NCB5R_YEAST - dbPTM
NCB5R_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID NCB5R_YEAST
UniProt AC P38626
Protein Name NADH-cytochrome b5 reductase 1
Gene Name CBR1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 284
Subcellular Localization Endoplasmic reticulum membrane
Single-pass membrane protein. Mitochondrion outer membrane
Single-pass membrane protein .
Protein Description Electron donor reductase for cytochrome b5. The cytochrome b5/NADH cytochrome b5 reductase electron transfer system supports the catalytic activity of several sterol biosynthetic enzymes. Plays a role in bud morphology..
Protein Sequence MAIDAQKLVVVIVIVVVPLLFKFIIGPKTKPVLDPKRNDFQSFPLVEKTILTHNTSMYKFGLPHADDVLGLPIGQHIVIKANINGKDITRSYTPTSLDGDTKGNFELLVKSYPTGNVSKMIGELKIGDSIQIKGPRGNYHYERNCRSHLGMIAGGTGIAPMYQIMKAIAMDPHDTTKVSLVFGNVHEEDILLKKELEALVAMKPSQFKIVYYLDSPDREDWTGGVGYITKDVIKEHLPAATMDNVQILICGPPAMVASVRRSTVDLGFRRSKPLSKMEDQVFVF
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
36UbiquitinationTKPVLDPKRNDFQSF
CCCCCCCCCCCCCCC		64.6017644757
42PhosphorylationPKRNDFQSFPLVEKT
CCCCCCCCCCEEEEE		28.9127017623
48AcetylationQSFPLVEKTILTHNT
CCCCEEEEEEECCCC		33.1324489116
48UbiquitinationQSFPLVEKTILTHNT
CCCCEEEEEEECCCC		33.1317644757
59AcetylationTHNTSMYKFGLPHAD
CCCCHHHHCCCCCHH		25.0624489116
59UbiquitinationTHNTSMYKFGLPHAD
CCCCHHHHCCCCCHH		25.0617644757
80UbiquitinationIGQHIVIKANINGKD
CCCEEEEEEEECCCC		25.2017644757
86UbiquitinationIKANINGKDITRSYT
EEEEECCCCCCCEEC		41.2823749301
95PhosphorylationITRSYTPTSLDGDTK
CCCEECCCCCCCCCC		33.8421440633
102UbiquitinationTSLDGDTKGNFELLV
CCCCCCCCCCEEEEE		57.5115699485
110AcetylationGNFELLVKSYPTGNV
CCEEEEEEECCCCCH		44.2124489116
133AcetylationIGDSIQIKGPRGNYH
ECCEEEEECCCCCCC		46.6224489116
162PhosphorylationGTGIAPMYQIMKAIA
CCCCHHHHHHHHHHH		8.2028889911
177UbiquitinationMDPHDTTKVSLVFGN
CCCCCCCEEEEEECC		31.7317644757
193UbiquitinationHEEDILLKKELEALV
CHHHHHHHHHHHHHH		40.5317644757
193AcetylationHEEDILLKKELEALV
CHHHHHHHHHHHHHH		40.5324489116
194UbiquitinationEEDILLKKELEALVA
HHHHHHHHHHHHHHH		68.4517644757
203UbiquitinationLEALVAMKPSQFKIV
HHHHHHCCHHHCEEE		31.6017644757
208UbiquitinationAMKPSQFKIVYYLDS
HCCHHHCEEEEEECC		24.5117644757
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of NCB5R_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of NCB5R_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of NCB5R_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
YA11A_YEASTYAR010Cphysical
16554755
YP12A_YEASTYAR010Cphysical
16554755
H2A2_YEASTHTA2physical
16554755
RS9B_YEASTRPS9Bphysical
16554755
FBRL_YEASTNOP1physical
16554755
YRA1_YEASTYRA1physical
16554755
PUF4_YEASTPUF4physical
16554755
FKS2_YEASTGSC2physical
16554755
RL43A_YEASTRPL43Bphysical
16554755
RL43B_YEASTRPL43Bphysical
16554755
RL10_YEASTRPL10physical
16554755
STM1_YEASTSTM1physical
16554755
FKS1_YEASTFKS1physical
16554755
IMDH3_YEASTIMD3physical
16554755
TCB3_YEASTTCB3physical
16554755
VDAC1_YEASTPOR1physical
16554755
TOP1_YEASTTOP1physical
16554755
RL36B_YEASTRPL36Bphysical
16554755
GET2_YEASTGET2genetic
16269340
COPE_YEASTSEC28genetic
16269340
MTC4_YEASTMTC4genetic
16269340
YM122_YEASTYMR122W-Agenetic
16269340
PRY1_YEASTPRY1genetic
16269340
CAB5_YEASTCAB5genetic
16269340
GAS1_YEASTGAS1genetic
16269340
YMD8_YEASTYMD8genetic
16269340
TLG2_YEASTTLG2genetic
16269340
CHO2_YEASTCHO2genetic
16269340
GUP1_YEASTGUP1genetic
16269340
PLMT_YEASTOPI3genetic
16269340
AP3M_YEASTAPM3genetic
16269340
TMEDA_YEASTERV25physical
18467557
ORM2_YEASTORM2physical
18467557
HSP71_YEASTSSA1physical
19536198
SSB1_YEASTSSB1physical
19536198
RL4A_YEASTRPL4Agenetic
27708008
VHC1_YEASTVHC1genetic
27708008
YPT10_YEASTYPT10genetic
27708008
TXTP_YEASTCTP1genetic
27708008
GFD2_YEASTGFD2genetic
27708008
TMA17_YEASTTMA17genetic
27708008
SNQ2_YEASTSNQ2genetic
27708008
PMP3_YEASTPMP3genetic
27708008
MTC1_YEASTMTC1genetic
27708008
LST4_YEASTLST4genetic
27708008
TRK2_YEASTTRK2genetic
27708008
SRL3_YEASTSRL3genetic
27708008
POC1_YEASTPBA1genetic
27708008
VRP1_YEASTVRP1genetic
27708008
MKS1_YEASTMKS1genetic
27708008
RAS2_YEASTRAS2genetic
27708008
RTG1_YEASTRTG1genetic
27708008
IRA2_YEASTIRA2genetic
27708008
FYV12_YEASTFYV12genetic
27708008
AIM44_YEASTAIM44genetic
27708008
YP022_YEASTYPR022Cgenetic
27708008
MDM36_YEASTMDM36genetic
27708008
MRC1_YEASTMRC1genetic
27694803
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of NCB5R_YEAST

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Related Literatures of Post-Translational Modification

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