SRO77_YEAST - dbPTM
SRO77_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SRO77_YEAST
UniProt AC P38163
Protein Name Lethal(2) giant larvae protein homolog SRO77
Gene Name SRO77
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 1010
Subcellular Localization
Protein Description Acts as an allosteric regulator of polarized exocytosis by promoting the targeted fusion of vesicles with the plasma membrane. Involved in maintenance of ion homeostasis in cells exposed to NaCl stress. May be involved in the targeting of the myosin proteins to their intrinsic pathways. Multicopy suppressor of RHO3. May also participate in the maintenance of cell polarity and bud growth..
Protein Sequence MFKKSRHLKNVSNAIKSARVHDVSNGINSKFFDTKKICTYGINGRITVTTFDYTQSLLAVATTAGEIHVYGQKQIEVVFTLKNRPQIKHMRFIKGIYLIAVDEKSNIIVLSVHSKQILTTVFCPNSITCIETDPSLDWMLIGLESGSILIYDVDRNQMSKLKIENFQKSVFLPKERLSPVISIQWNPRDIGTILISYEHITVIYSFIDYKVKQHFFYQLEPYAPGGDLSTNIEKKRTPKVIQSLYHPNSLHILTVHEDNSLVFWDVNSGKLIHARSIFETHVNFPNPALKDCSFTETPAIFKVSWLCQRNPEYTSLLIATKATENPCLPQEITMIDLGGTPMYSVTSFDAMSKYYAKPVQQKLFSLIGKAPLINFLPLPKASPYFGGCHDTNLILLLLEDGELETLIYPAGSFSSKASIFPRSLAWVRPTVTTCIAQSVQKNLWLGMMTIAQSESFLKGGIPATRNIRRHETRSALLTGHSNGSVRIWDASHSEVTDNAVFEVNTAKVLNRATNLAIKNISFASETLELAVSSEVGDVILFKFETNKFYGQLPKSDALQLKFSRFSLDDSKTILVDVSDRGPTNVKQGFIPSTVIHAKKGAVSAIMNSNIGFVAVGFIEGTLIILDRRGPAIIFNENIRVISKAGSSYVSTVHFCVMEYGDDGFSSILMLCGTDIGELMTFKILPATNGRFEVKFTDATKTNNQGKILGINSFAKDTGYSCSATISKMQGLSKGIAIPGFVTISGANDIRLVSPGKSKDTHALFKYPIATSGLSFIPIIDGKGERKLSTIMIVLLINGDIKVLTVPELKEVKNLRCPVPLSAQYVENSSILENGDIVIRTGKFQASLISVLNESATGTNHTADISQHTPIDTLYNPDLKIGYRPQVNSLQWARGTIYCTPYQLDELLGGIERPESKYEESAIARGCISSSSSNAARKLPPGTEDHRYARPVRSSGRSNGYGVLKSVSRAIETRLDTVETTINDYATTMGQTMNDAMEETGRDMMKSAVGF
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
114PhosphorylationIIVLSVHSKQILTTV
EEEEEECCCEEEEEE		24.8919779198
513PhosphorylationAKVLNRATNLAIKNI
HHHHHHHHHHEECCC		27.7727214570
744PhosphorylationIPGFVTISGANDIRL
CCCEEEEECCCCEEE		23.6128889911
979PhosphorylationTRLDTVETTINDYAT
HHHHHCHHHHHHHHH		28.7419779198
986PhosphorylationTTINDYATTMGQTMN
HHHHHHHHHHCHHHH		15.8719779198
991PhosphorylationYATTMGQTMNDAMEE
HHHHHCHHHHHHHHH		16.5319779198
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SRO77_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SRO77_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SRO77_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
ATG17_YEASTATG17physical
11489916
KAPR_YEASTBCY1physical
11489916
ENT2_YEASTENT2physical
11489916
NIP80_YEASTNIP100physical
11489916
AP18A_YEASTYAP1801physical
11489916
YIP1_YEASTYIP1physical
11489916
APP1_YEASTAPP1physical
11489916
MCA1_YEASTMCA1physical
11489916
KIN3_YEASTKIN3physical
11489916
MYO1_YEASTMYO1genetic
9691031
KRE9_YEASTKRE9genetic
23891562
COPB_YEASTSEC26genetic
23891562
SRO7_YEASTSRO7genetic
23891562
MSMO_YEASTERG25genetic
23891562
ALG1_YEASTALG1genetic
23891562
SEC5_YEASTSEC5genetic
23891562
GPI13_YEASTGPI13genetic
23891562
ECM9_YEASTECM9genetic
23891562
SEC10_YEASTSEC10genetic
23891562
RHO1_YEASTRHO1genetic
25061043
ROM2_YEASTROM2genetic
25061043
TUS1_YEASTTUS1genetic
25061043
TOR1_YEASTTOR1genetic
25061043
OST2_YEASTOST2genetic
27708008
CALM_YEASTCMD1genetic
27708008
MCM7_YEASTMCM7genetic
27708008
NSE4_YEASTNSE4genetic
27708008
SEC7_YEASTSEC7genetic
27708008
ERF3_YEASTSUP35genetic
27708008
CDC1_YEASTCDC1genetic
27708008
SYF1_YEASTSYF1genetic
27708008
SMT3_YEASTSMT3genetic
27708008
RSP5_YEASTRSP5genetic
27708008
CCA1_YEASTCCA1genetic
27708008
STT3_YEASTSTT3genetic
27708008
PRS8_YEASTRPT6genetic
27708008
SWC4_YEASTSWC4genetic
27708008
BRL1_YEASTBRL1genetic
27708008
CDC11_YEASTCDC11genetic
27708008
NSE1_YEASTNSE1genetic
27708008
NEP1_YEASTEMG1genetic
27708008
SC61A_YEASTSEC61genetic
27708008
AFG2_YEASTAFG2genetic
27708008
ERO1_YEASTERO1genetic
27708008
MCM1_YEASTMCM1genetic
27708008
NOP2_YEASTNOP2genetic
27708008
SEC12_YEASTSEC12genetic
27708008
NAB3_YEASTNAB3genetic
27708008
HRR25_YEASTHRR25genetic
27708008
MED10_YEASTNUT2genetic
27708008
SRO7_YEASTSRO7genetic
27453043
G3P3_YEASTTDH3genetic
27453043
TOP1_YEASTTOP1genetic
27453043
IME1_YEASTIME1genetic
27453043
AGP3_YEASTAGP3genetic
27453043
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SRO77_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-744, AND MASSSPECTROMETRY.

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