| UniProt ID | REV1_YEAST | |
|---|---|---|
| UniProt AC | P12689 | |
| Protein Name | DNA repair protein REV1 | |
| Gene Name | REV1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 985 | |
| Subcellular Localization | Nucleus. Mitochondrion. | |
| Protein Description | Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents. Involved in mitochondrial DNA mutagenesis.. | |
| Protein Sequence | MGEHGGLVDLLDSDLEYSINRETPDKNNCLSQQSVNDSHLTAKTGGLNARSFLSTLSDDSLIEYVNQLSQTNKNNSNPTAGTLRFTTKNISCDELHADLGGGEDSPIARSVIEIQESDSNGDDVKKNTVYTREAYFHEKAHGQTLQDQILKDQYKDQISSQSSKIFKNCVIYINGYTKPGRLQLHEMIVLHGGKFLHYLSSKKTVTHIVASNLPLKKRIEFANYKVVSPDWIVDSVKEARLLPWQNYSLTSKLDEQQKKLDNCKTVNSIPLPSETSLHKGSKCVGSALLPVEQQSPVNLNNLEAKRIVACDDPDFLTSYFAHSRLHHLSAWKANLKDKFLNENIHKYTKITDKDTYIIFHIDFDCFFATVAYLCRSSSFSACDFKRDPIVVCHGTKNSDIASCNYVARSYGIKNGMWVSQAEKMLPNGIKLISLPYTFEQFQLKSEAFYSTLKRLNIFNLILPISIDEAVCVRIIPDNIHNTNTLNARLCEEIRQEIFQGTNGCTVSIGCSDSLVLARLALKMAKPNGYNITFKSNLSEEFWSSFKLDDLPGVGHSTLSRLESTFDSPHSLNDLRKRYTLDALKASVGSKLGMKIHLALQGQDDEESLKILYDPKEVLQRKSLSIDINWGIRFKNITQVDLFIERGCQYLLEKLNEINKTTSQITLKLMRRCKDAPIEPPKYMGMGRCDSFSRSSRLGIPTNEFGIIATEMKSLYRTLGCPPMELRGLALQFNKLVDVGPDNNQLKLRLPFKTIVTNRAFEALPEDVKNDINNEFEKRNYKRKESGLTSNSLSSKKKGFAISRLEVNDLPSTMEEQFMNELPTQIRAEVRHDLRIQKKIQQTKLGNLQEKIKRREESLQNEKNHFMGQNSIFQPIKFQNLTRFKKICQLVKQWVAETLGDGGPHEKDVKLFVKYLIKLCDSNRVHLVLHLSNLISRELNLCAFLNQDHSGFQTWERILLNDIIPLLNRNKHTYQTVRKLDMDFEV | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 17 | Phosphorylation | LLDSDLEYSINRETP HCCCCCCHHCCCCCC | 23.34 | 28132839 | |
| 31 | Phosphorylation | PDKNNCLSQQSVNDS CCCCCCCCCCCCCHH | 28.51 | 28889911 | |
| 91 | Phosphorylation | RFTTKNISCDELHAD EEEECCEECCEEEEC | 25.55 | 23749301 | |
| 105 | Phosphorylation | DLGGGEDSPIARSVI CCCCCCCCHHHCCEE | 17.57 | 23749301 | |
| 224 | Phosphorylation | KRIEFANYKVVSPDW HCEEECCCEEECCHH | 11.17 | 19823750 | |
| 228 | Phosphorylation | FANYKVVSPDWIVDS ECCCEEECCHHHHHC | 21.82 | 19823750 | |
| 235 | Phosphorylation | SPDWIVDSVKEARLL CCHHHHHCHHHHHCC | 24.97 | 19823750 | |
| 268 | Phosphorylation | DNCKTVNSIPLPSET HCCCCCCCCCCCCCC | 22.65 | 28889911 | |
| 273 | Phosphorylation | VNSIPLPSETSLHKG CCCCCCCCCCCCCCC | 62.28 | 28889911 | |
| 275 | Phosphorylation | SIPLPSETSLHKGSK CCCCCCCCCCCCCCC | 40.71 | 28889911 | |
| 276 | Phosphorylation | IPLPSETSLHKGSKC CCCCCCCCCCCCCCC | 25.15 | 28889911 | |
| 281 | Phosphorylation | ETSLHKGSKCVGSAL CCCCCCCCCCCCCCE | 27.90 | 28889911 | |
| 295 | Phosphorylation | LLPVEQQSPVNLNNL EECHHHCCCCCCCCC | 30.43 | 23749301 | |
| 692 | Phosphorylation | MGRCDSFSRSSRLGI CCCCCCCCCHHCCCC | 34.89 | 28889911 | |
| 694 | Phosphorylation | RCDSFSRSSRLGIPT CCCCCCCHHCCCCCC | 20.72 | 19779198 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of REV1_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of REV1_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of REV1_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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