TMA17_YEAST - dbPTM
TMA17_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID TMA17_YEAST
UniProt AC Q12513
Protein Name Translation machinery-associated protein 17
Gene Name TMA17
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 150
Subcellular Localization Cytoplasm . Nucleus .
Protein Description ATPase-dedicated chaperone that assists the formation of the RPT6-RPT3 ATPase pair, an early step in proteasome assembly. Plays a key role in maintaining homeostatic proteasome levels and adjusting proteasome assembly when demands increase, such as during proteasome stresses. Function overlaps with RPN14..
Protein Sequence MCSAGGIRRPIQIEEFKTAISGMSDMELAQIKTEIENSINHLQRSNARLGKYIAKLEGADDRLEADDSDDLENIDSGDLALYKDSVRENEIVLNNYNERVDALEQETVYRKTGHGKSKHEVEAKDNTNKGPDVDMDNSNVDVVTPNSIFI
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
3Phosphorylation-----MCSAGGIRRP
-----CCCCCCCCCC		28.7530377154
24PhosphorylationKTAISGMSDMELAQI
HHHHCCCCHHHHHHH		37.0128889911
33PhosphorylationMELAQIKTEIENSIN
HHHHHHHHHHHHHHH		43.7728889911
38PhosphorylationIKTEIENSINHLQRS
HHHHHHHHHHHHHHH		16.3928889911
45PhosphorylationSINHLQRSNARLGKY
HHHHHHHHHHHHHHH		23.1428889911
51AcetylationRSNARLGKYIAKLEG
HHHHHHHHHHHHHCC		37.7725381059
52PhosphorylationSNARLGKYIAKLEGA
HHHHHHHHHHHHCCC		12.3328889911
68PhosphorylationDRLEADDSDDLENID
CCCCCCCCCCHHCCC		33.3022369663
76PhosphorylationDDLENIDSGDLALYK
CCHHCCCCCCEEEEE		30.3422369663
82PhosphorylationDSGDLALYKDSVREN
CCCCEEEEECCCCCC		13.7222369663
85PhosphorylationDLALYKDSVRENEIV
CEEEEECCCCCCEEE		20.9429136822
127PhosphorylationEVEAKDNTNKGPDVD
EEECCCCCCCCCCCC		48.7328889911
144PhosphorylationNSNVDVVTPNSIFI-
CCCCCEECCCCCCC-		19.3219779198
147PhosphorylationVDVVTPNSIFI----
CCEECCCCCCC----		21.7819779198
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of TMA17_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of TMA17_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of TMA17_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
PUT3_YEASTPUT3physical
10688190
BUD21_YEASTBUD21physical
10688190
SEC66_YEASTSEC66genetic
20093466
STE50_YEASTSTE50genetic
20093466
SNT1_YEASTSNT1genetic
20093466
TPS2_YEASTTPS2genetic
20093466
AGP3_YEASTAGP3genetic
20093466
MNT2_YEASTMNT2genetic
20093466
YGB5_YEASTYGL015Cgenetic
20093466
MTL1_YEASTMTL1genetic
20093466
EIF2A_YEASTYGR054Wgenetic
20093466
PEX8_YEASTPEX8genetic
20093466
NNF2_YEASTNNF2genetic
20093466
CLD1_YEASTCLD1genetic
20093466
NEM1_YEASTNEM1genetic
20093466
FMC1_YEASTFMC1genetic
20093466
YIC9_YEASTYIL029Cgenetic
20093466
INA22_YEASTINA22genetic
20093466
YJV8_YEASTYJL218Wgenetic
20093466
ALY2_YEASTALY2genetic
20093466
SDHX_YEASTYJL045Wgenetic
20093466
POC2_YEASTADD66genetic
20093466
MYO3_YEASTMYO3genetic
20093466
KTI12_YEASTKTI12genetic
20093466
MEH1_YEASTMEH1genetic
20093466
RL8B_YEASTRPL8Bgenetic
20093466
MMM1_YEASTMMM1genetic
20093466
ART10_YEASTART10genetic
20093466
MSC1_YEASTMSC1genetic
20093466
USA1_YEASTUSA1genetic
20093466
TMEDA_YEASTERV25genetic
20093466
BCH1_YEASTBCH1genetic
20093466
AF9_YEASTYAF9genetic
20093466
NST1_YEASTNST1genetic
20093466
COX5A_YEASTCOX5Agenetic
20093466
PHO80_YEASTPHO80genetic
20093466
ATG5_YEASTATG5genetic
20093466
SPEE_YEASTSPE3genetic
20093466
HDA3_YEASTHDA3genetic
20093466
YIC9_YEASTYIL029Cgenetic
27708008
ATG5_YEASTATG5genetic
27708008
PRS8_YEASTRPT6genetic
27708008
GPI10_YEASTGPI10genetic
27708008
PSB5_YEASTPRE2genetic
27708008
DHE5_YEASTGDH3genetic
27708008
RV161_YEASTRVS161genetic
27708008
SNT1_YEASTSNT1genetic
27708008
IMG2_YEASTIMG2genetic
27708008
SWF1_YEASTSWF1genetic
27708008
PMP3_YEASTPMP3genetic
27708008
BCS1_YEASTBCS1genetic
27708008
RS17B_YEASTRPS17Bgenetic
27708008
SDC1_YEASTSDC1genetic
27708008
AGP3_YEASTAGP3genetic
27708008
YGB5_YEASTYGL015Cgenetic
27708008
VAM7_YEASTVAM7genetic
27708008
MTL1_YEASTMTL1genetic
27708008
EIF2A_YEASTYGR054Wgenetic
27708008
PEX8_YEASTPEX8genetic
27708008
CLD1_YEASTCLD1genetic
27708008
NEM1_YEASTNEM1genetic
27708008
MSC7_YEASTMSC7genetic
27708008
DOT5_YEASTDOT5genetic
27708008
FMC1_YEASTFMC1genetic
27708008
VTH1_YEASTVTH1genetic
27708008
INA22_YEASTINA22genetic
27708008
SDHX_YEASTYJL045Wgenetic
27708008
YJV8_YEASTYJL218Wgenetic
27708008
DHOM_YEASTHOM6genetic
27708008
MYO3_YEASTMYO3genetic
27708008
POC2_YEASTADD66genetic
27708008
MEH1_YEASTMEH1genetic
27708008
MSA2_YEASTMSA2genetic
27708008
MMM1_YEASTMMM1genetic
27708008
RL8B_YEASTRPL8Bgenetic
27708008
BRE2_YEASTBRE2genetic
27708008
COA4_YEASTCOA4genetic
27708008
BUD8_YEASTBUD8genetic
27708008
ART10_YEASTART10genetic
27708008
MSC1_YEASTMSC1genetic
27708008
COX5A_YEASTCOX5Agenetic
27708008
VHS3_YEASTVHS3genetic
27708008
SPEE_YEASTSPE3genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of TMA17_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-24 AND SER-68, AND MASSSPECTROMETRY.
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-68, AND MASSSPECTROMETRY.
"Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae.";
Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.;
J. Proteome Res. 6:1190-1197(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-68, AND MASSSPECTROMETRY.

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