
127PhosphorylationVKELKLDSTGSQRSK
CEEEECCCCCCHHHH		45.1427214570
195PhosphorylationKGSSNINTASIMSQY
CCCCCCCHHHHHHHC		20.2727017623
197PhosphorylationSSNINTASIMSQYNV
CCCCCHHHHHHHCCC		19.4527017623
408PhosphorylationKYAKLADSITELNTS
HHHHHHHHHHHCCCC		26.2927017623
410PhosphorylationAKLADSITELNTSTK
HHHHHHHHHCCCCHH		38.0727214570
414PhosphorylationDSITELNTSTKKREA
HHHHHCCCCHHHHHH		50.8527017623
448PhosphorylationKKNIENISNTNKNLQ
HHHHHHHCCCCHHHH		49.5421126336
450PhosphorylationNIENISNTNKNLQNS
HHHHHCCCCHHHHHH		40.5628889911
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of MPC70_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of MPC70_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of MPC70_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
ADY4_YEASTADY4physical
12796288
MPC54_YEASTMPC54physical
12796288
SPO74_YEASTSPO74physical
12796288
MPC54_YEASTMPC54physical
10899120
MPC70_YEASTSPO21physical
10899120
NUD1_YEASTNUD1physical
10899120
SPC42_YEASTSPC42physical
10899120
SPO74_YEASTSPO74genetic
15034143
CNM67_YEASTCNM67physical
20826607
MPC70_YEASTSPO21physical
20826607
MPC54_YEASTMPC54physical
20826607
YET3_YEASTYET3physical
22875988
IVY1_YEASTIVY1physical
22875988
NACB2_YEASTBTT1physical
22875988
RT103_YEASTRTT103physical
22875988
SNX41_YEASTSNX41physical
22875988
CCM1_YEASTCCM1physical
22875988
VPS53_YEASTVPS53physical
22875988
SA185_YEASTSAP185physical
22875988
RE107_YEASTREC107physical
22875988
EAF6_YEASTEAF6physical
22875988
NNF1_YEASTNNF1physical
22875988
YKF0_YEASTYKL050Cphysical
22875988
BLI1_YEASTBLI1physical
22875988
NKP2_YEASTNKP2physical
22875988
BUD6_YEASTBUD6physical
22875988
STB2_YEASTSTB2physical
22875988
STV1_YEASTSTV1physical
22875988
PDS5_YEASTPDS5physical
22875988
VPS20_YEASTVPS20physical
22875988
NOP2_YEASTNOP2physical
22875988
END3_YEASTEND3physical
22875988
YO223_YEASTDSC3physical
22875988
YO304_YEASTBIL1physical
22875988
SCD5_YEASTSCD5physical
22875988
LGE1_YEASTLGE1physical
22875988
TBP6_YEASTYTA6physical
22875988
GYP5_YEASTGYP5physical
22875988
NCA2_YEASTNCA2physical
22875988
ASK10_YEASTASK10genetic
27708008
COQ2_YEASTCOQ2genetic
27708008
PP2C4_YEASTPTC4genetic
27708008
HEL2_YEASTHEL2genetic
27708008
SGPL_YEASTDPL1genetic
27708008
HUR1_YEASTHUR1genetic
27708008
YG5B_YEASTYGR250Cgenetic
27708008
TBP7_YEASTYTA7genetic
27708008
PIH1_YEASTPIH1genetic
27708008
HTD2_YEASTHTD2genetic
27708008
POG1_YEASTPOG1genetic
27708008
MPM1_YEASTMPM1genetic
27708008
PHO90_YEASTPHO90genetic
27708008
ECM25_YEASTECM25genetic
27708008
RT109_YEASTRTT109genetic
27708008
ERG3_YEASTERG3genetic
27708008
ADY4_YEASTADY4genetic
27708008
MSO1_YEASTMSO1genetic
27708008
MTHR1_YEASTMET12genetic
27708008
RMI1_YEASTRMI1genetic
27708008
CG12_YEASTCLN2genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of MPC70_YEAST

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Related Literatures of Post-Translational Modification

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