ATC4_YEAST - dbPTM
ATC4_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ATC4_YEAST
UniProt AC Q12675
Protein Name Phospholipid-transporting ATPase DNF2
Gene Name DNF2
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 1612
Subcellular Localization Cell membrane
Multi-pass membrane protein .
Protein Description This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids. Required for protein transport from Golgi to vacuoles..
Protein Sequence MSSPSKPTSPFVDDIEHESGSASNGLSSMSPFDDSFQFEKPSSAHGNIEVAKTGGSVLKRQSKPMKDISTPDLSKVTFDGIDDYSNDNDINDDDELNGKKTEIHEHENEVDDDLHSFQATPMPNTGGFEDVELDNNEGSNNDSQADHKLKRVRFGTRRNKSGRIDINRSKTLKWAKKNFHNAIDEFSTKEDSLENSALQNRSDELRTVYYNLPLPEDMLDEDGLPLAVYPRNKIRTTKYTPLTFFPKNILFQFHNFANIYFLILLILGAFQIFGVTNPGFASVPLIVIVIITAIKDGIEDSRRTVLDLEVNNTRTHILSGVKNENVAVDNVSLWRRFKKANTRALIKIFEYFSENLTAAGREKKLQKKREELRRKRNSRSFGPRGSLDSIGSYRMSADFGRPSLDYENLNQTMSQANRYNDGENLVDRTLQPNPECRFAKDYWKNVKVGDIVRVHNNDEIPADMILLSTSDVDGACYVETKNLDGETNLKVRQSLKCSKIIKSSRDITRTKFWVESEGPHANLYSYQGNFKWQDTQNGNIRNEPVNINNLLLRGCTLRNTKWAMGMVIFTGDDTKIMINAGVTPTKKSRISRELNFSVILNFVLLFILCFTAGIVNGVYYKQKPRSRDYFEFGTIGGSASTNGFVSFWVAVILYQSLVPISLYISVEIIKTAQAIFIYTDVLLYNAKLDYPCTPKSWNISDDLGQIEYIFSDKTGTLTQNVMEFKKCTINGVSYGRAYTEALAGLRKRQGVDVESEGRREKEEIAKDRETMIDELRSMSDNTQFCPEDLTFVSKEIVEDLKGSSGDHQQKCCEHFLLALALCHSVLVEPNKDDPKKLDIKAQSPDESALVSTARQLGYSFVGSSKSGLIVEIQGVQKEFQVLNVLEFNSSRKRMSCIIKIPGSTPKDEPKALLICKGADSVIYSRLDRTQNDATLLEKTALHLEEYATEGLRTLCLAQRELTWSEYERWVKTYDVAAASVTNREEELDKVTDVIERELILLGGTAIEDRLQDGVPDSIALLAEAGIKLWVLTGDKVETAINIGFSCNVLNNDMELLVVKASGEDVEEFGSDPIQVVNNLVTKYLREKFGMSGSEEELKEAKREHGLPQGNFAVIIDGDALKVALNGEEMRRKFLLLCKNCKAVLCCRVSPAQKAAVVKLVKKTLDVMTLAIGDGSNDVAMIQSADVGVGIAGEEGRQAVMCSDYAIGQFRYVTRLVLVHGKWCYKRLAEMIPQFFYKNVIFTLSLFWYGIYNNFDGSYLFEYTYLTFYNLAFTSVPVILLAVLDQDVSDTVSMLVPQLYRVGILRKEWNQTKFLWYMLDGVYQSVICFFFPYLAYHKNMVVTENGLGLDHRYFVGVFVTAIAVTSCNFYVFMEQYRWDWFCGLFICLSLAVFYGWTGIWTSSSSSNEFYKGAARVFAQPAYWAVLFVGVLFCLLPRFTIDCIRKIFYPKDIEIVREMWLRGDFDLYPQGYDPTDPSRPRINEIRPLTDFKEPISLDTHFDGVSHSQETIVTEEIPMSILNGEQGSRKGYRVSTTLERRDQLSPVTTTNNLPRRSMASARGNKLRTSLDRTREEMLANHQLDTRYSVERARASLDLPGINHAETLLSQRSRDR
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
42PhosphorylationSFQFEKPSSAHGNIE
CCCCCCCCCCCCCEE		51.7529734811
43PhosphorylationFQFEKPSSAHGNIEV
CCCCCCCCCCCCEEE		32.5828889911
56PhosphorylationEVAKTGGSVLKRQSK
EEEECCCCHHHCCCC		26.1423749301
62PhosphorylationGSVLKRQSKPMKDIS
CCHHHCCCCCCCCCC		42.6421551504
69PhosphorylationSKPMKDISTPDLSKV
CCCCCCCCCCCHHHC		43.9822369663
70PhosphorylationKPMKDISTPDLSKVT
CCCCCCCCCCHHHCE		22.5822369663
74PhosphorylationDISTPDLSKVTFDGI
CCCCCCHHHCEECCC		32.2421551504
77PhosphorylationTPDLSKVTFDGIDDY
CCCHHHCEECCCCCC		21.5322369663
84PhosphorylationTFDGIDDYSNDNDIN
EECCCCCCCCCCCCC		12.9622369663
85PhosphorylationFDGIDDYSNDNDIND
ECCCCCCCCCCCCCC		44.7122369663
99UbiquitinationDDDELNGKKTEIHEH
CCHHHCCCCCEEEEC		56.2923749301
161PhosphorylationFGTRRNKSGRIDINR
HCCCCCCCCCEECCH		36.5327717283
386PhosphorylationRSFGPRGSLDSIGSY
