| UniProt ID | AVL9_YEAST | |
|---|---|---|
| UniProt AC | Q12500 | |
| Protein Name | Late secretory pathway protein AVL9 | |
| Gene Name | AVL9 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 764 | |
| Subcellular Localization | Cytoplasm . | |
| Protein Description | Functions in the late secretory pathway. Required for the generation of secretory vesicles as well as for actin polarization and polarized growth.. | |
| Protein Sequence | MDEHEEAVIFGICLVDFHHKRGPEIEYWYGLPEGTQSAELWPNLPFQALPDGSHSFEETFTYFTLLYDERRQRSPPNGATDLSDDSINDNTTLFAISCSRQIKSDELVTKDKDVTRSTVQKAIVVISRQPIFGQIKDKLSIVTNAFFLQHDFGDRKIIQSLYENLKSIYTPASLVRNAENRLYIGLCLRKILHDFKRNALVLLKAIMLEKKIIVYGNDVEALCNLQFGLISLIPDLMSNLQDSGSPQLFQDISKLNVVDSFKSSNRESVLRFLGFPLPIFEKGGLFSPYTPLQQMNDIRSERTLFFMIGSSNTLLAEQKEELCHIFVNTDNSTVDILDKTLNPVLQLSSHDKKWIESISGIVSDTWNENDDETPKNSQFEGSEDFIRWQFEDYLTGLLSSVKLSDYLDLHKENDQALKTIPEDMLNSNPVHLFNLNWVQSWKETQNFLIFNSRTDDRLFDLFPPKHIYNGADTLSLLQQRFLATFHNLKRSSSNSSSNKNGHQSEEDIKDQESIESKKSVSQISVNPGKNTDKPAANLWNSWKEYFNKPKNTANEDVTESTEDLKNRSKTSNAIQKAMMGLGLHYKPDAETDQQSEEVGNSEDNEDDDTDEDSEDDDDDGGDDDDSEDDDDDDDGEGDENGDDGEGDENGDDGEGDENGDKEDSQDFSNGFTDVTNINTDHDKENEQNFEGNAENFNEDETVADKDIEGGPESNKNSDSKTDIYENDRNVEDSSKTRNTVKKSNEEGGANDAAIGNCVQDEEKL | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 109 | Phosphorylation | IKSDELVTKDKDVTR CCCCCCCCCCCCCCH | 46.26 | 30377154 | |
| 260 | Phosphorylation | SKLNVVDSFKSSNRE HHCCCHHHCCCCCHH | 23.98 | 30377154 | |
| 268 | Phosphorylation | FKSSNRESVLRFLGF CCCCCHHHHHHHHCC | 24.18 | 21440633 | |
| 352 | Acetylation | LQLSSHDKKWIESIS HHCCCCCHHHHHHHH | 44.58 | 24489116 | |
| 452 | Phosphorylation | QNFLIFNSRTDDRLF CCEEEEECCCCCCCH | 26.30 | 29650682 | |
| 493 | Phosphorylation | HNLKRSSSNSSSNKN HHHHCCCCCCCCCCC | 41.81 | 28889911 | |
| 504 | Phosphorylation | SNKNGHQSEEDIKDQ CCCCCCCCHHHHCCH | 36.96 | 22369663 | |
| 513 | Phosphorylation | EDIKDQESIESKKSV HHHCCHHHHHHCCCC | 26.48 | 22369663 | |
| 516 | Phosphorylation | KDQESIESKKSVSQI CCHHHHHHCCCCCCE | 43.65 | 22369663 | |
| 519 | Phosphorylation | ESIESKKSVSQISVN HHHHHCCCCCCEECC | 30.64 | 22369663 | |
| 521 | Phosphorylation | IESKKSVSQISVNPG HHHCCCCCCEECCCC | 28.96 | 22369663 | |
| 524 | Phosphorylation | KKSVSQISVNPGKNT CCCCCCEECCCCCCC | 14.27 | 22369663 | |
| 533 | Ubiquitination | NPGKNTDKPAANLWN CCCCCCCCHHHHHHH | 34.22 | 24961812 | |
| 552 | Phosphorylation | YFNKPKNTANEDVTE HHCCCCCCCCCCCHH | 36.67 | 21126336 | |
| 558 | Phosphorylation | NTANEDVTESTEDLK CCCCCCCHHCHHHHH | 36.22 | 22369663 | |
| 560 | Phosphorylation | ANEDVTESTEDLKNR CCCCCHHCHHHHHHH | 27.94 | 22369663 | |
| 561 | Phosphorylation | NEDVTESTEDLKNRS CCCCHHCHHHHHHHH | 27.56 | 22369663 | |
| 565 | Ubiquitination | TESTEDLKNRSKTSN HHCHHHHHHHHHHHH | 63.74 | 24961812 | |
| 565 | Acetylation | TESTEDLKNRSKTSN HHCHHHHHHHHHHHH | 63.74 | 24489116 | |
| 568 | Phosphorylation | TEDLKNRSKTSNAIQ HHHHHHHHHHHHHHH | 50.07 | 19779198 | |
| 571 | Phosphorylation | LKNRSKTSNAIQKAM HHHHHHHHHHHHHHH | 28.18 | 19779198 | |
| 664 | Phosphorylation | ENGDKEDSQDFSNGF CCCCHHHCHHCCCCC | 32.51 | 29136822 | |
| 668 | Phosphorylation | KEDSQDFSNGFTDVT HHHCHHCCCCCCCCE | 44.31 | 30377154 | |
| 672 | Phosphorylation | QDFSNGFTDVTNINT HHCCCCCCCCEECCC | 30.84 | 29136822 | |
| 679 | Phosphorylation | TDVTNINTDHDKENE CCCEECCCCCCHHCC | 30.80 | 28889911 | |
| 701 | Phosphorylation | ENFNEDETVADKDIE CCCCCCCCCCCCCCC | 33.06 | 24909858 | |
| 713 | Phosphorylation | DIEGGPESNKNSDSK CCCCCCCCCCCCCCC | 57.12 | 27717283 | |
| 717 | Phosphorylation | GPESNKNSDSKTDIY CCCCCCCCCCCCCCH | 44.89 | 21440633 | |
| 719 | Phosphorylation | ESNKNSDSKTDIYEN CCCCCCCCCCCCHHC | 36.96 | 28889911 | |
| 720 | Ubiquitination | SNKNSDSKTDIYEND CCCCCCCCCCCHHCC | 56.03 | 24961812 | |
| 721 | Phosphorylation | NKNSDSKTDIYENDR CCCCCCCCCCHHCCC | 31.42 | 24961812 | |
| 733 | Phosphorylation | NDRNVEDSSKTRNTV CCCCCCCCHHHHCHH | 21.89 | 29136822 | |
| 734 | Phosphorylation | DRNVEDSSKTRNTVK CCCCCCCHHHHCHHH | 50.82 | 29136822 | |
| 735 | Ubiquitination | RNVEDSSKTRNTVKK CCCCCCHHHHCHHHH | 56.29 | 24961812 | |
| 736 | Phosphorylation | NVEDSSKTRNTVKKS CCCCCHHHHCHHHHC | 30.97 | 29136822 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of AVL9_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of AVL9_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of AVL9_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-519; SER-521; SER-524;SER-560 AND THR-561, AND MASS SPECTROMETRY. | |
| "Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases."; Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.; Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-560, AND MASSSPECTROMETRY. | |
