GUP2_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GUP2_YEAST
• UniProt AC: Q08929
• Protein Name: Glycerol uptake protein 2
• Gene Name: GUP2
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 609
• Subcellular Localization: Membrane ; Multi-pass membrane protein .
• Protein Description: Involved in active uptake of glycerol driven by electrogenic proton symport..
• Protein Sequence: MSMLRIWSCIVHFFSVQALDSRIKPDIEFKRRQRIFINSSKEENGSSSSAVTVTRNPVLSSNSPSPPLWNTWEFRLYYLAFTVVVPFMIKAALATSSESNPNYYKFSGLLAHGWILGRKVDNSDPQYRFFRSNFFLLAILILLQIILKKVFVKFSKIPKTKFDFACGLVFVCFMYGINSVKLFTHAFIFFTLAHSLKRKRLIAAFAIWSYGIFTLFINQKMKNLPFNNIAIILSPMDQWYKGIVPRWDFFFNFTLLRLLSYSMDFLERWHEQLSRQPSIDYDDRRPEFRKSLSGSTLQTIYESGKNVLEEKERLVAEHHIQDYNFINFIAYITYAPLFLVGPIITFNDYLYQSENKLPSLTKKNIGFYALKVFSSLLLMEIILHYIYVGAIARTKAWNNDTPLQQAMIALFNLNIMYLKLLIPWRLFRLWAMVDGIDAPENMLRCVDNNYSTVGFWRAWHTSFNKWVIRYIYVPFGGSNNKILTSFAVFSFVAIWHDIQLRVLFWGWLTVLLLLGETYITNCFSRYRFRSWYRFVCGIGAAINICMMMIINVYGFCLGAEGTKLLLKGIFNNSHSPEFLTAVMVSLFIAVQVMFEIREEEKRHGINLKC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
21	Phosphorylation	FSVQALDSRIKPDIE HHHHHHHCCCCCCCC	36.43	27017623
293	Phosphorylation	PEFRKSLSGSTLQTI HHHHHHCCCCHHHHH	37.48	21440633
295	Phosphorylation	FRKSLSGSTLQTIYE HHHHCCCCHHHHHHH	23.67	24961812
299	Phosphorylation	LSGSTLQTIYESGKN CCCCHHHHHHHHCCC	28.74	28889911
301	Phosphorylation	GSTLQTIYESGKNVL CCHHHHHHHHCCCHH	13.87	27017623
303	Phosphorylation	TLQTIYESGKNVLEE HHHHHHHHCCCHHHH	37.79	27017623

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GUP2_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GUP2_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GUP2_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GLPK_YEAST	GUT1	genetic	15135071
PHO88_YEAST	PHO88	physical	16093310
MKAR_YEAST	IFA38	physical	16093310
STE2_YEAST	STE2	physical	16093310
PDX3_YEAST	PDX3	genetic	21623372
PDC6_YEAST	PDC6	genetic	21623372
THDH_YEAST	ILV1	genetic	21623372
6PGD1_YEAST	GND1	genetic	21623372
KCS1_YEAST	KCS1	genetic	21623372
SYSM_YEAST	DIA4	genetic	21623372
COX6_YEAST	COX6	genetic	21623372
PHO84_YEAST	PHO84	genetic	21623372
FOLE_YEAST	MET7	genetic	21623372
ADK_YEAST	ADO1	genetic	21623372
COX5A_YEAST	COX5A	genetic	21623372
ADE_YEAST	AAH1	genetic	21623372
QCR1_YEAST	COR1	genetic	21623372
COQ7_YEAST	CAT5	genetic	21623372
SLX8_YEAST	SLX8	genetic	27708008
VMA21_YEAST	VMA21	genetic	27708008
OSW2_YEAST	OSW2	genetic	27708008
AVO2_YEAST	AVO2	genetic	27708008
NAA38_YEAST	MAK31	genetic	27708008
MTU1_YEAST	SLM3	genetic	27708008
GPR1_YEAST	GPR1	genetic	27708008
VAM6_YEAST	VAM6	genetic	27708008
ATC4_YEAST	DNF2	genetic	27708008
AIM11_YEAST	AIM11	genetic	27708008
RAD4_YEAST	RAD4	genetic	27708008
TYW3_YEAST	TYW3	genetic	27708008
YGI2_YEAST	YGL082W	genetic	27708008
GTS1_YEAST	GTS1	genetic	27708008
SOL4_YEAST	SOL4	genetic	27708008
MED20_YEAST	SRB2	genetic	27708008
PPME1_YEAST	PPE1	genetic	27708008
PRM2_YEAST	PRM2	genetic	27708008
REV7_YEAST	REV7	genetic	27708008
VPS53_YEAST	VPS53	genetic	27708008
CSN12_YEAST	YJR084W	genetic	27708008
IME1_YEAST	IME1	genetic	27708008
ENT3_YEAST	ENT3	genetic	27708008
PTM1_YEAST	PTM1	genetic	27708008
LOT5_YEAST	LOT5	genetic	27708008
PRY2_YEAST	PRY2	genetic	27708008
FMP46_YEAST	FMP46	genetic	27708008
DIA1_YEAST	DIA1	genetic	27708008
IPB2_YEAST	PBI2	genetic	27708008

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.