CCCCCCCCCCCCCCE		30.2223749301
389PhosphorylationGPRGSLDSIGSYRMS
CCCCCCCCCCCEECC		33.8622369663
392PhosphorylationGSLDSIGSYRMSADF
CCCCCCCCEECCCCC		14.1122369663
393PhosphorylationSLDSIGSYRMSADFG
CCCCCCCEECCCCCC		12.7219779198
396PhosphorylationSIGSYRMSADFGRPS
CCCCEECCCCCCCCC		18.7117330950
403PhosphorylationSADFGRPSLDYENLN
CCCCCCCCCCHHHHH		32.2927738172
406PhosphorylationFGRPSLDYENLNQTM
CCCCCCCHHHHHHHH		16.4123749301
414PhosphorylationENLNQTMSQANRYND
HHHHHHHHHHHCCCC		29.5423749301
504PhosphorylationCSKIIKSSRDITRTK
HHHHHHCCCCCCCCE		29.0427017623
583PhosphorylationIMINAGVTPTKKSRI
EEEECCCCCCCCHHH		25.0719823750
585PhosphorylationINAGVTPTKKSRISR
EECCCCCCCCHHHCH		41.5619795423
711PhosphorylationGQIEYIFSDKTGTLT
CCEEEEEECCCCCEE		28.7428889911
726UbiquitinationQNVMEFKKCTINGVS
HHHCCCCCCEECCEE		41.7623749301
770PhosphorylationEIAKDRETMIDELRS
HHHHCHHHHHHHHHC		21.9619779198
777PhosphorylationTMIDELRSMSDNTQF
HHHHHHHCCCCCCCC		34.9521440633
779PhosphorylationIDELRSMSDNTQFCP
HHHHHCCCCCCCCCC		29.0227017623
782PhosphorylationLRSMSDNTQFCPEDL
HHCCCCCCCCCCCCC		28.1928889911
790PhosphorylationQFCPEDLTFVSKEIV
CCCCCCCCCCCHHHH		34.0227017623
793PhosphorylationPEDLTFVSKEIVEDL
CCCCCCCCHHHHHHH		22.0027017623
903PhosphorylationCIIKIPGSTPKDEPK
EEEECCCCCCCCCCC		35.8627017623
904PhosphorylationIIKIPGSTPKDEPKA
EEECCCCCCCCCCCE		40.0327017623
938UbiquitinationNDATLLEKTALHLEE
CCCHHHHHHHHHHHH		38.7822106047
1311PhosphorylationLRKEWNQTKFLWYML
CCCHHCHHHHHHHHH		22.1324961812
1316PhosphorylationNQTKFLWYMLDGVYQ
CHHHHHHHHHHHHHH		7.0224961812
1322PhosphorylationWYMLDGVYQSVICFF
HHHHHHHHHHHHHHH		10.7024961812
1324PhosphorylationMLDGVYQSVICFFFP
HHHHHHHHHHHHHHH		8.8624961812
1332PhosphorylationVICFFFPYLAYHKNM
HHHHHHHHHHHCCCE		9.9824961812
1335PhosphorylationFFFPYLAYHKNMVVT
HHHHHHHHCCCEEEE		15.6724961812
1532PhosphorylationSRKGYRVSTTLERRD
CCCCCEEECCCCCHH		13.4822369663
1533PhosphorylationRKGYRVSTTLERRDQ
CCCCEEECCCCCHHH		32.3222369663
1534PhosphorylationKGYRVSTTLERRDQL
CCCEEECCCCCHHHC		21.0828889911
1542PhosphorylationLERRDQLSPVTTTNN
CCCHHHCCCCCCCCC		16.2222369663
1545PhosphorylationRDQLSPVTTTNNLPR
HHHCCCCCCCCCCCH		31.1422369663
1546PhosphorylationDQLSPVTTTNNLPRR
HHCCCCCCCCCCCHH		27.9722369663
1547PhosphorylationQLSPVTTTNNLPRRS
HCCCCCCCCCCCHHH		16.8522369663
1554PhosphorylationTNNLPRRSMASARGN
CCCCCHHHHHHHHCC		21.7128152593
1557PhosphorylationLPRRSMASARGNKLR
CCHHHHHHHHCCHHH		15.1719779198
1565PhosphorylationARGNKLRTSLDRTRE
HHCCHHHHHHHHHHH		44.0429650682
1566PhosphorylationRGNKLRTSLDRTREE
HCCHHHHHHHHHHHH		23.1024909858
1582PhosphorylationLANHQLDTRYSVERA
HHHCCCCHHHHHHHH		39.8527017623
1585PhosphorylationHQLDTRYSVERARAS
CCCCHHHHHHHHHHH		17.7627017623
1592PhosphorylationSVERARASLDLPGIN
HHHHHHHHCCCCCCC		19.5022369663
1603PhosphorylationPGINHAETLLSQRSR
CCCCHHHHHHHHHHC		33.5121440633
1606PhosphorylationNHAETLLSQRSRDR-
CHHHHHHHHHHCCC-		27.0222369663
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ATC4_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ATC4_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ATC4_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
LEM3_YEASTLEM3physical
17093059
LEM3_YEASTLEM3physical
16600184
MID2_YEASTMID2physical
18467557
LEM3_YEASTLEM3physical
18467557
ATC5_YEASTDNF1physical
18467557
PDR10_YEASTPDR10genetic
19452121
SLA1_YEASTSLA1genetic
20526336
RTG2_YEASTRTG2genetic
20526336
XRN1_YEASTXRN1genetic
20526336
ATC5_YEASTDNF1genetic
22308393
LEM3_YEASTLEM3physical
23060447
ARV1_YEASTARV1genetic
23891562
GPI3_YEASTSPT14genetic
23891562
SRO7_YEASTSRO7genetic
23891562
CG11_YEASTCLN1genetic
25378585
CG13_YEASTCLN3genetic
25378585
BUD31_YEASTBUD31genetic
27708008
YCY0_YEASTYCR090Cgenetic
27708008
BNR1_YEASTBNR1genetic
27708008
SRL3_YEASTSRL3genetic
27708008
QOR_YEASTZTA1genetic
27708008
RDH54_YEASTRDH54genetic
27708008
MSI1_YEASTMSI1genetic
27708008
SWC5_YEASTSWC5genetic
27708008
CHK1_YEASTCHK1genetic
27708008
DPB3_YEASTDPB3genetic
27708008
EXG2_YEASTEXG2genetic
27708008
RAD34_YEASTRAD34genetic
27708008
FLO8_YEASTFLO8genetic
27708008
YFD4_YEASTYFL034Wgenetic
27708008
YFM7_YEASTYFR057Wgenetic
27708008
RRT6_YEASTRRT6genetic
27708008
ATG1_YEASTATG1genetic
27708008
CUL3_YEASTCUL3genetic
27708008
PEX31_YEASTPEX31genetic
27708008
VMA21_YEASTVMA21genetic
27708008
AMA1_YEASTAMA1genetic
27708008
TBP7_YEASTYTA7genetic
27708008
HXT5_YEASTHXT5genetic
27708008
YHT1_YEASTYHR131Cgenetic
27708008
CSK21_YEASTCKA1genetic
27708008
VTH1_YEASTVTH1genetic
27708008
AP3S_YEASTAPS3genetic
27708008
HAL5_YEASTHAL5genetic
27708008
BYE1_YEASTBYE1genetic
27708008
SAC1_YEASTSAC1genetic
27708008
ALY1_YEASTALY1genetic
27708008
PXL1_YEASTPXL1genetic
27708008
RL8B_YEASTRPL8Bgenetic
27708008
YL036_YEASTYLR036Cgenetic
27708008
PAU23_YEASTPAU23genetic
27708008
ARV1_YEASTARV1genetic
27708008
YL352_YEASTYLR352Wgenetic
27708008
U5072_YEASTYML002Wgenetic
27708008
TYW2_YEASTTRM12genetic
27708008
MGR3_YEASTMGR3genetic
27708008
MLF3_YEASTMLF3genetic
27708008
AGA1_YEASTAGA1genetic
27708008
SYC1_YEASTSYC1genetic
27708008
REV1_YEASTREV1genetic
27708008
RL21B_YEASTRPL21Bgenetic
27708008
FRK1_YEASTFRK1genetic
27708008
SPEE_YEASTSPE3genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ATC4_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-386; SER-392; SER-396;SER-403; SER-1532; SER-1542 AND SER-1592, AND MASS SPECTROMETRY.
"Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae.";
Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.;
J. Proteome Res. 6:1190-1197(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-70; SER-389; SER-392 ANDSER-1542, AND MASS SPECTROMETRY.
"Quantitative phosphoproteomics applied to the yeast pheromonesignaling pathway.";
Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J.,Mann M., Jensen O.N.;
Mol. Cell. Proteomics 4:310-327(2005).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1542, AND MASSSPECTROMETRY.

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